2012
DOI: 10.1016/j.clinthera.2012.05.008
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Risk of Hemorrhage and Treatment Costs Associated With Warfarin Drug Interactions in Patients With Atrial Fibrillation

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Cited by 23 publications
(35 citation statements)
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“…Patients who used these medications had a 26 % higher risk of haemorrhage than those who did not use these drugs. The likelihood of haemorrhagic events was significantly increased with the use of potentiating drugs from the following therapeutic classes: anticoagulants (OR1.91), anti-infectives (OR1.76), antiplatelets (OR1.56) and analgesics (OR1.33) [60]. In another recent retrospective study in an elderly population (n017,600) who used warfarin, bleedingrelated hospitalization rates were significantly increased when warfarin was co-prescribed with aspirin (AdjRR 1.…”
Section: Discussionmentioning
confidence: 99%
“…Patients who used these medications had a 26 % higher risk of haemorrhage than those who did not use these drugs. The likelihood of haemorrhagic events was significantly increased with the use of potentiating drugs from the following therapeutic classes: anticoagulants (OR1.91), anti-infectives (OR1.76), antiplatelets (OR1.56) and analgesics (OR1.33) [60]. In another recent retrospective study in an elderly population (n017,600) who used warfarin, bleedingrelated hospitalization rates were significantly increased when warfarin was co-prescribed with aspirin (AdjRR 1.…”
Section: Discussionmentioning
confidence: 99%
“…The primary outcomes were inpatient admissions for acute ischemic stroke or major bleeding, as defined by Rothendler et al 21 and Suh et al 22 based on the primary ICD-9-CM diagnosis on inpatient SAF claims for acute care stays. The secondary outcomes were subdivisions of major bleeding, defined as intracranial hemorrhage (ICH, including hemorrhagic stroke), gastrointestinal hemorrhage (GIH), and other major non-GIH, based on previously published algorithms.…”
Section: Methodsmentioning
confidence: 99%
“…Other comorbid conditions were identified in inpatient and outpatient claims during the 12 months prior to the first AF diagnosis date and were defined using algorithms originally developed by Elixhauser et al (18). Previous cerebrovascular events and prior bleeding episodes were identified using previously published algorithms (19,20). …”
Section: Methodsmentioning
confidence: 99%