Risk of lung, larynx, pharynx and buccal cavity cancers among carbon electrode manufacturing workers.

Jj, Moulin; Wild, Pascal; Jm, Mur; Lafontaine, Marie‐France; Lefer, M; M, Mercier-Gallay; Villemot, P; Whebi,; Jp, Coulon

doi:10.5271/sjweh.1885

Cited by 22 publications

(17 citation statements)

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“…4 Nor did we find increased mortality for cancers of the oral cavity and pharynx. Overall, mortality from cancers related to tobacco was in line with regional rates, suggesting that the prevalence of smoking in the cohort was similar to, or lower than in the general population.…”

Section: Discussionmentioning

confidence: 69%

Mortality from cancer and chronic respiratory diseases among workers who manufacture carbon electrodes

Donato

Monarca²,

Marchionna³

et al. 2000

Occup Environ Med

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Objectives-To investigate the risk of cancer and non-neoplastic respiratory diseases among workers who manufacture carbon electrodes, as this industry entails exposure to mixtures of polycyclic aromatic hydrocarbons. Methods-A historical cohort study was carried out of 1006 male workers employed for at least 1 year between 1945 and 1971 in a carbon (graphite) electrode production plant in central Italy, who were followed up for mortality between 1955 and 1996. The ratio of observed to expected deaths (standardised mortality ratios, SMRs) was computed from both national and (for the period 1964-96) regional age and period specific mortalities. A multivariate Poisson regression analysis was performed to investigate the relative risk (RR) of death according to duration of employment and time since first employment in the factory. Results-A total of 424 workers had died, 538 were still alive, and 44 were lost to follow up. Mortalities from all causes, all cancers, and respiratory tract cancer were in line with the regional figure. An excess was found over the expected deaths from skin cancer including melanoma (SMR 3.16, 95% confidence interval (95% CI) 0.65 to 9.23) and from non-neoplastic respiratory diseases (SMR 1.58, 95% CI 1.16 to 2.11). Poisson regression analysis including age as a covariate showed an increased risk of dying from gastric cancer with increasing duration of employment, and an increase in the RR of dying from lung cancer and from nonneoplastic respiratory diseases with increasing time since first employment, although the linear trend was not significant. Conclusion-This study supports previous findings that working in the carbon electrode manufacturing industry may not increase the risk of dying from respiratory cancer. However, a possible association with non-malignant respiratory diseases cannot be excluded. (Occup Environ Med 2000;57:484-487)

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Section: Discussionmentioning

confidence: 69%

Mortality from cancer and chronic respiratory diseases among workers who manufacture carbon electrodes

Donato

Monarca²,

Marchionna³

et al. 2000

Occup Environ Med

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“…These five men who had died from respiratory cancers had smoked cigarettes, had been hired after 1934 and had worked at that location for at least 25 years; however, these data are insufficient to confirm that exposure to asbestos and tobacco were involved in the etiology of their death. Moulin et al (1989) reported the findings of an epidemiological study of two carbon electrode manufacturing plants in France. In plant A (which produced graphite electrodes), all male workers employed at the beginning of 1975 were followed for cancer incidence in 1975-85.…”

Section: 17mentioning

confidence: 99%

“…A meta-analysis on occupational exposures and pancreatic cancer (Ojajärvi et al, 2000) identified four informative studies of occupational exposures to PAH compounds (Cammarano et al, 1986;Moulin et al, 1989;Siemiatycki, 1991;Kauppinen et al, 1995). The meta-risk ratio for pancreatic cancer associated with exposure to PAHs was 1.5 (95% CI, 0.9-2.5).…”

Section: (B) Urinary Bladder Cancermentioning

confidence: 99%

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Integrating Field Analyses with Laboratory Exposures to Assess Ecosystems Health

