Risk of Hyperlipidemia in Women with Hysterectomy-A Retrospective Cohort Study in Taiwan

Li, Pei Chen; Tsai, I‐Ju; Hsu, Chung Y.; Wang, Jen Hung; Lin, Shinn‐Zong; Ding, Dah‐Ching; Sung, Fung Chang

doi:10.1038/s41598-018-31347-z

Cited by 30 publications

(22 citation statements)

References 29 publications

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“…In addition, more than half of female participants with HTG had prior hysterovariectomy (55.2% compared with 19.0% in group 1, Р = 0.018). Similar results were observed in a large retrospective cohort study, where the prevalence of hyperlipidemia was 1.3 times higher after hysterectomy, and 1.9 times higher after hysterovariectomy compared to the control group [15].…”

Section: T a B L E 2 Baseline Lipids And Parameters Of Glucose Regulsupporting

confidence: 88%

Hypertriglyceridemia is associated with long-term risk of cardiovascular events and specific comorbidity in very high-risk hypertensive patients

Korolyuk¹,

Radchenko²

2020

Ukr.Biochem.J.

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although hypertriglyceridemia (hTG) frequently occurs in hypertensive patients and may increase cardiovascular risk, the need for and manner of its reduction remain controversial. The objectives of this study were to compare lipid profiles, parameters of glucose homeostasis, comorbidity, and 5-year survival without cardiovascular events in very high-risk hypertensive (Vhrh) patients with and without hTG, who received moderate intensity atorvastatin therapy. after initial assessment, 107 Vhrh subjects were divided into two groups, i.e., without (n = 49) and with HTG (n = 58). During observation once annually patients were interviewed about prior hospitalizations with further screening for diabetes. combined endpoint included hospitalization due acute myocardial infarction, decompensated heart failure, stroke or death. Survival was analyzed by Kaplan-Meier's method. Nonparametric methods were used for statistical analysis. higher median values of logarithmic value of triglycerides-to-hdl-cholesterol ratio, lipid accumulation product, fasting insulin, and HOMA index were observed in group 2 (P<0.002) that reflect predominance of small dense ldl particles, ectopic lipid deposition and insulin resistance. Patients with hTG more commonly had type 2 diabetes (58.6% vs 34.5%, including first-detected cases during initial assessments and observation, P = 0.02), liver steatosis (81.0% vs 55.1%, P = 0.006), and lithogenic gallbladder disorders (55.2% vs 34.7%, P = 0.05). Women with HTG frequently had a history of hysterovariectomy (55.2% vs 19.0%, Р = 0.018). Despite long-term statin therapy, they often failed to reach recommended ldl-c targets and had worse survival due to significantly higher incidence of combined endpoint (39.6% vs 22.4%, P = 0.027). Further studies are necessary to find safe and effective strategy for secondary prevention in this population. K e y w o r d s: hypertriglyceridemia, very high-risk hypertensive patients, type 2 diabetes, cardiovascular events, atorvastatin therapy.

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Section: T a B L E 2 Baseline Lipids And Parameters Of Glucose Regulsupporting

confidence: 88%

Hypertriglyceridemia is associated with long-term risk of cardiovascular events and specific comorbidity in very high-risk hypertensive patients

Korolyuk¹,

Radchenko²

2020

Ukr.Biochem.J.

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“…Today, surgeons may offer several management options to women with symptomatic POP, including vaginal, abdominal, laparoscopic, and robotic procedures [ 21 ]. Studies have suggested that hysterectomy is associated with hypertension, hyperlipidemia, coronary artery disease, obesity, and lower urinary tract symptoms [ 22 23 24 ]. Furthermore, uterine conservation is crucial for women who wish to preserve their fertility, improve their sexual function, and retain their self-confidence, self-esteem, or the sense of femininity [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

Outcomes of laparoscopic hysteropexy and supracervical hysterectomy plus cervicopexy: A retrospective study

