Risk of leukaemia among pesticide manufacturing workers: A review and meta-analysis of cohort studies

Pesticide exposure in farming and forestry and the risk of uveal melanoma

“…The only statistically significant risk increase that we observed was with exposure to chemical fertilizers in 13), but this result was based on only three exposed case and three exposed control subjects ( Table 3). Analyses of exposure scores taking into account pesticide handling and mode of application as well as use of personal protective equipment did not indicate elevated risks.…”

“…Although epidemiological evidence points toward an association with respect to various cancer types, such as leukemia, lymphoma, brain cancer, lung, and kidney cancer, overall results regarding their carcinogenicity are inconsistent [1,[11][12][13]. Hormone-sensitive cancers such as testicular, prostate, ovarian or breast cancer have also been inconsistently associated with exposure to pesticides [1,11,[14][15][16].…”

Gender-linked haematopoietic and metabolic disturbances induced by a pesticide mixture administered at low dose to mice

“…Nevertheless, in a recent meta-analysis, we showed a significant relationship between professional exposure to pesticides and the risk of developing haematopoietic malignancies, particularly non-Hodgkin's lymphoma (NHL) (Merhi et al, 2007). Moreover, Van Maele-Fabry et al (2008) also confirmed this correlation for myeloid leukaemia. In AML (acute myeloid leukaemia) patients professionally exposed to pesticides or organic solvents, the clinico-biologic characteristics are similar to the features of AML arising in patients with prior chemotherapy for another tumour, thus suggesting that similar transformation pathways may underlie leukemogenesis induced by cytotoxic drugs and by environmental exposure to certain pesticides or organic solvents Fagioli et al, 1992).…”

Increased cancer burden among pesticide applicators and others due to pesticide exposure

“…145 A recent metaanalysis of 13 cases and controls examining the association between occupational exposures and hematopoietic cancers observed an OR of 1.35 (95% CI, 0.9-2.0).…”