Risk of major adverse events associated with gabapentinoid and opioid combination therapy: A systematic review and meta-analysis

Hahn, Jae Won; Jo, Youn Yi; Yoo, So-Young; Shin, Jaekyu; Yu, Yun Mi; Ah, Young‐Mi

doi:10.3389/fphar.2022.1009950

Cited by 14 publications

(10 citation statements)

References 72 publications

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“…In 2022, Hahn et al. ( 72 ) found that opioid-gabapentin combination therapy, despite reducing gastrointestinal adverse effects, may also lead to an increased risk of central nervous system depression and death. A recent meta-analysis ( 73 ) compared the efficacy of combinations of two or more drugs with placebo or at least one monotherapy in adults with NP.…”

Section: Discussionmentioning

confidence: 99%

“…Combining different medications can sometimes improve analgesia and/or tolerability (71), but the increased use of combination medications also poses some safety concerns. In 2022, Hahn et al (72) found that opioid-gabapentin TABLE 6 The common pathophysiological characteristics between neuropathic pain and Multiple sclerosis, Alzheimer's disease, Parkinson's disease and Huntington's disease.…”

Section: Treatment Of Npmentioning

confidence: 99%

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Research trends and hotspots of neuropathic pain in neurodegenerative diseases: a bibliometric analysis

Gong

Zhu

et al. 2023

Front. Immunol.

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BackgroundNeuropathic pain is caused by a neurological injury or disease and can have a significant impact on people’s daily lives. Studies have shown that neuropathic pain is commonly associated with neurodegenerative diseases. In recent years, there has been a lot of literature on the relationship between neuropathic pain and neurodegenerative diseases. However, bibliometrics is rarely used in analyzing the general aspects of studies on neuropathic pain in neurodegenerative diseases.MethodsThe bibliometric analysis software CiteSpace and VOSviewer were used to analyze the knowledge graph of 387 studies in the Science Citation Index Expanded of the Web of Science Core Collection Database.ResultsWe obtained 2,036 documents through the search, leaving 387 documents after culling. 387 documents were used for the data analysis. The data analysis showed that 330 papers related to neuropathic pain in neurodegenerative diseases were published from 2007–2022, accounting for 85.27% of all published literature. In terms of contributions to the scientific study of neuropathic pain, the United States is in the top tier, with the highest number of publications, citations, and H-indexes.ConclusionThe findings in our study may provide researchers with useful information about research trends, frontiers, and cooperative institutions. Multiple sclerosis, Parkinson’s disease, and Alzheimer’s disease are the three most studied neurodegenerative diseases. Among the pathological basis of neurodegenerative diseases, microglia-regulated neuroinflammation is a hot research topic. Deep brain stimulation and gamma knife radiosurgery are two popular treatments.

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Section: Discussionmentioning

confidence: 99%

Section: Treatment Of Npmentioning

confidence: 99%

Research trends and hotspots of neuropathic pain in neurodegenerative diseases: a bibliometric analysis

Gong

Zhu

et al. 2023

Front. Immunol.

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“…The post-intervention SMD was calculated from the depression score after vitamin D supplementation between the intervention and placebo groups. Heterogeneity was assessed using Cochrane’s Q and I 2 statistics, with significance set at p > 0.1 and I 2 > 50% ( 33 ). A fixed-effects model was used in the absence of significant heterogeneity, and a random-effects model was used in the presence of significant heterogeneity ( 34 ).…”

Section: Methodsmentioning

confidence: 99%

Vitamin D supplementation for depression in older adults: a meta-analysis of randomized controlled trials

Park

2023

Front. Nutr.

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BackgroundIn older adults, depression is associated with several other clinical problems such as cognitive impairment and low quality of life. Several studies have evaluated the relationship between vitamin D and depression in older adults; however, the results have been controversial thus far.ObjectiveThis study aimed to investigate the effects of vitamin D supplementation on depressive symptom improvement among individuals aged ≥60 years with or without a diagnosis of depression or depressive symptoms based on a meta-analysis of randomized controlled trials (RCTs).MethodsRCTs were identified to analyze the relationship between vitamin D supplementation and depressive symptoms. MEDLINE, CENTRAL, Embase, and PsycINFO were systematically searched for relevant articles published from inception to November 2022. RCTs that evaluated the effect of vitamin D supplementation in participants aged ≥60 years compared to placebo were included. A random effects model was used in this meta-analysis because of the differences between the included RCTs. The quality of the RCTs was assessed using Risk of Bias 2.ResultsSeven trials were included in the analyses. The primary outcome of pre-post score changes included five trials with a total of 752 participants. The secondary outcome of post-intervention score included all seven trials with a total of 4,385 participants. No significant improvement in depressive symptoms in either pre-post score changes [standardized mean difference (SMD) = −0.49; 95% confidence interval (CI) −1.07–0.09; p = 0.10] or post-intervention score (SMD = −0.10; 95% CI −0.28–0.07; p = 0.25) was found.ConclusionVitamin D supplementation in older adults was not associated with an improvement in depressive symptoms. More studies in older adults are needed to evaluate the association between vitamin D supplementation and depression.

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“…Adverse effects of SNRIs include nausea, headache, dizziness, sweating, and arterial hypertension. Patients on gabapentinoids frequently complain of dizziness or somnolence, but both pregabalin and gabapentin are also associated with more serious adverse events, such as respiratory depression [56] and abuse [57].…”

Section: The Problem Of Neuropathic Feature In Cancer Painmentioning

confidence: 99%

Cancer Pain Management - Current Concepts, Strategies and Management Techniques

Mestdagh¹,

Steyaert²,

Lavand’homme³

2023

Preprint

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Pain is frequently reported during cancer disease, and still remains poorly controlled in 40% of patients. Recent developments in oncology have helped to better control pain. Targeted treatments may cure cancer disease and significantly increase survival. Thereby, a novel population of patients (cancer survivors) has emerged, also enduring chronic pain (27.6% moderate to severe pain). The present review discuss the different options currently available to manage pain in (former) cancer patients in the light of progress made in the last decade. Major progress in the field are recent development of a chronic cancer pain taxonomy now included in International Classification of Diseases (ICD-11) and update of WHO analgesic ladder. Until recently, cancer pain management has mostly relied on pharmacotherapy, opioids being considered as mainstay. The opioids crisis has prompted the reassessment of opioids use, both in cancer patients and cancer survivors. The review focuses on the current utilization of opioids, on the neuropathic pain component often neglected and on techniques and non-pharmacological strategies available which help to personalize patient’s treatment. Cancer pain management is now closer to the management of chronic non-cancer pain i.e. “an integrative pain care” aiming to improve patient’s quality of life.

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Risk of major adverse events associated with gabapentinoid and opioid combination therapy: A systematic review and meta-analysis

Cited by 14 publications

References 72 publications

Research trends and hotspots of neuropathic pain in neurodegenerative diseases: a bibliometric analysis

Research trends and hotspots of neuropathic pain in neurodegenerative diseases: a bibliometric analysis

Vitamin D supplementation for depression in older adults: a meta-analysis of randomized controlled trials

Cancer Pain Management - Current Concepts, Strategies and Management Techniques

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