Risk of female breast cancer and serum concentrations of organochlorine pesticides and polychlorinated biphenyls: A case–control study in Tunisia

Arrebola, Juan Pedro; Belhassen, H.; Artacho‐Cordón, Francisco; Ghali, R.; Ghorbel, H.; Boussen, Hamouda; Pérez-Carrascosa, Francisco Miguel; Expósito, José; Hédhili, Abderrazek; Olea, Nicolás

doi:10.1016/j.scitotenv.2015.03.045

Cited by 103 publications

(49 citation statements)

References 73 publications

(80 reference statements)

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“…There is strong evidence on the association with a wide range of diseases and exposure to pesticides (11). Exposure to organochlorine pesticides may result in health-related complications including reproductive defects (12,13), carcinogenic effects (14) breast cancer risk (15) and behavioral changes (16). Organochlorinated pesticides are chlorinated hydrocarbons that are composed primarily of carbon, hydrogen and several chlorine atoms per molecule (16,17).…”

Section: Organochlorinated Pesticidementioning

confidence: 99%

A Systematic Review of Organochlorinated Pesticide Residues in Caspian Sea Fishes

Zazouli

Safarpour

2016

Health Scope

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Context: The worldwide production and application of pesticides, especially organochlorine in agriculture can have adverse environmental pollution and human health risks. Thus, this review evaluated and summarized the toxicological data on the existence and concentrations of organochlorine compounds in Caspian sea fish tissues.Evidence Acquisition: The data were collected from published articles in PubMed, ISI, SID, Google Scholar and so on. Results: The review showed that nine studies were recorded in databases about pesticide residues in Caspian sea fish tissues. These studies reported that there is limited evidence of organochlorinated compounds in Caspian sea fishes. All researchers detected organochlorine contaminants in examined fishes in the studied area, however DDTs was the predominant pesticides. Heptachlor, Polychlorinated Biphenyls (PCBs) and Linden were ranked next, respectively. Conclusions:In conclusion, toxicological studies showed that, although contamination level in Caspian sea fishes was relatively low, the present status might pose a risk about food chain contamination.Keywords: Pesticide Residues, Fish, Environmental Toxicology, Systematic Review, DDTs Context Caspian SeaThe Caspian sea (CS) with a volume and surface area of 78000 km 3 and 380000 km 2 , respectively, is the biggest land body of water in the world and a unique system that is surrounded by five countries: Iran (900 km), Azerbaijan, Turkmenistan, Kazakhstan and Russia (1). The Caspian sea has about 130 river inputs, but no output (1-3). Various pollutants have accumulated in the Caspian sea due to many human activity sewages, agricultural and industrial waste flowing into the landlocked system, which threaten directly or indirectly environment and human health especially through the food chain (4, 5). Organochlorinated PesticideThe use of pesticides and fertilizers has been substantially increased to increase additional production of crops around the world as a consequence of increased human population (6-8). In spite of the potential to prevent and control insects, disease vector and weed, some pesticides such as Organochlorine pesticides (OCs) can be toxic to human health, wildlife and have deleterious impacts on the environment (9, 10). There is strong evidence on the association with a wide range of diseases and exposure to pesticides (11). Exposure to organochlorine pesticides may result in health-related complications including reproductive defects (12, 13), carcinogenic effects (14) breast cancer risk (15) and behavioral changes (16). Organochlorinated pesticides are chlorinated hydrocarbons that are composed primarily of carbon, hydrogen and several chlorine atoms per molecule (16,17). Due to their hydrophobic characteristics, resistance to degradation, toxicity, least solubility in water, bioaccumulative nature, low vapour pressures and long-range transport and trans-boundary dispersion, the control of OCs in the environment is a real necessity (6,(17)(18)(19). Some of the most representative compounds in this...

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Section: Organochlorinated Pesticidementioning

confidence: 99%

A Systematic Review of Organochlorinated Pesticide Residues in Caspian Sea Fishes

Zazouli

Safarpour

2016

Health Scope

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“…These studies all had one thing in commonthey were measuring DDTs in women diagnosed with breast cancer at or near the time of diagnoses. However, studies in Colombia (43), Tunisia (44), and Mexico City (45) have demonstrated an elevated risk of breast cancer in women with higher serum DDE.…”

Section: Ddt and Related Chemicalsmentioning

confidence: 99%

Timing of Environmental Exposures as a Critical Element in Breast Cancer Risk

Fenton

Birnbaum

2015

The Journal of Clinical Endocrinology & Metabolism

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Evidence has accumulated for several chemicals that environmental factors have a stronger effect on breast cancer risk when exposure occurred early in life. The insecticide, dichlorodiphenyltrichloroethane, is an excellent example and is just one of several chemicals for which there seems to be both animal and human evidence for the developmental basis of adult disease. The developing breast undergoes many changes in early life, leaving it vulnerable to the effects of epigenetic marks, endocrine disruption, and carcinogens. More research is needed in the area of early beginnings of breast cancer, with prevention of the disease as the ultimate goal.

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“…PCBs have been classified as carcinogenic to humans by the IARC (Lauby-Secretan et al, 2013) and have been linked to many health concerns involving the reproductive (Buck Louis et al, 2009), endocrine (Hagmar, 2003;Luzardo et al, 2012b), neurological (Longnecker et al, 2003), immune system (Tsuji, 2015) and cancer (Arrebola et al, 2015). Although most studies devoted to evaluate adverse health effects exerted by these pollutants in humans have been performed in series of occupationally exposed people or in subjects affected by acute intoxications (Yorifuji et al, 2013), a number of adverse health effects have been also described in general population in relation to chronic environmental exposure to PCBs (Carpenter, 2006;Vaiserman, 2014).…”

Section: Introductionmentioning

confidence: 99%

Relationship of polychlorinated biphenyls (PCBs) with parasitism, iron homeostasis, and other health outcomes: Results from a cross-sectional study on recently arrived African immigrants

Henríquez-Hernández

Boada

Pérez-Arellano

et al. 2016

Environmental Research

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Risk of female breast cancer and serum concentrations of organochlorine pesticides and polychlorinated biphenyls: A case–control study in Tunisia

Cited by 103 publications

References 73 publications

A Systematic Review of Organochlorinated Pesticide Residues in Caspian Sea Fishes

A Systematic Review of Organochlorinated Pesticide Residues in Caspian Sea Fishes

Timing of Environmental Exposures as a Critical Element in Breast Cancer Risk

Relationship of polychlorinated biphenyls (PCBs) with parasitism, iron homeostasis, and other health outcomes: Results from a cross-sectional study on recently arrived African immigrants

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