Risk of Hodgkin's Disease and Other Cancers After Infectious Mononucleosis

Hjalgrim, Henrik

doi:10.1093/jnci/92.18.1522

Cited by 122 publications

(89 citation statements)

References 30 publications

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“…The positive association observed between HL and a history of mononucleosis was expected and of the same order of magnitude than that estimated by Hjalgrim et al 6 (standardized incidence ratio ¼ 2.55 [1.87-3.40]) from the follow-up of cohorts of mononucleosis patients.…”

supporting

confidence: 80%

History of infections and vaccinations and risk of lymphoid neoplasms: does influenza immunization reduce the risk?

et al. 2007

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supporting

confidence: 80%

History of infections and vaccinations and risk of lymphoid neoplasms: does influenza immunization reduce the risk?

et al. 2007

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“…The lack of an association of HD with IM in our population overall contradicts findings from several other US and European studies. 9,[23][24][25] The relatively high prevalence of IM reported by our study subjects (near 20%) may indicate that this factor, like others studied here, no longer measures the critical delayed exposure to infection postulated from earlier findings.…”

supporting

confidence: 40%

Social class and risk of Hodgkin's disease in young‐adult women in 1988–94

Glaser

Clarke

Nugent

et al. 2001

Intl Journal of Cancer

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Hodgkin's disease (HD) risk in young adults has been associated with higher childhood social class. Although recent decades have witnessed increases in both young-adult HD incidence rates and the socioeconomic affluence reported to influence risk, social class risk factors have not been reexamined. For 204 cases and 254 controls aged 19 -44 years from a population-based case-control study of HD diagnosed in 1988 -94 in San Francisco area females, we evaluated social class predictors of HD overall and for subgroups defined by age and by ethnicity. HD was associated weakly with a few childhood social class markers but more strongly with combinations of these variables. Risk was higher for women with family-owned than rented childhood homes; for US-born women with single vs. shared bedrooms at age 11; and for women with 2؉ births who were from smaller than larger childhood households. These patterns differed by age, with risk appearing to increase over the young-adult years for some factors and to decrease for others. In whites, risk was additionally associated with having a single childhood bedroom in larger households, and with tall adult height in women from smaller childhood households. In nonwhites, risk was higher for single bedrooms at age 11 in smaller childhood households, taller height and higher maternal education. Most study findings support the hypothesis that HD development in young adults follows protection from early exposure to other children. Variation in risk by age suggests differing etiologies across young adulthood, or the importance of birth cohort-appropriate social-class measures. Negative findings for previously reported risk factors may reflect their insufficient heterogeneity of exposure or their failure to measure cohort-relevant exposures in this population. © 2002 Wiley-Liss, Inc. Key words: Hodgkin's disease; social class; women; epidemiology; risk factorsIn the 1960s and 1970s, observations that social class indicators were associated with Hodgkin's disease (HD) provided support for MacMahon's hypothesis that infectious agents were involved in the etiology of this lymphoma in young adults. [1][2][3][4][5][6][7] In a Boston population in the mid 1970s, Gutensohn and Cole 8 found that HD risk in young adults was linked to small sibships, early birth order, single-family housing, few playmates and higher maternal education in childhood. Collectively, these childhood social class factors described diminished contact with children and thus suggested that HD etiology involves delay in exposure to common childhood infections until older childhood or adolescence, when such illnesses may be more virulent. This interpretation has been supported by the association of HD with a history of infectious mononucleosis (IM), a clinical manifestation of late-onset primary infection with Epstein-Barr virus (EBV). 9 In the 20 years after the mid-1970s, the incidence of young-adult HD rose in the US, particularly in women. 10,11 Between 1975-79 and 1990 -94, 5-year average annual rates for white women a...

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“…Clinical manifestations of EBV infections vary according to age, ranging from silent infections in infants to infectious mononucleosis in adolescents and adults. In addition, many serological and molecular studies have provided evidence that EBV is associated with various types of malignancies such as lymphoma, nasopharyngeal carcinoma (NPC), Hodgkin disease and gastric carcinoma (Cohen et al, 2008;Hjalgrim et al, 2000;Mitarnun et al, 2004;Piriou et al, 2012;Tiwawech et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Seroprevalence of Anti-EBV IgG among Various Age Groups from Khon Kaen Province, Thailand

Suntornlohanakul¹,

Wanlapakorn²,

Vongpunsawad³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Epstein-Barr virus (EBV) is an extremely common herpesvirus that may cause asymptomatic infection or various diseases, including infectious mononucleosis, certain lymphoproliferative diseases and several types of neoplasms. Vaccine development is an important strategy to reduce the burden of EBV-associated diseases and the timing of vaccinations should be before primary infection occurs. In the past, more than 90% of Thai children were infected with EBV in early childhood. Now, due to the improved healthcare system in Thailand, we aim to determine current prevalence of EBV infection among people in different age groups. A total of 538 sera were collected from residents of Khon Kaen province in northeastern Thailand for detecting anti-EBV IgG. Sera of infants under 2-years-old were also tested for anti-EBV IgM and EBV-DNA. The prevalence of anti-EBV IgG was 47.1% (95% CI: 23.3-70.8) in infants aged 0-6 months, 34.9% (95% CI: 23.1-46.7) in those aged 6-24 months, 87.9% (95% CI: 79.5-96.3) in children aged 3-5 years and then maintained at above 95% through adulthood. These seropositivity rates among Thai children remain similar to those found in a previous study conducted 20 years ago. Thai children are still exposed to EBV from an early age. Therefore, a prophylactic vaccine should be given within the first two years of life.

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Risk of Hodgkin's Disease and Other Cancers After Infectious Mononucleosis

Abstract: The increased risk of Hodgkin's disease after the occurrence of infectious mononucleosis appears to be a specific phenomenon.

Cited by 122 publications

References 30 publications

History of infections and vaccinations and risk of lymphoid neoplasms: does influenza immunization reduce the risk?

History of infections and vaccinations and risk of lymphoid neoplasms: does influenza immunization reduce the risk?

Social class and risk of Hodgkin's disease in young‐adult women in 1988–94

Seroprevalence of Anti-EBV IgG among Various Age Groups from Khon Kaen Province, Thailand

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