Risk of Hospitalization for Adverse Drug Events in Women and Men: A Post-Hoc Analysis of an Active Pharmacovigilance Study in Italian Emergency Departments

Crescioli, Giada; Boscia, Ennio; Bettiol, Alessandra; Pagani, Silvia; Spada, Giulia; Vighi, Giuditta Violetta; Bonaiuti, Roberto; Venegoni, Mauro; Vighi, Giuseppe; Vannacci, Alfredo; Lombardi, Niccolò

doi:10.20944/preprints202106.0400.v1

Cited by 5 publications

(1 citation statement)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Until there is enduring regulatory intervention regarding the rising prevalence of posthoc expansion of drug indications in CKD patients, there is a need for more robust monitoring and strengthening pharmacovigilance practices amongst Renal and General physicians superintending over the prescribing traffic of these patients. This is vital in the early identification, assessment, and management of these events before irreparable harm ensues (Crescioli et al, 2021).…”

Section: Limited Data On Medication Safety and Efficacymentioning

confidence: 99%

Commentary: Potentially inappropriate medication among older patients with diabetic kidney disease

2023

View full text Add to dashboard Cite

Section: Limited Data On Medication Safety and Efficacymentioning

confidence: 99%

Commentary: Potentially inappropriate medication among older patients with diabetic kidney disease

2023

View full text Add to dashboard Cite

Hospitalisations Related to the Combination of ACE Inhibitors and/or Angiotensin Receptor Blockers with Diuretics and NSAIDs: A Post Hoc Analysis on the Risks Associated with Triple Whammy

et al. 2023

Self Cite

View full text Add to dashboard Cite

This post hoc analysis aimed to assess and characterise adverse events (AEs) related to the triple whammy (i.e., combination therapy of ACE inhibitors, ACE-I, and/or angiotensin receptor blockers, ARBs, with diuretics and non-steroidal anti-inflammatory drugs, NSAIDs) leading to emergency department (ED) visits and/or hospitalisations in the Italian setting. The MEREAFaPS database was analysed. ED visits related to co-treatment with ACE-I and/or ARBs, diuretics, and NSAIDs were considered. Information on the AE (including classification, seriousness, and outcome), suspected and concomitant drugs, and concomitant conditions was retrieved and analysed. Logistic regression was used to estimate the reporting odds ratios (RORs) of hospitalisation associated with the drugs of interest. Between 1 January 2007, and 31 December 2018, 80 patients visited the ED for AEs related to the triple whammy, and a total of 261 suspected drugs were involved. Patients were mostly Caucasian females, with a median age of 85 years, and only 9 of them had renal manifestations. In this subset, drug–drug interaction contributed to kidney injury. Most patients presented a Charlson comorbidity index of 4–5. Overall, 47 patients were hospitalised (58.75%), but no significant differences in the risk of hospitalisation were found according to demographic, clinical, or therapeutic features.

show abstract

Drug-Related Hypersensitivity Reactions Leading to Emergency Department: Original Data and Systematic Review

Pagani

Lombardi

Crescioli

et al. 2022

JCM

View full text Add to dashboard Cite

The aim of the present study is to describe pharmacological characteristics of drug-related allergies and anaphylaxis leading to the emergency department (ED). An 8-year post hoc analysis on the MEREAFaPS Study database was performed (2012–2019). Subjects who experienced drug-related hypersensitivity leading to an ED visit were selected. Logistic regression analyses were used to estimate the reporting odds ratios (RORs) of drug-related allergies and anaphylaxis adjusting for sex, age classes, and ethnicity. In addition, a systematic review of observational studies evaluating drug-related hypersensitivity reactions leading to ED visits in outpatients was performed. Out of 94,073 ED visits, 14.4% cases were drug-related allergies and 0.6% were anaphylaxis. Females accounted for 56%. Multivariate logistic regression showed a higher risk of drug-related allergy among males and all age classes < 65 years, while a higher risk of anaphylaxis was observed for females (ROR 1.20 [1.01–1.42]) and adults (ROR 2.63 [2.21–3.14]). The systematic review included 37 studies. ED visits related to allergy and anaphylaxis ranged from 0.004% to 88%, and drug-related allergies and anaphylaxis ranged from 0.007% to 88%. Both in our analysis and in primary studies, antibacterials, analgesics, and radiocontrast agents were identified as the most common triggers of hypersensitivity.

show abstract

Risk of Hospitalization for Adverse Drug Events in Women and Men: A Post-Hoc Analysis of an Active Pharmacovigilance Study in Italian Emergency Departments

Cited by 5 publications

References 32 publications

Commentary: Potentially inappropriate medication among older patients with diabetic kidney disease

Commentary: Potentially inappropriate medication among older patients with diabetic kidney disease

Hospitalisations Related to the Combination of ACE Inhibitors and/or Angiotensin Receptor Blockers with Diuretics and NSAIDs: A Post Hoc Analysis on the Risks Associated with Triple Whammy

Drug-Related Hypersensitivity Reactions Leading to Emergency Department: Original Data and Systematic Review

Contact Info

Product

Resources

About