Risk of Kaposi Sarcoma after Solid-Organ Transplantation: Multicenter Study in 4767 Recipients in Italy, 1970–2006

Piselli, Pierluca; Busnach, G; Citterio, Franco; Frigerio, Maria; Arbustini, Eloisa; Burra, Patrizia; Pinna, A.D.; Bresàdola, Vittorio; Ettorre, Giuseppe Maria; Baccarani, Umberto; Buda, Andrea; Lauro, Augusto; Zanus, Giacomo; Cimaglia, Claudia; Spagnoletti, Gionata; Lenardon, A.; Agozzino, Manuela; Gambato, Martina; Zanfi, Chiara; Miglioresi, L.; Gioia, P. Di; Mei, Luigina; Ippolito, Giuseppe; Serraino, Diego

doi:10.1016/j.transproceed.2009.03.009

Cited by 42 publications

(43 citation statements)

References 7 publications

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“…[5][6][7][8][9] As skin cancer is the most prevalent tumor in the organ transplant recipient setting, one would expect that viruses may contribute to this well-documented increased susceptibility and incidence. The discovery and detection of b-HPV-DNA and its active infection in epidermodysplasia verruciformis patients provided an important new insight into the viral oncogenesis of skin cancer that might be extendable to other subsets of patients including other primary immunodeficiencies and particularly long-lasting iatrogenically immunosuppressed patients, such as organ transplant recipients.…”

Section: Modern Pathology (2014) 27 1101-1115mentioning

confidence: 99%

“…[1][2][3][4] Most of these cancers are caused by reactivated viruses whose oncogenic potential is suppressed by immunological reactions in healthy individuals, like Epstein-Barr virus-associated B-cell lymphomas, Kaposi's sarcoma, caused by the reactivation of human herpesvirus type 8, and Merkel cell carcinoma of the skin, associated with Merkel cell polyomavirus. [5][6][7][8][9] Of the cancers presenting in organ transplant recipients that have no established infectious etiology, skin cancer is the most frequent form (95%), including squamous and basal cell carcinomas. [10][11][12][13] The incidence of skin cancer, the most common cancer in fair-skinned populations, is at least 50-fold higher in organ transplant recipients.…”

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Improved detection reveals active β-papillomavirus infection in skin lesions from kidney transplant recipients

et al. 2014

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The aim of this study was to determine whether detection of b-HPV gene products, as defined in epidermodysplasia verruciformis skin cancer, could also be observed in lesions from kidney transplant recipients alongside the viral DNA. A total of 111 samples, corresponding to 79 skin lesions abscised from 17 kidney transplant recipients, have been analyzed. The initial PCR analysis demonstrated that b-HPV-DNA was highly present in our tumor series (85%). Using a combination of antibodies raised against the E4 and L1 proteins of the b-genotypes, we were able to visualize productive infection in 4 out of 19 actinic keratoses, and in the pathological borders of 1 out of 14 squamous cell carcinomas and 1 out of 31 basal cell carcinomas. Increased expression of the cellular proliferation marker minichromosome maintenance protein 7 (MCM7), that extended into the upper epithelial layers, was a common feature of all the E4-positive areas, indicating that cells were driven into the cell cycle in areas of productive viral infections. Although the present study does not directly demonstrate a causal role of these viruses, the detection of E4 and L1 positivity in actinic keratosis and the adjacent pathological epithelium of skin cancer, clearly shows that b-HPV are actively replicating in the intraepidermal precursor lesions of kidney transplant recipients and can therefore cooperate with other carcinogenic agents, such as UVB, favoring skin cancer promotion. Modern Pathology (2014) 27, 1101-1115; doi:10.1038/modpathol.2013.240; published online 3 January 2014Keywords: b-HPV; immunosuppression; kidney transplant recipients; skin cancer; viral life cycle Solid organ transplantation is a treatment offered to an increasing number of patients with end-stage organ diseases. Although lifesaving, organ transplantation is associated with an overall three-to fivefold increased risk of malignancies. 1-4 Most of these cancers are caused by reactivated viruses whose oncogenic potential is suppressed by immunological reactions in healthy individuals, like Epstein-Barr virus-associated B-cell lymphomas, Kaposi's sarcoma, caused by the reactivation of human herpesvirus type 8, and Merkel cell carcinoma of the skin, associated with Merkel cell polyomavirus. [5][6][7][8][9] Of the cancers presenting in organ transplant recipients that have no established infectious etiology, skin cancer is the most frequent form (95%), including squamous and basal cell carcinomas. [10][11][12][13] The incidence of skin cancer, the most common cancer in fair-skinned populations, is at least 50-fold higher in organ transplant recipients. 14-16 Large numbers of skin tumors (often more than 10) tend to develop over time in these at-risk subjects, thus

