Risk of developing asthma in young children with atopic eczema: A systematic review

Hulst, Annelies E. van der; Klip, Helen; Brand, Paul

doi:10.1016/j.jaci.2007.05.042

Cited by 255 publications

(171 citation statements)

References 29 publications

Supporting

Mentioning

150

Contrasting

Unclassified

Order By: Relevance

“…The prevalence of asthma by age 7 years (32.8%) in subjects with childhood eczema in our study was almost identical to that described in the systematic review by van der Hulst et al, 18 supporting their view that the majority of children with eczema will not develop childhood asthma. Flexural involvement is considered a marker of atopy, 32 in turn a predictor of childhood asthma.…”

Section: Discussionsupporting

confidence: 90%

“…The results suggest that the effect of childhood eczema on asthma risk continues well past childhood, extending what is already known about this subject. Although the majority of children with eczema will not develop childhood asthma, 18 our results suggest that childhood eczema may progress to incident asthma in preadolescence, adolescence, and adult life. Lifetime asthma risk from childhood eczema may be greater than previously realized.…”

Section: Discussionmentioning

confidence: 63%

“…[15][16][17] A recent systematic review indicated that about 1/3 of children with atopic eczema before age 4 years will develop asthma by age 6 years or older. 18 The eczema/asthma association has been explained by invoking the atopic march [19][20][21] whereby children with eczema have a high risk of progression to asthma and/or allergic rhinitis later in childhood. Epicutaneous sensitization of the bronchusassociated lymphoid tissue has been proposed as a causal pathway.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Childhood eczema and asthma incidence and persistence: A cohort study from childhood to middle age

Burgess¹,

Dharmage²,

Byrnes³

et al. 2008

Journal of Allergy and Clinical Immunology

102

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 63%

mentioning

confidence: 99%

See 1 more Smart Citation

Childhood eczema and asthma incidence and persistence: A cohort study from childhood to middle age

Burgess¹,

Dharmage²,

Byrnes³

et al. 2008

Journal of Allergy and Clinical Immunology

102

View full text Add to dashboard Cite

“…[2][3][4][5][6][7] Epicutaneous sensitisation to aeroallergens has been thought to be responsible, with subsequent migration of sensitised T cells into the nose and airways, causing upper and lower airway disease. [8,9] Aeroallergen sensitisation is common in AD patients, and in the EPAAC (Early Prevention of Asthma and Allergies in Children) study, 20 -40% of AD patients were sensitised to house-dust mite.…”

Section: Researchmentioning

confidence: 99%

Respiratory comorbidity in South African children with atopic dermatitis

2017

View full text Add to dashboard Cite

This article explores the comorbidity between AD, food allergy, aeroallergen sensitisation, asthma and allergic rhinitis in South African (SA) children. Age-dependent patterns of aeroallergen sensitisation are explored, and indoor v. outdoor aeroallergens are differentiated with regard to risk profiles for comorbid conditions. Background. Atopic dermatitis (AD) is an early and important step in the propagation of the allergic march, enhancing food and respiratory allergies via epicutaneous sensitisation to allergens. Objectives. To determine the prevalence and patterns of aeroallergen sensitisation, asthma and allergic rhinitis in South African (SA) children with AD.Methods. This was a prospective, observational study in a paediatric university hospital in Cape Town, SA. Children with moderate to severe AD, aged 6 months -10 years, were recruited randomly and investigated for food sensitisation and allergy. They were assessed for sensitisation to aeroallergens by the immuno solid-phase allergen chip test. House-dust mite DerP and DerF, dust mite Eur m, Timothy grass, Bermuda grass, tree pollen, mould (Alternaria), cat and dog sensitisation patterns were analysed. Symptoms of asthma and allergic rhinitis were elicited using a questionnaire modified from the International Study of Asthma and Allergies in Childhood study questions. Results. One hundred participants (59 black Africans and 41 of mixed ethnicity) were enrolled (median age 42 months). Of the participants, 39% had symptoms of asthma and 53% symptoms of allergic rhinitis; 89% tested positive to at least one aeroallergen, most commonly house-dust mite DerP or DerF (81%), dust mite Eur m (51%), Timothy grass (36%) and cat (35%). Asthma, allergic rhinitis and aeroallergen sensitisation all increased with increasing age, while food allergy decreased with age. Food allergy was not an independent risk factor for respiratory allergies. Children were sensitised to indoor allergens (house-dust mite, pets) from an early age, while pollen allergies increased with age. Conclusions. In this cohort of SA children with moderate to severe AD, comorbidity with respiratory allergies was high. The prevalence of respiratory allergies increased with age while food allergy decreased with age, in keeping with the pattern of the allergic march. Seasonal allergies increased with age, while house-dust mite and pet allergy peaked in younger children, in keeping with early exposure via a defective skin barrier. Early and effective restoration of the skin barrier in AD may be a target for reducing aeroallergen-related diseases.

show abstract

“…[3][4][5][6][7] A key function of the cohesin complex is to facilitate proper segregation of chromosomes by maintaining them in proximity from the point of sister chromatid synthesis until they are segregated at mitosis. 8 However, additional functions of cohesin relevant to immune functions have been increasingly described.…”

Section: Cdls-cornelia De Lange Syndrome Cvid-common Variable Immunodmentioning

confidence: 99%

Immunologic Features of Cornelia de Lange Syndrome

2013

PEDIATRICS

View full text Add to dashboard Cite

Risk of developing asthma in young children with atopic eczema: A systematic review

Cited by 255 publications

References 29 publications

Childhood eczema and asthma incidence and persistence: A cohort study from childhood to middle age

Childhood eczema and asthma incidence and persistence: A cohort study from childhood to middle age

Respiratory comorbidity in South African children with atopic dermatitis

Immunologic Features of Cornelia de Lange Syndrome

Contact Info

Product

Resources

About