Risk of Herpes Zoster in Relation to Body Mass Index Among Residents Aged ≥50 Years: The Shozu Herpes Zoster Study

Kawahira, Kazuhiro; Imano, Hironori; Yamada, Keiko; Takao, Yukiko; Mori, Yasuko; Asada, Hideo; Okuno, Yoshinobu; Yamanishi, Koichi; Iso, Hiroyasu

doi:10.2188/jea.je20200473

Cited by 7 publications

(6 citation statements)

References 19 publications

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“…BMI was positively correlated with higher CD4+ count and CD4+/CD8+ ratio, 44 and psychological distress may influence human immune function, particularly in women 45 . These immunological mechanisms are consistent with our previous research that overweight women had a lower risk of HZ incidence 21 …”

Section: Discussionsupporting

confidence: 91%

“…45 These immunological mechanisms are consistent with our previous research that overweight women had a lower risk of HZ incidence. 21 HZ is preventable by vaccination, and the freeze-dried recombinant HZ vaccine is recommended for older people in some developed countries (e.g., the United States). However, this vaccine is expensive to distribute in developing countries.…”

Section: Ta B L E 3 (Continued)mentioning

confidence: 73%

“…BMI was calculated as bodyweight divided by the square of the height (both self‐reported), expressed in units of kg/m 2 . We defined BMI ≥ 25 kg/m 2 as overweight—a potential predictor because in a previous study our group identified that being overweight reduced the risk of HZ incidence in women in the same data set 21 …”

Section: Methodsmentioning

confidence: 99%

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Predictors of herpes zoster severity and immune responses according to pain trajectories: A community‐based prospective cohort study

Yamada

Mori

Cui

et al. 2023

The Journal of Dermatology

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The authors aimed to identify determinants of the clinical course of herpes zoster and immunological responses, focusing on pain trajectories. This prospective communitybased cohort study involved the analysis of responses to a valid pain survey provided by 375 patients diagnosed with herpes zoster based on clinical symptoms and virus identification by polymerase chain reaction. The authors analyzed most patients for humoral/ cell-mediated immune response against varicella-zoster virus at the onset and 3 months post-onset. Six months post-initial visit, patients self-reported pain on a scale of 0 (no pain) to 5 (extremely strong pain) at up to 18 time points. Moreover, the pain trajectories were traced using group-based trajectory modeling. Subsequently, the authors used analysis of covariance to explore predictors and the humoral/cell-mediated immune response according to the pain trajectories. In addition, humoral/cell-mediated immune responses were assessed among each trajectory using paired t tests. Amon the five identified trajectories, two were isolated that particularly developed postherpetic neuralgia, with or without severe acute pain. Cancer therapy and corticosteroid use before herpes zoster onset specifically predicted postherpetic neuralgia without severe acute pain. In contrast, prescription of nonsteroidal anti-inflammatory drugs was uniquely associated with postherpetic neuralgia accompanied by severe acute pain. The aforementioned trajectories with postherpetic neuralgia showed increased antibodies and decreased cell-mediated immunity compared with those without postherpetic neuralgia. The authors could successfully distinguish between postherpetic neuralgia trajectories with and without severe acute pain. The identified key predictors and immunological responses against varicellaherpes zoster contribute further evidence to our understanding of the clinical features of herpes zoster and postherpetic neuralgia.

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Section: Discussionsupporting

confidence: 91%

Section: Ta B L E 3 (Continued)mentioning

confidence: 73%

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Predictors of herpes zoster severity and immune responses according to pain trajectories: A community‐based prospective cohort study

Yamada

Mori

Cui

et al. 2023

The Journal of Dermatology

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“…A logistic regression model was applied to obtain the odds ratios and 95% confidence intervals (CIs) of a positive VZV test according to past history of HZ, adjusting for potential confounding variables such as age, sex, body mass index, smoking status sleep duration, and mental stress. [16][17][18][19] For follow-up analysis, we applied a Cox proportional hazard regression model to obtain hazard ratios and 95% CIs of incident HZ according to past history of HZ, adjusting for age, sex, body mass index, smoking, sleep duration, and mental stress. All statistical analyses were two-tailed and P < 0.05 was considered statistically significant.…”

