Risk of Developing Depressive Disorders following Rheumatoid Arthritis: A Nationwide Population-Based Study

Wang, Shu Li; Chang, Cheng-Ho; Hu, Li; Tsai, Shih‐Jen; Yang, Albert C.; You, Zi Hong

doi:10.1371/journal.pone.0107791

Cited by 34 publications

(36 citation statements)

References 54 publications

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“…A study that used the same database with a longer follow-up period (10 years) reported that individuals with RA were 2.06 times as likely to develop depressive disorders (95% CI: 1.73–2.44, p < 0.001) as those without RA, after adjusting for age, sex, and comorbidities. Further, among individuals with RA, most depressive disorders developed within five years after RA diagnosis [151]. When examining a cohort of 1,609 individuals with no prior history of depression and SLE, it was found that incidence of depression was as high as 29.7 episodes per 1000 person-years [152].…”

Section: Incident Depression and Arthritismentioning

confidence: 99%

Healthcare burden of depression in adults with arthritis

Sambamoorthi

Shah

Zhao

2017

Expert Review of Pharmacoeconomics & Outcomes Research

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Introduction Arthritis and depression are two of the top disabling conditions. When arthritis and depression exist in the same individual, they can interact with each other negatively and pose a significant healthcare burden on the patients, their families, payers, healthcare systems, and society as a whole. Areas covered The primary objective of this review is to summarize, identify knowledge gaps and discuss the challenges in estimating the healthcare burden of depression among individuals with arthritis. Electronic literature searches were performed on PubMed, Embase, EBSCOhost, Scopus, the Cochrane Library, and Google Scholar to identify relevant studies. Expert Commentary Our review revealed that the prevalence of depression varied depending on the definition of depression, type of arthritis, tools and threshold points used to identify depression, and the country of residence. Depression exacerbated arthritis-related complications as well as pain and was associated with poor health-related quality of life, disability, mortality, and high financial burden. There were significant knowledge gaps in estimates of incident depression rates, depression attributable disability, and healthcare utilization, direct and indirect healthcare costs among individuals with arthritis.

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Section: Incident Depression and Arthritismentioning

confidence: 99%

Healthcare burden of depression in adults with arthritis

Sambamoorthi

Shah

Zhao

2017

Expert Review of Pharmacoeconomics & Outcomes Research

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“…The risk to develop depression is highest in the first five years after RA diagnosis (Wang et al, 2014). Whilst pain is likely to contribute to the development of depression, the link between the severity of measurable parameters of arthritis and depression is less stringent.…”

Section: Rheumatoid Arthritis and Depression-like Symptomsmentioning

confidence: 99%

Depression in Autoimmune Diseases

Pryce

Fontana

2016

Current Topics in Behavioral Neurosciences

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Up to 50% of patients with autoimmune diseases show an impairment of health-related quality of life and exhibit depression-like symptoms. The immune system not only leads to inflammation in affected organs, but also mediates behavior abnormalities including fatigue and depression-like symptoms. This review focuses on the different pathways involved in the communication of the immune system with the neuronal network and the body's timing system. The latter is built up by a hierarchically organized expression of clock genes. As discussed here, the activation of the immune system interferes with high amplitude expression of clock genes, an effect which may play a pivotal role in depression-like behavior in autoimmune diseases.

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“…Also, previous studies comparing the prevalence of depression in the RA population versus healthy controls have produced heterogeneous effect sizes, which varied depending on the methods used . In the RA population, age‐ and sex‐specific estimates have rarely been reported for depression or for anxiety and other psychiatric comorbidities. As a measure of risk, incidence is more useful for the investigation of disease etiology than prevalence.…”

Section: Introductionmentioning

confidence: 99%

Increased Burden of Psychiatric Disorders in Rheumatoid Arthritis

Marrie

Hitchon

Walld

et al. 2018

Arthritis Care & Research

121

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ObjectiveWe estimated the incidence and prevalence of depression, anxiety disorder, bipolar disorder, and schizophrenia in a population‐based cohort with rheumatoid arthritis (RA) as compared to an age‐, sex‐, and geographically matched cohort without RA.MethodsUsing population‐based administrative health data from Manitoba, Canada, we identified persons with incident RA between 1989 and 2012, and a cohort from the general population matched 5:1 on year of birth, sex, and region of residence. We applied validated algorithms for depression, anxiety disorder, bipolar disorder, and schizophrenia to determine the annual incidence of these conditions after the diagnosis of RA, and their lifetime and annual period prevalence. We compared findings between cohorts using negative binomial regression models.ResultsWe identified 10,206 incident cases of RA and 50,960 matched individuals. After adjustment for age, sex, socioeconomic status, region of residence, number of physician visits, and year, the incidence of depression was higher in the RA cohort over the study period (incidence rate ratio [IRR] 1.46 [95% confidence interval (95% CI) 1.35–1.58]), as was the incidence of anxiety disorder (IRR 1.24 [95% CI 1.15–1.34]) and bipolar disorder (IRR 1.21 [95% CI 1.00–1.47]). The incidence of schizophrenia did not differ between groups (IRR 0.96 [95% CI 0.61–1.50]). Incidence rates of psychiatric disorders declined minimally over time. The lifetime and annual period prevalence of depression and anxiety disorder were also higher in the RA than in the matched cohort over the study period.ConclusionThe incidence and prevalence of depression, anxiety disorder, and bipolar disorder are elevated in the RA population as compared to a matched population.

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Risk of Developing Depressive Disorders following Rheumatoid Arthritis: A Nationwide Population-Based Study

Cited by 34 publications

References 54 publications

Healthcare burden of depression in adults with arthritis

Healthcare burden of depression in adults with arthritis

Depression in Autoimmune Diseases

Increased Burden of Psychiatric Disorders in Rheumatoid Arthritis

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