Risk of Head and Neck Cancer in Patients With Diabetes Mellitus

Tseng, Kuo Shu; Lin, Charlene; Lin, Yong-Song; Weng, Shih‐Feng

doi:10.1001/jamaoto.2014.1258

Cited by 67 publications

(35 citation statements)

References 45 publications

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“…The comparison non-DM cohort was 1-to-1 matched with the DM cohort by age, sex, index date, and comorbidities with a minimum 2 visits. [ 23 ] The comorbidities included coronary artery disease (CAD) (410–414, A270, and A279), hyperlipidemia (272), hypertension (401–405), chronic kidney disease (CKD) (585), chronic obstructive pulmonary disease (COPD) (490–496, a surrogate for smoking), and obesity (278.0 and V778). The immunosuppression status is also an important risk factor of skin cancer.…”

Section: Methodsmentioning

confidence: 99%

Risk of skin cancer in patients with diabetes mellitus

et al. 2016

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Increasing evidence suggests that certain types of cancers are more common in people with diabetes mellitus (DM). This study aimed to investigate the risk of skin cancer in patients with DM in Taiwan. In this retrospective cohort study using data from the Taiwan Longitudinal Health Insurance Research Database, the risk of developing overall skin cancer, including nonmelanoma skin cancer (NMSC) and melanoma, was compared by Poisson regression analysis and Cox regression analysis between the DM and non-DM cohorts. The DM cohort with newly diagnosed DM (n = 41,898) and a non-DM cohort were one-to-one matched by age, sex, index date, and comorbidities (coronary artery disease, hyperlipidemia, hypertension, chronic kidney disease, chronic obstructive pulmonary disease, and obesity). Compared with non-DM cohort statistically, for the people with DM aged ≥60 years, the incidence rates of overall skin cancer and NMSC were significantly higher (overall: DM/non-DM: number [n] = 99/76, incidence rate ratio [IRR] = 1.44, P = 0.02; NMSC: DM/non-DM: n = 94/66, IRR = 1.57, P = 0.005). By Cox regression analysis, the risk of developing overall skin cancer or NMSC was significantly higher after adjusting for sex, comorbidities, and overall diseases with immunosuppression status (overall: adjusted hazard ratio [AHR] = 1.46, P = 0.01; NMSC: AHR = 1.6, P = 0.003). Other significant risk factors were older males for skin cancer (overall: AHR = 1.68, P = 0.001; NMSC: AHR = 1.59, P = 0.004; melanoma: AHR = 3.25, P = 0.04), chronic obstructive pulmonary disease for NMSC (AHR = 1.44, P = 0.04), and coronary artery disease for melanoma (AHR = 4.22, P = 0.01). The risk of developing melanoma was lower in the DM cohort than in the non-DM cohort, but without significance (AHR = 0.56, P = 0.28; DM/non-DM: n = 5/10). The incidence rate and risk of developing overall skin cancer, including NMSC, was significantly higher in older adults with DM. Other significant risk factors for older adults with DM were males for NMSC and melanoma, chronic obstructive pulmonary disease for NMSC, and coronary artery disease for melanoma.

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Section: Methodsmentioning

confidence: 99%

Risk of skin cancer in patients with diabetes mellitus

et al. 2016

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“…Second, lifestyle information such as consumption, smoking habit, betel nut chewing, dietary habits, and data of family history was lacking in the present study and might have some bias. However, based on Yeh 38 and Tseng's 39 studies, we added the adjustment of smoking-related disease and the alcohol-related diseases to reduce smoking and alcoholism related confounder. Third, based on ICD-9 code, we cannot distinguish histologic types of cancer.…”

