Risk of malignant change in ulcerative colitis.

Hinton, John

doi:10.1136/gut.7.5.427

Cited by 123 publications

(41 citation statements)

References 22 publications

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“…3) [55], Similar findings of an equally good prognosis in ulcerative colitis colorectal can cer and noncolitic large bowel cancers, espe cially when matched for stage, have been recently reported by several authors [56,[61][62][63][64], The 5-year survival rate of both colorec tal cancer in ulcerative colitis and de novo rectal cancer has been shown to range from 31 to 50% overall [52. 56, 61] with a 66% survival rate for curable cases as compared with 69% in noncolitic patients [56].…”

Section: Prognosissupporting

confidence: 55%

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Cancer in Inflammatory Bowel Disease

Greenstein

Sachar

1983

Dig Dis

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Section: Prognosissupporting

confidence: 55%

“…Most of the earlier series reporting a gloomy prognosis [55] were in fluenced by a large proportion of advanced cancers. Ohman [56], in a study carried out over a 30-year period (1950-1979), found a higher proportion of Duke's C lesions in ulcer ative colitis cancer than in noncolitic colorec tal cancer.…”

Section: Cancer Detection and Preventionmentioning

confidence: 99%

Cancer in Inflammatory Bowel Disease

Greenstein

Sachar

1983

Dig Dis

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“…We note that carcinoma of the colon behaves differently when it supervenes on ulcerative colitis; it is more undifferentiated (Hinton, 1966), appears in multiple sites in up to 42 % of patients (Kronman, 1971), occurs at an earlier age of life (Brooke, 1969), and is located more often in clinically 'silent' areas in the ascending and transverse colon (Counsell and Dukes, 1952). Furthermore the risk of carcinoma is markedly increased in ulcerative colitis (Burdette, 1971), and its prognosis is poor with a five-year survival rate of 19 to 32% (Brooke, 1969).…”

Section: Discussionmentioning

confidence: 77%

Studies of carcinoembryonic antigen of whole and extracted serum in ulcerative colitis

Khoo¹,

Hunt²,

Mackay³

1973

Gut

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SUMMARY The present study has used a microradioimmunoassay to detect carcinoembryonic antigen(s) (CEA) in whole and extracted serum in 77 patients with ulcerative colitis, two of whom had coexisting colonic carcinoma, and 69 patients with carcinoma of the colon or rectum. Taking 5 ng/ml as the level of positivity, the CEA assay on whole serum showed positive results in patients with 'active' ulcerative colitis (15 of 17) but not in those with 'inactive' disease (0 of 23). In two patients, levels fell during drug-induced remission. Our results also indicated that a positive result for CEA on extracted serum was associated with carcinomatous changes in ulcerative colitis in contrast to uncomplicated ulcerative colitis in which positive results were obtained only with whole serum.

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“…1 This risk begins to increase approximately 10 years after the onset of the disease and increases with the extent and duration of the inflammatory process. 2,3 The current standard practical strategy manifest instability in more advanced lesions. 18 Furthermore, Willenbucher et al 19 reported that ten microsatellite markers were totally negative in the nondysplastic mucosa of UC patients.…”

Section: Introductionmentioning

confidence: 99%

Microsatellite instability and loss of heterozygosity in the nondysplastic colonic epithelium of ulcerative colitis

Takahashi

Kojima

Kinouchi

et al. 2003

Journal of Gastroenterology

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Background. A major longterm risk for patients with ulcerative colitis (UC) is the development of colorectal dysplasia and cancer. Microsatellite instability (MI) has now been reported not only in colitic cancers but also in dysplasias, and even in nondysplastic inflamed mucosa. With the conventional microdissection technique, however, contamination by nonepithelial cells cannot be prevented and this could produce less reliable results than other methods. Therefore, we examined the condition of MI and loss of heterozygosity (LOH) of UC epithelium using a crypt isolation technique. Methods. One hundred and twenty-nine biopsy samples from 21 patients with UC were investigated for histology and microsatellite status, using nine microsatellite markers. A total of 1031 polymenase chain reaction (PCR) products were evaluated. Results. We found that no microsatellite markers displayed instability, but LOH at the 3p locus was detected in the nondysplastic epithelium of one patient with longstanding UC. Conclusions. Our study strongly suggests that MI does not contribute to the progression of the colitis-dysplasia sequence.

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Risk of malignant change in ulcerative colitis.

Cited by 123 publications

References 22 publications

Cancer in Inflammatory Bowel Disease

Cancer in Inflammatory Bowel Disease

Studies of carcinoembryonic antigen of whole and extracted serum in ulcerative colitis

Microsatellite instability and loss of heterozygosity in the nondysplastic colonic epithelium of ulcerative colitis

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