Risk of Malignancy in Patients With Follicular Neoplasm

Gülçelik, Neşe Ersöz; Gülçelik, Mehmet Ali; Kuru, Bekir

doi:10.1001/archotol.134.12.1312

Cited by 64 publications

(16 citation statements)

References 23 publications

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“…Similarly, in a long term study from Boston, Yassa et al found no difference in cancer rates in nodules between 1cm and greater than 3cm 31 . Similar results have been produced from other parts of the world 32,33 . A study from Seoul looking at sub cm nodules actually found a higher rate of malignancy in the smaller nodules 34 .…”

Section: Sizesupporting

confidence: 86%

“…Of the six commonly reported ultrasound signs of malignancy, Ultrasound reports of multinodular goitres usually reported on dominant nodules implying the largest nodule. However recent research suggests that size is not a factor in predicting malignancy 31,32,33 and thus the most ultra-sonographically suspicious nodule and not the largest should be identified for biopsy. In the work done by Papini 30 , the efficiency of using malignant ultrasound features to target biopsy in multinodular goitres resulted in the diagnosis of 21.7% of malignant nodules as opposed to only 5.8% when using size alone.…”

Section: Discussionmentioning

confidence: 99%

“…In fact, many authors looking at newer ultrasound features only review solid nodules and exclude cystic lesions altogether 32,33 . In an older paper from 2001, Koike et al from Japan showed that 81.8% of all malignant nodules were completely solid 37 and in 2007, a Korean study of 1036 patients demonstrated that 98.4% of papillary cancers and 82.6% of follicular cancers were solid 38 .…”

Section: 1solid/cysticmentioning

confidence: 99%

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Pre-operative diagnosis of thyroid cancer: Clinical, radiological and pathological correlation

Cairncross¹,

Panieri²

2013

S Afr J Surg

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Section: Sizesupporting

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Section: 1solid/cysticmentioning

confidence: 99%

See 1 more Smart Citation

Pre-operative diagnosis of thyroid cancer: Clinical, radiological and pathological correlation

Cairncross¹,

Panieri²

2013

S Afr J Surg

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“…Many authors reported that the size of follicular neoplasms increases the risk of malignancy [5, 18, 20–22, 24–26, 28, 31–36, 42]. Tuttle et al [26] reported that the risk of carcinoma in a tumor larger than 4 cm was 40%, while in smaller tumors it was only 13%.…”

Section: Discussionmentioning

confidence: 99%

Preoperative serum thyroglobulin concentration as a predictive factor of malignancy in small follicular and Hürthle cell neoplasms of the thyroid gland

2014

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BackgroundCytologic examination of a fine-needle aspiration biopsy specimen cannot distinguish between benign and malignant follicular or Hürthle cell neoplasms. Serum thyroglobulin (Tg) concentrations are higher in follicular and Hürthle cell carcinomas than in benign follicular or Hürthle cell tumors, but preoperative measurement of Tg is not recommended for initial evaluation of thyroid nodules. The aim of this study was to find out whether preoperative serum Tg concentration is a predictive factor of malignant disease in patients with a follicular or Hürthle cell neoplasm with a diameter of 2 cm or less.MethodsFrom 1988 to 2013, a total of 244 patients (214 female, 30 male, age range 9 to 82 years, median age 52 years) had a surgical procedure at our institute because of follicular or Hürthle cell neoplasms with a tumor diameter of 2 cm or less. In these patients a preoperative concentration of Tg was determined and Tg-autoantibodies were negative. The risk factors for malignancy were identified by a chi-square test and multivariate logistic regression.ResultsThe histopathologic diagnoses were carcinoma, adenoma, and benign goiter in 62 (25.5%), 115 (47%), and 67 (27.5%) patients, respectively. The median preoperative Tg concentration in benign tumors, papillary carcinomas, follicular carcinomas, and Hürthle cell carcinomas was 41, 87, 72, and 106 ng/ml (P = 0.05), respectively. The predictive factors for carcinoma shown by the chi-square test were: sex, thyroid volume, and preoperative Tg concentration. The independent predictors of malignancy as shown by multivariate logistic regression were: male sex (odds ratio, 2.57; P = 0.02), and a Tg concentration of more than 80 ng/ml (odds ratio, 2.35; P = 0.005).ConclusionThe independent predictors of malignancy in follicular or Hürthle cell neoplasms are sex and preoperative Tg concentration.

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“…8 However, if FNA is done on time when necessary, it can prevent unnecessary surgeries. 12 Therefore, in these cases it can be valuable to be familiar with malignancy features in FNA and sonography.…”

Section: Introductionmentioning

confidence: 99%

To differentiate benign from malignant thyroid nodule comparison of sonography with FNAC findings

Rahimi¹,

Farshchian²,

Rezaee³

et al. 2012

Pak J Med Sci

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Objectives: To evaluate the diagnostic accuracy of sonography and Fine Needle Aspiration Cytology (FNAC). Methodology: This follow-up study was approved by review board and conducted at Endocrine Clinic and Radiology Department of Imam Reza, Kermanshah. The patients were diagnosed to have thyroid nodule examined by FNA and Sonography suspicious malignant cases underwent surgery. Results were entered in SPSS 11.5 chi-Square and Fisher exact test applied to compare malignant and benign nodule characters. Results: In this study 144 patients were examined and 14 cases (9.7%) had malignant nodule. Most of malignant nodules were single (p=0.001), solid (p < 0.001), hypo-echo (p=0.001), with irregular margins (p < 0.001) and with calcification (p=0.041). There was no significant relationship between malignancy and nodule size of larger than 15 mm (p=0.395). Compared with surgery, FNA sensitivity and specificity were calculated as 92.8% and 100% respectively. Conclusion: Based on the result of this study, thyroid nodule size must not be considered as a criterion for malignancy and thyroid nodules of any size must be suspected as malignant. Important criteria for malignancy include irregular edges, being solid, hypoechogenicity and being a single nodule respectively. Compared with Surgery, FNA Sensitivity and specificity were calculated as 92.8% and 100% respectively.

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Risk of Malignancy in Patients With Follicular Neoplasm

Cited by 64 publications

References 23 publications

Pre-operative diagnosis of thyroid cancer: Clinical, radiological and pathological correlation

Pre-operative diagnosis of thyroid cancer: Clinical, radiological and pathological correlation

Preoperative serum thyroglobulin concentration as a predictive factor of malignancy in small follicular and Hürthle cell neoplasms of the thyroid gland

To differentiate benign from malignant thyroid nodule comparison of sonography with FNAC findings

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