Section: Strengths and Limitationsmentioning

confidence: 99%

Association of Head and Neck Cancers in Chronic Osteomyelitis

Tsai

Lin

et al. 2016

Medicine

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The aim of study is to determine whether chronic osteomyelitis (COM) is linked to an increased risk of head and neck cancer (HNC).We identify 17,033 patients with osteomyelitis and 68,125 subjects without osteomyelitis during 1996 to 2010 periods. Multivariable Cox proportional hazards regression analysis was used to measure the hazard ratio (HR) of head and neck cancer for the osteomyelitis cohort compared with the comparison cohort.A total of 99 patients in the COM and 228 patients in the comparison cohort developed HNC during an average 5.12 years of follow-up period. The incidence rate of HNC in the COM cohort was 1.51-fold (95% confidence interval [CI]: 1.17–1.95) higher than that in the comparison cohort after adjusting gender, age, urbanization level, monthly income, and comorbidities. In subgroup analysis, younger (less than 45 years-old) and patients without comorbidities have greater risks (adjusted HR: 2.29 [95% CI:1.43-3.66] and 1.74 [95% CI:1.28-2.38] respectively).This study results suggested the association between COM and HNC, particularly in younger population and patients without comorbidities.

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“…Three studies were conducted in Southeast Asia, and one in Europe. Matched design was introduced in two studies, 16 , 18 and three studies used multivariate analysis to calculate ORs. 16 – 18 Hsieh et al reported ORs from three subgroups instead of the whole cohort.…”

Section: Resultsmentioning

confidence: 99%

Impact of diabetes mellitus on the risk and survival of nasopharyngeal carcinoma: a meta-analysis

Guo¹,

Fu²,

Wei³

et al. 2018

OTT

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BackgroundDiabetes mellitus (DM) has been identified to be both a risk factor and a prognostic factor in a variety of malignancies, but its association with the risk and outcome of nasopharyngeal carcinoma (NPC) is still unclear. To elucidate this issue, we systematically reviewed the evidence concerning the association between DM status and NPC.Materials and methodsWe identified studies by a literature search of PubMed, Embase, and ISI Web of Knowledge through May 31, 2017, and by searching the reference lists of pertinent articles. Odds ratios (ORs) and hazard ratios (HRs) with 95% CIs were used to estimate the effect size. Heterogeneity across studies was evaluated by the Cochran’s Q and I2 statistics.ResultsA total of nine studies were included. Four studies with a total sample size of 221,611 reported the effect of DM on NPC risk, and the other five studies with a sample size of 9,442 reported the impact of DM on survival in NPC patients. All included studies were retrospective, and mostly conducted in Asian populations. Meanwhile, condition of metformin usage was not considered in all studies. A pooled OR of 0.65 (95% CI: 0.43–0.98, P=0.04) revealed an inverse association between DM and NPC. Additionally, pooled analyses of studies investigating the prognosis value of DM revealed that preexisting DM had no effect on overall survival (HR =1.17, 95% CI: 0.94–1.46, P=0.16), local recurrence-free survival (HR =1.16, 95% CI: 0.80–1.67, P=0.44), and distant metastasis-free survival (HR =1.14, 95% CI: 0.92–1.40, P=0.22).ConclusionOur results suggested that DM patients might have decreased NPC risk, and have little impact on prognosis of NPC patients. This conclusion should be limited to Asian population. Our results also suggest that more attention should be paid to metformin medication in further studies in order to clarify whether the effects of DM on NPC risk and prognosis are influenced by the anticancer effect of metformin.

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Risk of Head and Neck Cancer in Patients With Diabetes Mellitus

Abstract: Diabetes is associated with an increased risk of developing HNC. The risks of developing oral cavity cancer, oropharyngeal cancer, and nasopharyngeal carcinoma were significantly higher in patients with DM.

Cited by 67 publications

References 45 publications

Risk of skin cancer in patients with diabetes mellitus

Risk of skin cancer in patients with diabetes mellitus

Association of Head and Neck Cancers in Chronic Osteomyelitis

Impact of diabetes mellitus on the risk and survival of nasopharyngeal carcinoma: a meta-analysis

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