Risk of infection following colonization with carbapenem-resistant Enterobactericeae: A systematic review

Tischendorf, Jessica S; Avila, Rafael Almeida de; Safdar, Nasia

doi:10.1016/j.ajic.2015.12.005

Cited by 241 publications

(217 citation statements)

References 24 publications

Supporting

Mentioning

177

Contrasting

Unclassified

Order By: Relevance

“…Colonisation with CRE is most often defined by gastrointestinal tract carriage identified through the use of a rectal swab or faecal sampling [31]. Gut microbiota carriage can be identified through clinical culture even when the patient remains asymptomatic.…”

Section: The Role Of Asymptomatic Carriage In Community-associatedmentioning

confidence: 99%

“…Although colonisation is generally a prerequisite for infection, it is largely unknown what percentage of colonised patients will progress to active infection. A recent systematic review pooled 1806 hospital-based patients identified as colonised with CRE at the time of admission and found that 299 (16.5%) progressed to clinical infection [31]. Isolation of hospital patients with known CRE colonisation at the time of admission, whether symptomatic or not, has led to a significant reduction of nosocomial transmission of CRE infection [18].…”

Section: The Role Of Asymptomatic Carriage In Community-associatedmentioning

confidence: 99%

See 1 more Smart Citation

Carbapenem-resistant Enterobacteriaceae in the community: a scoping review

Kelly

Mathema

Larson

2017

International Journal of Antimicrobial Agents

187

141

View full text Add to dashboard Cite

Carbapenem antibiotics are used as a last resort to treat serious Gram-negative bacteria (GNB) infections, however carbapenemase-producing strains of GNB have emerged as a major source of resistance. Owing to the highly transmissible nature of plasmid-borne carbapenemases, numerous reports have warned about the likely spread into the community from healthcare settings. Since the prevalence of carbapenem-resistant Enterobacteriaceae (CRE) in the community is largely unknown, we conducted a scoping review of the literature to assess the percentage of CRE isolates that could be associated with the community. Initially, 361 studies were assessed and 15 met the inclusion criteria. Although 5 studies (33.3%) found no community-associated CRE, the remaining 10 studies identified percentages ranging from 0.04% to 29.5% of either community-associated or community-onset CRE among their samples, with US-based studies alone ranging from 5.6–10.8%. The presence of CRE in the community poses an urgent public health threat.

show abstract

Section: The Role Of Asymptomatic Carriage In Community-associatedmentioning

confidence: 99%

Section: The Role Of Asymptomatic Carriage In Community-associatedmentioning

confidence: 99%

Carbapenem-resistant Enterobacteriaceae in the community: a scoping review

Kelly

Mathema

Larson

2017

International Journal of Antimicrobial Agents

187

141

View full text Add to dashboard Cite

show abstract

“…This data is relatively novel as the most studies of Enterobacteriaceae colonization have focused almost exclusively on gastrointestinal colonization with resistant Enterobacteriaceae. 7 Most Enterobacteriaceae skin colonization occurs in the groin and axilla, and it has been suggested before that the groin may act as a permanent source of Enterobacteriaceae skin colonization in some patients. 8 Both the groin and axilla are rich in sweat glands and this may explain why these sites are most frequently colonized, and why males, with more active sweat glands, are more commonly colonized.…”

Section: Discussionmentioning

confidence: 99%

Antibiotic consumption and Enterobacteriaceae skin colonization in hospitalized adults

Kirby

Berry

West

2017

Journal of Hospital Infection

View full text Add to dashboard Cite

Institution where work was done: University of Leeds SummaryEnterobacteriaceae are increasingly antibiotic resistant and skin colonization with Enterobacteriaceae may contribute to their spread in hospitals. We screened one hundred hospitalised adults for Enterobacteriaceae skin colonization and assessed potential risk factors, including antibiotic consumption. Multivariable analysis identified antibiotic consumption whilst an inpatient (odds ratio 3.16, 95% confidence interval 1.19 to 8.4) and being male (2.92, 1.06-8.4) were risk factors for Enterobacteriaceae skin colonization. These risk factors for Enterobacteriaceae skin colonization require confirmation. If these risk factors are confirmed, work to understand the biological mechanism involved may lead to the development of interventions to prevent Enterobacteriaceae skin colonization.

show abstract

“…Travel history is important for all patients with infections, as knowledge of local pathogens in recent travel destinations may be useful in directing empiric therapy. As an example, travelers to areas endemic for multidrug resistant (MDR) Enterobacteriaceae have an increased risk of acquisition of an MDR Enterobacteriaceae colonizer and patients who are colonized with carbapenem-resistant Enterobacteriaceae (CRE) have a 16.5 % risk of infection with CRE [11]. …”

Section: Epidemiology Of Ssti In the Usa Europe And Worldwidementioning

confidence: 99%

Diagnosis and management of skin and soft tissue infections in the intensive care unit: a review

2016

View full text Add to dashboard Cite

Purpose: To review the salient features of the diagnosis and management of the most common skin and soft tissue infections (SSTI). This review focuses on severe SSTIs that require care in an intensive care unit (ICU), including toxic shock syndrome, myonecrosis/gas gangrene, and necrotizing fasciitis. Methods: Guidelines, expert opinion, and local institutional policies were reviewed. Results: Severe SSTIs are common and their management complex due to regional variation in predominant pathogens and antimicrobial resistance patterns, as well as variations in host immune responses. Unique aspects of care for SSTIs in the ICU are discussed, including the role of prosthetic devices, risk factors for bacteremia, and the need for surgical consultation. SSTI mimetics, the role of dermatologic consultation, and the unique features of SSTIs in immunocompromised hosts are also described. Conclusions: We provide recommendations for clinicians regarding optimal SSTI management in the ICU setting.

show abstract

Risk of infection following colonization with carbapenem-resistant Enterobactericeae: A systematic review

Abstract: Background-Carbapenem-resistant Enterobacteriaceae (CRE) have emerged as important health care-associated pathogens. Colonization precedes infection but the risk of developing infection amongst those colonized with CRE is not clear.

Cited by 241 publications

References 24 publications

Carbapenem-resistant Enterobacteriaceae in the community: a scoping review

Carbapenem-resistant Enterobacteriaceae in the community: a scoping review

Antibiotic consumption and Enterobacteriaceae skin colonization in hospitalized adults

Diagnosis and management of skin and soft tissue infections in the intensive care unit: a review

Contact Info

Product

Resources

About