Risk of Esophageal Adenocarcinoma in Achalasia Patients, a Retrospective Cohort Study in Sweden

Zendehdel, Kazem; Nyrén, Olof; Edberg, Annika; Ye, Weimin

doi:10.1111/j.1572-0241.2007.01258.x

Cited by 19 publications

(27 citation statements)

References 19 publications

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“…[18][19][20][21][22] A recent study of 2,869 patients by Zendehdel and colleagues showed that men with achalasia have a standardized incidence ratio of 8.4 and 13.1 for adenocarcinoma and squamous cell cancer, respectively, compared with the general population. 23 Only one patient developed esophageal squamous cell carcinoma in our series, and our data suggests that cancer development in achalasia patients remains uncommon.…”

Section: Discussionmentioning

confidence: 83%

Laparoscopic Cardiomyotomy for Achalasia: Clinical Outcomes Beyond 5 Years

Chen

Bessell

Chew

et al. 2010

Journal of Gastrointestinal Surgery

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Section: Discussionmentioning

confidence: 83%

Laparoscopic Cardiomyotomy for Achalasia: Clinical Outcomes Beyond 5 Years

Chen

Bessell

Chew

et al. 2010

Journal of Gastrointestinal Surgery

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“…The risk of esophageal cancer in patients with achalasia was assessed by Zendehdel et al [4], who reported a higher incidence of esophageal cancer only in men with achalasia compared with the general population. Another report also indicated an increased risk of developing esophageal cancer in men with achalasia [2].…”

Section: Discussionmentioning

confidence: 99%

Esophageal squamous cell carcinoma co-existing with achalasia: report of two cases

et al. 2011

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Esophageal achalasia is a primary motility disorder of the esophagus. Although various treatments can relieve the symptoms, esophageal cancer arising in patients with achalasia is the most important problem for long-term survivors. We encountered 2 cases of esophageal squamous cell carcinoma co-existing with achalasia that had been diagnosed 27 and 30 years earlier, respectively. Neither patient had been aware of dysphagia due to dilatation of the esophagus. Both patients underwent esophagectomy via right thoracotomy. Although esophagectomy with radical lymphadenectomy was performed successfully in one case of submucosal cancer, the primary tumor in the other case was more invasive and aggressive than indicated by the preoperative clinical diagnosis, and could not be completely resected. Regular endoscopic examination should be scheduled for long-term survivors of achalasia in order to detect esophageal cancer early and evaluate any changes in the esophagus carefully.

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“…In sub category of predisposing factors, achalasia was identified as a risk factor for gastric cancer but in some studies achalasia was reported as a risk factor for esophageal cancer (Eckardt, 2010;Zendehdel et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Modeling of Influential Predictors of Gastric Cancer Incidence Rates in Golestan Province, North Iran

Behnampour¹,

Hajizadeh²,

Zayeri³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Golestan province has a reputation for relatively high incidence rates of gastric cancer in Iran. Along with dietary, lifestyle and environmental influential factors, soil selenium and high levels of pesticide used may exert influence in this region. The present study was designed for modeling the influential predictors on incidence of gastric cancer in Golestan. All registered cases of gastric cancer from March 2009 to March 2010 (49 females and 107 males) were investigated. Data were gathered by both check list and researcher made questionnaire (demographic, clinical and lifestyle characteristics) and analysed using logistic regression. Mean (±SD) age at diagnosis was 62.9±13.8 years. CIR and ASR of gastric cancer showed 9.16 and 13.9 per 100,000 people, respectively. Based on univariate logistic regression, a history of smoking (OR= 2.076), unwashed hands after defecation (OR= 2.612), history of cancer in relatives (OR= 2.473), history of gastric cancer in first-degree relatives (OR= 2.278), numbers of gastric cancers in first-degree relatives (OR= 2.078), history of X-ray and dye exposure (OR= 2.395), history of CT scan encounter (OR= 2.915), improper food habits (OR= 3.320), specific eating behavior (OR= 0.740), consumption of probable high risk foods (OR= 2.942), charred flesh (OR= 1.945), and animal fat (OR= 2.716) were confirmed as a risk factors. Changes in lifestyle may be expected to increase gastric cancer incidence dramatically in the near future. Therefore, appropriate educational interventions should be designed and implemented by competent authorities

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Risk of Esophageal Adenocarcinoma in Achalasia Patients, a Retrospective Cohort Study in Sweden

Cited by 19 publications

References 19 publications

Laparoscopic Cardiomyotomy for Achalasia: Clinical Outcomes Beyond 5 Years

Laparoscopic Cardiomyotomy for Achalasia: Clinical Outcomes Beyond 5 Years

Esophageal squamous cell carcinoma co-existing with achalasia: report of two cases

Modeling of Influential Predictors of Gastric Cancer Incidence Rates in Golestan Province, North Iran

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