Ding

2020

Tzu Chi Med J

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Objectives: The objective of this study is to compare the outcomes of laparoscopic hysteropexy (LHP) and laparoscopic supracervical hysterectomy plus cervicopexy (LSHCP) for the treatment of pelvic organ prolapse (POP). Materials and Methods: We retrospectively included patients who had undergone laparoscopic sacral hysteropexy or hysterectomy plus cervicopexy between January 2015 and May 2019 at Hualien Tzu Chi Hospital, Taiwan. Age at surgery, body mass index (BMI) at admission, the initial stage of genital prolapse, operative and postoperative data, and anatomical results were recorded. Cure for uterine prolapse was evaluated objectively through vaginal examinations using the POP quantification scale. Visual analog scale (VAS) scores were recorded at 24 h postoperatively. The Mann–Whitney U-test was used to compare continuous variables. Results: A total of 23 women were included in the study; 12 had received LHP ( n = 12) and 11 had received LSHCP ( n = 11). No differences existed in age, parity, BMI, blood loss, or hospital stay between groups. The difference in mean surgical times between the LHP and LSHCP groups was nonsignificant (154 and 176 min, respectively; P = 0.2). VAS scores were significantly lower in the LSHCP group than in the LHP group (0.1 vs. 1.75; P = 0.004). Furthermore, mean hospital stay was significantly longer in the LSHCP group than in the LHP group (4.0 vs. 3.1 days; P = 0.016). The procedure was successful in 100% of patients (23 of 23), with no objective evidence of uterine prolapse on examination at follow-up at 6 months. Conclusion: LHP had a significantly shorter hospital stay and a higher VAS score than LSHCP. LHP and LSHCP are both feasible and effective procedures for correcting uterine prolapse.

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“…The NHI program was established in 1995 with more than 99% of Taiwan's population covered. [ 17 ] The present study used Longitudinal Health Insurance Database 2000 (LHID 2000), with claims data of 1 million patients randomly selected from 23 million insured population in National Health Insurance Research Database (NHIRD). The 1-million database was established by the Bioresource Center at Taiwan's National Health Research Institutes.…”

Section: Methodsmentioning

confidence: 99%

Aspirin associated with a decreased incidence of uterine cancer

Sung

Yang

et al. 2020

Medicine

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Aspirin (ASA) exerts an anti-tumor effect via the COX pathway. Clinical studies on the chemopreventive effects of ASA on uterine cancer (UC) remain inconsistent. We used population-based retrospective cohort study to evaluate the UC in ASA users in Taiwanese women. From insurance claims data, we identified 23,342 women received ASA treatment between 2000 and 2010 and a comparison group of same sample size randomly selected from the same database matched by the propensity score. The incidence of UC in the ASA cohort was 10% of that in the comparison group (0.28 vs 2.73 per 10,000 person-years). The Poisson regression analysis estimated adjusted incidence rate ratio (IRR) was 0.10 (95% confidence interval (CI) = 0.09–0.11) for ASA users relatives to comparisons after controlling for covariates. The UC incidence in ASA users decreased with age, from 0.61 per 10,000 person-years in the 20 to 39 years old (adjusted IRR = 0.21, 95% CI = 0.15–0.29) to 0.21 per 10,000 person-years in the 65 to 80 years old (adjusted IRR = 0.15, 95% CI = 0.12–0.16). The incidence was higher in longer term users. Hormone therapy of estradiol was associated with the increase of UC risk in both cohorts, but less in ASA users than comparisons (1.34 vs 4.75 per 10,000 person-years). This study suggests that ASA use was associated with a decreased risk of UC. Further prospective randomized clinical trials are warranted to confirm the association.

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Risk of Hyperlipidemia in Women with Hysterectomy-A Retrospective Cohort Study in Taiwan

Cited by 30 publications

References 29 publications

Hypertriglyceridemia is associated with long-term risk of cardiovascular events and specific comorbidity in very high-risk hypertensive patients

Hypertriglyceridemia is associated with long-term risk of cardiovascular events and specific comorbidity in very high-risk hypertensive patients

Outcomes of laparoscopic hysteropexy and supracervical hysterectomy plus cervicopexy: A retrospective study

Aspirin associated with a decreased incidence of uterine cancer

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