Risk of gastric cancer in Helicobacter pylori infection in a 15-year follow-up

Abstract

Objective: We investigated the risk of gastric cancer among men with Helicobacter pylori (H. pylori) infection or atrophic gastritis (AG) in a 15-year follow-up. Materials and methods: Study population consists of 12,016 men aged 50–65 years at the beginning of the follow-up in 1994–1996. Serum levels of pepsinogen I (SPGI) and antibodies (IgG) to H. pylori (HpAb) were assayed from serums collected in 1994–1996. Incidence of gastric cancer in the study population was assessed in follow-up from 1994 to 2011 by data from the nationwide cancer registry. Based on SPGI and HpAb values, standardized incidence ratios (SIRs) of gastric cancer were calculated in three subgroups, that is, in those with a healthy stomach, those with H. pylori infection but without AG and those with AG. Risk ratios (RR) of gastric cancer were calculated using SIR of subgroups. Results: During 15 years, seven gastric cancers appeared per 79,928 person years among men with healthy stomachs, 50 cancers per 92,533 person years in men with H. pylori infection but without AG, and 8 per 8658 person years in men with AG. Risk ratio (RR) of stomach cancer in men with H. pylori infection was 5.8 (95%CI: 2.7–15.3) compared to men with healthy stomachs, and 9.1 (95%CI: 2.9–30.0) in men with AG. There were no differences in cancer risk between cardia and distal stomach. Conclusions: Risk of gastric cancer is low in men with healthy stomachs. It is significantly increased in those with H. pylori infection and more in those with AG.

Polyamine- and NADPH-dependent generation of ROS during Helicobacter pylori infection: A blessing in disguise

“…Although H. pylori potentially confers protection against diseases, notably in childhood [1], long-term infection has been associated with the development of chronic active gastritis. Moreover, approximately 10% of H. pylori -infected patients develop peptic ulcer disease, less than 0.1% develop mucosa-associated lymphoid tissue lymphoma, and 1 to 3% develop gastric adenocarcinoma [2, 3], the third leading cause of death by cancer worldwide corresponding to 10% of total cancer-related mortality. Therefore, H. pylori is considered as the most common etiologic agent of infection-related cancers and has been classified as a class I carcinogen.…”

Inhibitory Effects of β-Caryophyllene on Helicobacter pylori Infection In Vitro and In Vivo

“…Helicobacter pylori (H. pylori) is a Gram-negative, spiral-shaped, microaerophilic bacterium that selectively colonizes in human gastric mucosa [1,2]. Compared with uninfected individuals, H. pylori infected individuals have a 2−8-fold increased risk of developing gastric cancer [3]. For these reasons, H. pylori has been classified as class I carcinogen by the World Health Organization (WHO) [4].…”

Prevalence of Helicobacter pylori infection among blood donors in Saxony-Anhalt, Germany – a region at intermediate risk for gastric cancer

“…Helicobacter pylori infection is the main risk factor for gastric cancer (GC) [1]. A recent Finnish study referred that the risk of GC is approximately 6 times higher with H. pylori infection than without [2]. Stomach cancer without evidence of H. pylori is rare.…”