Risk of Iodinated Contrast Material–induced Nephropathy with Intravenous Administration<sup>1</sup>

Katzberg, Richard W.; Barrett, Brendan

doi:10.1148/radiol.2433061411

Cited by 145 publications

(86 citation statements)

References 34 publications

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“…The incidence of CIN has been reported to range from less than 1% to greater than 30%. 13 Iodinated contrast agents are cited as one of the leading causes of acute renal function failure in hospitalized patients. 10,28 It has been suggested that the nephrotoxicity of iodinated contrast agents is a function of dose in relationship to the level of renal function at the time of injection.…”

Section: Discussionmentioning

confidence: 99%

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No Increased Risk for Contrast-Induced Nephropathy after Multiple CT Perfusion Studies of the Brain with a Nonionic, Dimeric, Iso-Osmolal Contrast Medium

Langner¹,

Stumpe²,

Kirsch³

et al. 2008

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE: Contrast-induced nephropathy (CIN) is one of the most common causes of in-hospital acute renal failure. The aim of this study was to assess the risk for CIN after repeated administration of the nonionic, dimeric, iso-osmolal contrast agent iodixanol regardless of pre-existing renal function. Changes in serum creatinine (SCr) levels were compared with those of control subjects who did not receive iodinated contrast media (CM).

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Section: Discussionmentioning

confidence: 99%

“…The route of administration may also contribute to the pathogenesis of CIN. 13 The Nephrotoxic Effects in High-Risk Patients Undergoing Angiography (NEPHRIC) study documented that iso-osmolal CM (IOCM) may have better renal tolerance than low-osmolar CM (LOCM) in high-risk patients undergoing angiography.…”

mentioning

confidence: 99%

No Increased Risk for Contrast-Induced Nephropathy after Multiple CT Perfusion Studies of the Brain with a Nonionic, Dimeric, Iso-Osmolal Contrast Medium

Langner¹,

Stumpe²,

Kirsch³

et al. 2008

AJNR Am J Neuroradiol

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“…Consensus panels [4], recent editorials [5,6] and the 2011 updated ESUR Contrast Media Safety Committee guidelines [7] state that intra-arterial (IA) administration of I-CM appears to pose a greater risk for CIN than intravenous (IV) administration based on the following:…”

Section: Introductionmentioning

confidence: 99%

“…1) The reported frequency of CIN following IV administration of CM has been suggested to be lower than that following cardioangiography and other IA procedures [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Are intravenous injections of contrast media really less nephrotoxic than intra-arterial injections?

et al. 2012

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We oppose the opinion that the intra-arterial administration of iodine-based contrast media (CM) appears to pose a greater risk of contrast medium-induced nephropathy (CIN) than intravenous administration since 1) in intra-arterial coronary procedures and most other intra-arterial angiographic examinations, CM injections are also intravenous relative to the kidneys, 2) there is a lack of comparative trials studying the risk of CIN between intra-arterial and intravenous procedures with matched risk factors and CM doses, 3) a bias selection of patients with fewer risk factors may explain the seemingly lower rate of CIN after CT in comparison with coronary interventions, 4) the rate of CIN following intra-arterial coronary procedures may also be exaggerated owing to other causes of acute kidney failure, such as haemodynamic instability and microembolisation, 5) roughly the same gramiodine/GFR ratio (≈1:1) as a limit of relatively safe CM doses has preliminarily been found for both intravenous CT and intra-arterial coronary procedures and 6) the substantially higher injected intravenous CM dose rate during CT relative to an intra-arterial coronary procedure might actually pose a higher risk of CIN following CT. Key Points• Most intra-arterial injections of contrast media are intravenous relative to the kidneys.• No evidence that intravenous CM injections should be less nephrotoxic than intra-arterial.• Considerably higher dose rates of CM are used for CT relative to intra-arterial procedures. • Higher dose rates may pose higher nephrotoxic risk for intravenous based CT studies.

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“…Computed Tomography (CT) can be used to study the limbic system although to a lesser extent; besides, its grey-white matter dissociation is not has high as in MRI while it delivers ionizing radiation, to be avoided if possible, due to its biological effects. Extra consideration should be given to the administration of iodinated contrast material to enhance grey matter on CT since it has deleterious effects over the kidneys (Klatzberg and Barrett 2007). Neuro imaging techniques to demonstrate the amygdala morphologically are therefore mainly and almost exclusively based on magnetic resonance imaging (MRI), capable of rendering a detailed neurostructural analysis, and also to assess neural connectivity, in vivo biochemical properties and functionality at a synchronous moment without moving the studied subject from the same imaging modality unit in which the exam is being performed.…”

Section: Figure 1 Paradigm Shift In Brain Imagingmentioning

confidence: 99%

Neuroimaging of the Amygdala: Quantitative Mechanistic Approach

Bertoni¹

2012

The Amygdala - A Discrete Multitasking Manager

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Risk of Iodinated Contrast Material–induced Nephropathy with Intravenous Administration¹

Cited by 145 publications

References 34 publications

No Increased Risk for Contrast-Induced Nephropathy after Multiple CT Perfusion Studies of the Brain with a Nonionic, Dimeric, Iso-Osmolal Contrast Medium

No Increased Risk for Contrast-Induced Nephropathy after Multiple CT Perfusion Studies of the Brain with a Nonionic, Dimeric, Iso-Osmolal Contrast Medium

Are intravenous injections of contrast media really less nephrotoxic than intra-arterial injections?

Neuroimaging of the Amygdala: Quantitative Mechanistic Approach

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Risk of Iodinated Contrast Material–induced Nephropathy with Intravenous Administration1

Cited by 145 publications

References 34 publications

No Increased Risk for Contrast-Induced Nephropathy after Multiple CT Perfusion Studies of the Brain with a Nonionic, Dimeric, Iso-Osmolal Contrast Medium

No Increased Risk for Contrast-Induced Nephropathy after Multiple CT Perfusion Studies of the Brain with a Nonionic, Dimeric, Iso-Osmolal Contrast Medium

Are intravenous injections of contrast media really less nephrotoxic than intra-arterial injections?

Neuroimaging of the Amygdala: Quantitative Mechanistic Approach

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Product

Resources

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Risk of Iodinated Contrast Material–induced Nephropathy with Intravenous Administration¹