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Section: Modern Pathology (2014) 27 1101-1115mentioning

confidence: 99%

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confidence: 99%

Improved detection reveals active β-papillomavirus infection in skin lesions from kidney transplant recipients

et al. 2014

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“…En un estudio poblacional italiano, el período postrasplante temprano fue un factor de riesgo de aparición de SK en receptores de órganos sólidos, en comparación con la población general. 2 Algunos reportes mencionan una alta mortalidad 3,4 y otros describen buenas evoluciones de esta complicación con la conversión del tratamiento inmunosupresor a sirolimus, debido a sus propiedades antiproliferativas y antitumorales. [5][6][7] Informamos sobre un caso de SK en un receptor pediátrico que se presentó 4 meses postrasplante hepático y mostró buena evolución con suspensión del tacrolimus y conversión a sirolimus como tratamiento inmunosupresor.…”

Section: Discussionunclassified

“…1,13 El SK por HHV-8 se observó en receptores de órganos sólidos y con mayor riesgo en la población italiana. 2 Aseni y cols., informaron una prevalencia de 1% para SK en receptores adultos de trasplante hepático con alta mortalidad (4 de 5 pacientes murieron por esta complicación).…”

Section: Discussionunclassified

Sarcoma de Kaposi por virus del herpes humano de tipo 8 en un receptor de trasplante hepático pediátrico. Caso clínico

Malla¹,

Perez²,

Cheang³

et al. 2013

Arch Argent Pediat

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Arch Argent Pediatr 2013;111(5):e125-e128 / e125Presentación de casos clínicos RESUMEN Los pacientes que reciben tratamiento inmunosupresor están en riesgo de desarrollar tumores malignos. La infección primaria o reactivación del virus del herpes humano de tipo 8 (HHV-8) puede predisponer al sarcoma de Kaposi después del trasplante de un órgano sólido. En los receptores de trasplantes pediátricos, este sarcoma tiene baja incidencia y mal pronóstico. Se informa la presentación clínica de un sarcoma de Kaposi en un ganglio linfático luego de una infección por HHV-8 en un niño a los 4 meses del trasplante hepático. El paciente tuvo buena evolución con suspensión del tacrolimus y conversión a sirolimus un mes después del diagnóstico. En nuestro conocimiento, este es el primer caso de sarcoma de Kaposi en un receptor pediátrico de trasplante hepático informado en nuestro país y creemos que esta entidad debería considerarse como diagnóstico diferencial en las complicaciones postrasplante. Palabras clave: trasplante hepático, pediatría, virus del herpes humano de tipo 8, malignidad, sarcoma de Kaposi.

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“…Most of the lesions reported appear on the skin, but there have been reports of Kaposi sarcoma after a solid organ transplant occurring in other locations. 1 Two cases of Kaposi sarcoma originating from the transplant ureter after a kidney transplant have been reported. 2,3 However, to the best of our knowledge, none has been reported in the native ureter.…”

Section: Introductionmentioning

confidence: 99%

Kaposi Sarcoma of the Ureter After Liver Transplant: Case Report and Literature Review

Chen

Zhao

Qiu³

et al. 2012

Exp Clin Transplant

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Kaposi sarcoma after an organ transplant is rare and infrequently involves internal organs. There are 2 reported cases in the English literature of Kaposi sarcoma originating from the transplant ureter after kidney transplant. We report a case of Kaposi sarcoma that occurred in the native ureter of the liver transplant recipient. Initially, the patient refused any further investigation and management and 2 years subsequent, had to undergo a left radical nephroureterectomy owing to the loss of renal function and distending pain. He recovered very well and no recurrence was detected at 47 months' follow-up. To our knowledge, it is the first report in English. We review the literature on this topic and explore the therapeutic principles and histologic features of this sarcoma.

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Risk of Kaposi Sarcoma after Solid-Organ Transplantation: Multicenter Study in 4767 Recipients in Italy, 1970–2006

Cited by 42 publications

References 7 publications

Improved detection reveals active β-papillomavirus infection in skin lesions from kidney transplant recipients

Improved detection reveals active β-papillomavirus infection in skin lesions from kidney transplant recipients

Sarcoma de Kaposi por virus del herpes humano de tipo 8 en un receptor de trasplante hepático pediátrico. Caso clínico

Kaposi Sarcoma of the Ureter After Liver Transplant: Case Report and Literature Review

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