2021
DOI: 10.1186/s12889-021-11846-x
|View full text |Cite
|
Sign up to set email alerts
|

Risk of HBV infection among male and female first-time blood donors born before and after the July 1986 HBV vaccination program in Taiwan

Abstract: Background In July 1984, Taiwan officially began a nationwide hepatitis B virus (HBV) vaccination program where only infants born to HBsAg-positive mothers were vaccinated free of charge until June 1986. However, from July 1986, all infants were vaccinated against HBV. The impact of the July 1986 HBV vaccination program on first-time blood donors has not been exhaustively studied. We, therefore, determined the risk of HBV among male and female first-time blood donors born before and after the J… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
4

Citation Types

0
4
0

Year Published

2022
2022
2024
2024

Publication Types

Select...
6

Relationship

0
6

Authors

Journals

citations
Cited by 7 publications
(4 citation statements)
references
References 50 publications
0
4
0
Order By: Relevance
“…19 Therefore, HBV vaccination is a cost-effective and reliable method to reduce HBV infections. 20 Nevertheless, if cirrhosis was diagnosed, there was a risk of HCC even after successful antiviral therapy. 21 The results of our study indicated that cirrhosis can increase the risk of HCC by more than tenfold.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…19 Therefore, HBV vaccination is a cost-effective and reliable method to reduce HBV infections. 20 Nevertheless, if cirrhosis was diagnosed, there was a risk of HCC even after successful antiviral therapy. 21 The results of our study indicated that cirrhosis can increase the risk of HCC by more than tenfold.…”
Section: Discussionmentioning
confidence: 99%
“…A previous cohort study conducted in Taiwan showed that vaccination of infants reduced the incidence of HCC from 0.92 to 0.23/10 5 person‐years 19 . Therefore, HBV vaccination is a cost‐effective and reliable method to reduce HBV infections 20 . Nevertheless, if cirrhosis was diagnosed, there was a risk of HCC even after successful antiviral therapy 21 .…”
Section: Discussionmentioning
confidence: 99%
“…This observation was consistent with results obtained from Blood Transfusion Center of Tartus ( 20 ) and among multi-transfused Patients with Hemoglobinopathy ( 17 ). Moreover, the deterioration of the immune system, termed immunosenescence, is related to aging, which makes older people more vulnerable to infections ( 33 ). Worth mentioning, the dropping in the coverage of the HBV vaccination during the Syrian crisis from 84% in 2010 to 42% in 2016 ( 34 ) may lead to a surge in infections in some territories of the country in the upcoming years.…”
Section: Discussionmentioning
confidence: 99%
“…This gender disparity might be partly due to the fact that males are ~1.5 times more likely to develop chronic HBV infection than females as a result of the slower plasma clearance rate of HBsAg in males compared to females. Moreover, some studies suggested a genetic determinant of disease development mainly regulated by sex hormones ( 28 , 33 , 35 ). Furthermore, the higher TTVIs prevalence in male donors may be attributed to more strict behavioral, religious and socio-cultural constraints on female premarital sex that are typically imposed on women in conservative societies.…”
Section: Discussionmentioning
confidence: 99%