Section: Discussionmentioning

confidence: 99%

Risk of herpes zoster according to past history in the general population: The Japanese Shozu herpes zoster study

Kawahira

Imano

Yamada

et al. 2023

The Journal of Dermatology

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Immunity is known to persist after vaccination for varicella zoster virus, but the duration of immunity in patients who develop herpes zoster (HZ) remains unknown. To investigate the association between a past history of HZ and its occurrence in the general population. The Shozu HZ (SHEZ) cohort study included data for 12 299 individuals aged ≥50 years with information on their HZ history. Cross‐sectional and 3‐year follow‐up studies were carried out to analyze the associations between a history of HZ (yes <10 years, yes ≥10 years, no) and the proportion of positive varicella zoster virus skin test results (erythema diameter ≥5 mm) and the risk of HZ after adjusting for potential confounding factors including age, sex, body mass index, smoking status, sleep duration, and mental stress. The incidences of positive skin test results were 87.7% (470/536) for individuals with a history of HZ <10 years ago, 82.2% (396/482) for those with a history of HZ ≥10 years, and 80.2% (3614/4509) for those with no history of HZ. The multivariable odds ratios (95% confidence intervals) of erythema diameter ≥5 mm were 2.07 (1.57–2.73) and 1. 39 (1.08–1.80) for individuals with a history <10 years and ≥10 years ago, respectively, compared with no history. The corresponding multivariable hazard ratios of HZ were 0.54 (0.34–0.85) and 1.16 (0.83–1.61), respectively. A past history of HZ <10 years ago may reduce the occurrence of HZ.

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“…Potential confounding variables other than age and sex were lower body mass index (BMI) [ 13 ], smoking [ 14 ], drinking [ 15 ], mental stress [ 16 ], motivation [ 16 ], negative life event [ 16 ], underlying diseases such as hypertension, hyperlipidemia, diabetes mellitus [ 17 ], cancer [ 18 ], and connective tissue diseases [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

The association of family history of herpes zoster and the risk of incident herpes zoster: the SHEZ Study

Kinumaki

Imano

Takao

et al. 2022

Environ. Health Prev. Med.

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Background We investigated whether family histories of herpes zoster (HZ) are associated with the risk of incident HZ in a Japanese population. Methods A total of 12,522 Japanese residents aged ≥50 years in Shozu County participated in the baseline survey between December 2008 and November 2009 (the participation rate = 72.3%). They were interviewed at baseline by research physicians regarding the registrants’ history of HZ. A self-administered questionnaire survey was conducted to evaluate the potential confounding factors. 10,530 participants without a history of HZ were followed up to ascertain the incidence of HZ during 3-years follow-up until the end of November 2012 with Japanese nationals. We estimated hazard ratios (HRs) of incident HZ according to first-degree family histories using the Cox proportional hazard regression after adjusting for age, sex, and other potential confounding factors. Results Compared to no HZ history of each family member, a history of brother or sister was associated with a higher risk of incident HZ while histories of father and mother were not. The multivariable HR (95%CI) of incident HZ for a history of brother or sister was 1.67 (1.04–2.69). When comparing to no family histories of all first-degree relatives, the multivariable HRs (95%CIs) were 1.34 (0.77–2.34) for a history of brother or sister alone, but 4.81 (1.78–13.00) for a history of mother plus brother or sister. As for the number of family histories, the multivariable HRs (95%CIs) were 1.08 (0.76–1.54) for one relative (father, mother, or brother or sister) and 2.75 (1.13–6.70) for two or more relatives. Conclusion Family histories of mother plus brother or sister and two or more first-degree relatives were associated with a higher risk of incident HZ.

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Risk of Herpes Zoster in Relation to Body Mass Index Among Residents Aged ≥50 Years: The Shozu Herpes Zoster Study

Cited by 7 publications

References 19 publications

Predictors of herpes zoster severity and immune responses according to pain trajectories: A community‐based prospective cohort study

Predictors of herpes zoster severity and immune responses according to pain trajectories: A community‐based prospective cohort study

Risk of herpes zoster according to past history in the general population: The Japanese Shozu herpes zoster study

The association of family history of herpes zoster and the risk of incident herpes zoster: the SHEZ Study

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