1966
DOI: 10.1152/ajplegacy.1966.210.5.1015
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Risk of mortality in interrupted exposure to 100 percent O-2: role of air vs. lowered Po2

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Cited by 20 publications
(4 citation statements)
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“…Interruption midway through a 16-hour total exposure markedly increased the survival of T. tubijex. Interrupting oxygen exposures with an interval in air has also been reported to benefit dogs (Paine et al, 1941), rats (Barach, Eckman, Oppenheimer, Rumsey and Soroka, 1944;Ackerman and Brinkley, 1966), guinea pigs (Penrod, 1956), mice (Wright, Weiss, Hiatt and Rustagi, 1966), rabbits (Ackerman and Brinkley, 1966) and Drosophila (Fenn, Henning and Philpott, 1967a;Fenn, Philpott, Meehan and Henning, 1967b). Recovery from eight-hour, half-lethal oxygen doses in T. tubijex is rapid being half maximal in four hours and maximal in approximately 16 hours.…”
Section: Discussion*mentioning
confidence: 99%
“…Interruption midway through a 16-hour total exposure markedly increased the survival of T. tubijex. Interrupting oxygen exposures with an interval in air has also been reported to benefit dogs (Paine et al, 1941), rats (Barach, Eckman, Oppenheimer, Rumsey and Soroka, 1944;Ackerman and Brinkley, 1966), guinea pigs (Penrod, 1956), mice (Wright, Weiss, Hiatt and Rustagi, 1966), rabbits (Ackerman and Brinkley, 1966) and Drosophila (Fenn, Henning and Philpott, 1967a;Fenn, Philpott, Meehan and Henning, 1967b). Recovery from eight-hour, half-lethal oxygen doses in T. tubijex is rapid being half maximal in four hours and maximal in approximately 16 hours.…”
Section: Discussion*mentioning
confidence: 99%
“…We evaluated the time course of iNOS expression by reverse transcriptase/polymerase chain reaction (RT-PCR) in lung homogenates from mice breathing air or Ͼ 98% O 2 for 6, 24, 48, and 72 h. For all other studies, we examined the response to Ͼ 98% O 2 for 72 h because this exposure is known to cause pulmonary edema and an inflammatory cell infiltrate (14,15) and because this fell short of the time reported for 50% survival (4 to 6 d) at this concentration (9)(10)(11)(12)(13). In an initial study we confirmed a survival time of 135 Ϯ 3.6 h (mean Ϯ standard error of the mean [SEM]) for wild-type mice exposed to Ͼ 98% O 2 ( n ϭ 24).…”
Section: General Protocolmentioning
confidence: 99%
“…The objective of this study was to determine whether the iNOS isoform protects against acute continuous exposure to 100% oxygen in a well-described in vivo model of lung injury (10)(11)(12)(13). Prolonged exposure to this oxygen tension typically induces pulmonary edema and an inflammatory cell infiltrate (14,15).…”
mentioning
confidence: 99%
“…Rapid regression of the effects of oxygen toxicity was noted in the short period out of oxygen at atmospheric pressure, and obviously recovery is just as possible in the absence of inert gas. 236 Although it has been shown that rat brain tissue is slowly poisoned by 100 per cent oxygen at 1 atmosphere,75 nO' definite clinical evidence of such toxicity has been shown at 1 atmosphere. '…”
Section: Hedley-whyte and Wintermentioning
confidence: 99%