Risk of endometrial cancer among women with benign ovarian tumors — A Danish nationwide cohort study

Reinholdt, Kristian; Kjær, Susanne K.; Guleria, Sonia; Frederiksen, Kirsten; Mellemkjær, Lene; Munk, Christian; Jensen, Allan

doi:10.1016/j.ygyno.2020.02.032

Cited by 1 publication

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“…The risk of endometrial dysplasia combined with endometrial cancer is as high as 25.76 to 59.22% [9,10]. Clinically, there is a certain missed diagnosis rate in the diagnosis of EC [11]. How to identify high-risk patients with EC from patients with EH, is important to guide clinical treatment decisions and improve the prognosis of patients.…”

Section: Introductionmentioning

confidence: 99%

Risk factors of endometrial cancer in patients with endometrial hyperplasia: implication for clinical treatments

Zhao¹,

Hu²,

Zhao

et al. 2021

BMC Women's Health

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Background Endometrial hyperplasia (EH) is commonly-seen in the patients with endometrial cancer (EC), we aimed to evaluated the risk factors of EC in patients with EH, to provide evidence to the clinical prevention and treatment of EC. Methods This study was a retrospective study design. EH patients confirmed by pathological examinations and treated with hysterectomy in our hospital from June 1, 2018 to February 28, 2021 were included. The clinical characteristics of EC and no-EC patients were compared and analyzed. Logistics regression analyses were conducted to evaluate the risk factors of EC in patients with EH. Results A total of 228 EH patients were included, the incidence of EC in the EH patients was 31.58%. There were significant differences in the age, BMI, diabetes, hypertension and pathology of EH between EC and no EC groups (all P < 0.05), no significant differences in the hyperlipidemia, preoperative CA125, number of deliveries, menopause and endometrial thickness between EC and no EC groups were found (all P > 0.05). Logistic regression analyses indicated that age > 50 y (OR 3.064, 95% CI 1.945–5.931), BMI ≥ 25 kg/m2 (OR 2.705, 95% CI 1.121–3.889), diabetes (OR 3.049, 95% CI 1.781–5.114), hypertension (OR 2.725, 95% CI 1.108–3.431) and severe hyperplasia (OR 3.181, 95% CI 1.496–4.228) were the risk factors of EC in patients with EH (all P < 0.05). Conclusions The risk of EC in EH patients is high, especially for those patients with age > 50 y, BMI ≥ 25 kg/m2, diabetes, hypertension and severe hyperplasia, special attentions should be paid for occurrence of EC and early diagnosis and early treatment are needed for those patients.

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Section: Introductionmentioning

confidence: 99%