Risk of intracranial hemorrhage and other adverse outcomes after cocaine exposure in a cohort of 323 very low birth weight infants

Dusick, Anna M.; Covert, Robert F.; Schreiber, Michael D.; Yee, Gloria T.; Browne, Susan P.; Moore, Christine; Tebbett, Ian R.

doi:10.1016/s0022-3476(05)83438-9

Cited by 69 publications

(17 citation statements)

References 34 publications

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“…A small prospective study [9] of very low birth weight (VLBW) babies showed a higher incidence of grade I to II haemorrhage, but not more severe bleeds. A further larger prospective study of VLBW babies [10] did not find any increased risk of grade III or IV intraventricular haemorrhage though it did not consider dosage for confounding or consider smaller bleeds.…”

Section: Discussionmentioning

confidence: 99%

RETRACTED ARTICLE: Multifocal multi-organ ischaemia and infarction in a preterm baby due to maternal intravenous cocaine use: a case report

et al. 2009

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IntroductionAlthough the adverse effects of cocaine use in pregnancy are well recognised, we believe this case highlights the importance of considering the route of administration, and suggests the possibility of multifocal damage relating to intravenous use.Case presentationA Caucasian female baby of 29-weeks' gestation was spontaneously delivered and subsequently developed multi-organ failure considered unrelated to simple prematurity. Intensive care was re-orientated following the development of massive intraventricular haemorrhage.ConclusionThis case illustrates the need for regular cranial ultrasound in babies of pregnancies at risk due to intravenous cocaine use and also the necessity of counselling women who misuse cocaine in the antenatal period. As such, this article will be of most interest to paediatric and obstetric staff.

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Section: Discussionmentioning

confidence: 99%

RETRACTED ARTICLE: Multifocal multi-organ ischaemia and infarction in a preterm baby due to maternal intravenous cocaine use: a case report

et al. 2009

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“…A direct mechanism of cerebral vasoconstriction, independent of delivery complications, is supported by a report by Dominguez et al describing porencephaly and bland infarcts among cocaine-exposed neonates. 68 Early reports of intracranial hemorrhage and cystic lucencies associated with cocaine exposure have been inconsistent: some report no association 69,70 while other report high rates of among cocaineexposed neonates. 71,72 These inconsistencies may be attributable to limitations in identifying most at-risk children with urine toxicology and self-report.…”

Section: Strokesmentioning

confidence: 99%

Fetal Alcohol and Drug Effects

Chiriboga¹

2003

The Neurologist

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Most adverse effects of prenatal drug exposure are self-limited, with catch-up growth and resolution of withdrawal and of prior neurobehavioral abnormalities noted over time. The exception is alcohol, which is linked to life-long impairments (i.e., mental retardation and microcephaly) and possibly cigarette-related behavioral effects. The absence of tangible evidence of detrimental long-term cocaine effects may reflect limitations in the methodology used to identify children at greatest risk for adverse outcome.

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“…Cerebral infarction in the distribution of major brain vessels, usually the middle cerebral artery, has been identified in numerous infants exposed prenatally to cocaine. 13–16 According to clinical and radiographic measures, the time of the infarction varied from hours to months before delivery. Some infants had a well‐established porencephaly, 17 compatible with an event occurring weeks or months earlier, whereas others had cerebral edema indicative of a recent event.…”

Section: Clinical Evidence Of Teratogenic Effects Of Cocaine On the Dmentioning

confidence: 99%

Selective Direct Toxicity of Cocaine on Fetal Mouse Neurons: Teratogenic Implications of Neurite and Apoptotic Neuronal Loss

Nassogne

Evrard²,

Courtoy

1998

Annals of the New York Academy of Sciences

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This chapter reviews epidemiologic clinical surveys and experimental animal studies, indicating that cocaine may induce severe teratogenic effects on the developing brain. Evidence for direct toxic effects is next presented. Using cocultures of embryonic brain cells, we demonstrate that cocaine selectively affects neuronal cells, first causing a dramatic reduction in the number and length of neurites, then extensive neuronal death by apoptosis. By contrast, cocaine affected neither the abundance of astroglial cells nor their glial fibrillary acidic protein content. These effects are not due to cocaine metabolites. The contributions of indirect and direct effects that could account for cocaine neuroteratogenicity are finally discussed.

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Risk of intracranial hemorrhage and other adverse outcomes after cocaine exposure in a cohort of 323 very low birth weight infants

Cited by 69 publications

References 34 publications

RETRACTED ARTICLE: Multifocal multi-organ ischaemia and infarction in a preterm baby due to maternal intravenous cocaine use: a case report

RETRACTED ARTICLE: Multifocal multi-organ ischaemia and infarction in a preterm baby due to maternal intravenous cocaine use: a case report

Fetal Alcohol and Drug Effects

Selective Direct Toxicity of Cocaine on Fetal Mouse Neurons: Teratogenic Implications of Neurite and Apoptotic Neuronal Loss

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