Hellou¹,

Beach²,

Leonard³

et al. 2012

Polycyclic Aromatic Compounds

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initiated a programme on the evaluation of the carcinogenic risk of chemicals to humans involving the production of critically evaluated monographs on individual chemicals. The programme was subsequently expanded to include evaluations of carcinogenic risks associated with exposures to complex mixtures, life-style factors and biological and physical agents, as well as those in specific occupations. The objective of the programme is to elaborate and publish in the form of monographs critical reviews of data on carcinogenicity for agents to which humans are known to be exposed and on specific exposure situations; to evaluate these data in terms of human risk with the help of international working groups of experts in chemical carcinogenesis Publications of the World Health Organization enjoy copyright protection in accordance with the provisions of Protocol 2 of the Universal Copyright Convention. All rights reserved.The International Agency for Research on Cancer welcomes requests for permission to reproduce or translate its publications, in part or in full. Requests for permission to reproduce or translate IARC publications -whether for sale or for noncommercial distribution -should be addressed to WHO Press, at the above address (fax: +41 22 791 4806; email: permissions@who.int).The designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of the Secretariat of the World Health Organization concerning the legal status of any country, territory, city, or area or of its authorities, or concerning the delimitation of its frontiers or boundaries.The mention of specific companies or of certain manufacturers' products does not imply that they are endorsed or recommended by the World Health Organization in preference to others of a similar nature that are not mentioned. Errors and omissions excepted, the names of proprietary products are distinguished by initial capital letters.The IARC Monographs Working Group alone is responsible for the views expressed in this publication. IARC Library Cataloguing in Publication Data NOTE TO THE READERThe term 'carcinogenic risk' in the IARC Monographs series is taken to mean that an agent is capable of causing cancer under some circumstances. The Monographs evaluate cancer hazards, despite the historical presence of the word 'risks' in the title.Inclusion of an agent in the Monographs does not imply that it is a carcinogen, only that the published data have been examined. Equally, the fact that an agent has not yet been evaluated in a Monograph does not mean that it is not carcinogenic.The evaluations of carcinogenic risk are made by international working groups of independent scientists and are qualitative in nature. No recommendation is given for regulation or legislation.Anyone who is aware of published data that may alter the evaluation of the carcinogenic risk of an agent to humans is encouraged to make this information available to the Section of IARC Monographs, International Agency for...

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“…B. Kehlkopfkarzinome, möglich, wobei die überzeugende Argumentation hier schwieriger sein dürfte. Literaturhinweise zum Zusammenhang mit polyzyklischen aromatischen Kohlenwasserstoffen: [3,4,5,20,100,105,126,132,153,163,172,173,174].…”

Section: 32unclassified

Gutachterliche Probleme bei Berufskrankheiten durch Inhalationsnoxen

Deitmer

2004

Laryngorhinootologie

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Gutachten für die gesetzliche Unfallversicherung Der Hauptanteil gutachterlicher Anforderungen an Hals-Nasen-Ohrenärzte zur Frage beruflicher Krebserkrankungen bei Inhalationsnoxen bezieht sich auf den Rechtsbereich der gesetzlichen Unfallversicherungen und wird somit im Wesentlichen von gewerblichen Berufsgenossenschaften angefordert. Diesem Zusammenfassung Das Referat gibt eine detaillierte Einführung in das deutsche Berufskrankheitenrecht unter dem Aspekt der Begutachtung von Malignomen im HNO-Bereich. Die wichtigen versicherungsrechtlichen Betrachtungen werden behandelt. Neben anerkannten Zusammenhängen, wie z. B. dem Adenokarzinom der Nase bei Holzstaubexposition und dem Larynxkarzinom bei hoher Asbestfaserstaubbelastung, werden auch Expositions/Erkankungs-Konstellationen diskutiert, für die derzeit die versicherungsrechtliche Bewertung strittig ist. Ein ausführlicher Verweis auf Literaturstellen ist in das Referat eingearbeitet. Eine sinnvolle Strukturierung eines solchen Gutachtens wird vorgeschlagen. Gutachten für den Bereich des Schwerbehindertengesetzes und Rentenversicherungsträger werden ebenfalls behandelt.

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Risk of lung, larynx, pharynx and buccal cavity cancers among carbon electrode manufacturing workers.

Cited by 22 publications

References 14 publications

Mortality from cancer and chronic respiratory diseases among workers who manufacture carbon electrodes

Mortality from cancer and chronic respiratory diseases among workers who manufacture carbon electrodes

Integrating Field Analyses with Laboratory Exposures to Assess Ecosystems Health

Gutachterliche Probleme bei Berufskrankheiten durch Inhalationsnoxen

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