Risk of multiple primary tumors following oral squamous‐cell carcinoma

Abstract

The follow-up of 727 patients with squamous-cell carcinoma (SCC) of the lip and oral cavity has been used for the risk analysis of multiple primary tumors (MPTs) following SCC of the lip and oral cavity. Age-, gender- and site-specific cancer-incidence rates from the general population have been applied to the appropriate persons-years of follow-up of patients with SCC of the lip and oral cavity. The study indicates that patients with a primary SCC of the lip and oral cavity have, compared with the general population, a significantly elevated risk of developing an additional cancer of the oral cavity and/or pharynx, the risk being 74.7-fold for males and 190.4-fold for females. Furthermore, a 24.6 and 45.3 times higher risk of an additional esophageal tumor was found in males and females respectively. The risk of cancer of the lung and pharynx was less elevated compared with the risk of cancer of the upper digestive tract. No elevated risks were established in organs outside the respiratory and upper digestive tract.

Multiple primary cancer: an experience at the Cancer Institute Hospital with special reference to colorectal cancer

“…A high risk of developing second cancers in patients with oropharyngeal, laryngeal, or esophageal cancer has also been reported elsewhere. [5][6][7] It should also be remembered that 5.8% of patients with urogenital cancer developed cancers in other organs. It is therefore essential to remember that cancer patients have an increased risk of developing second cancers in various sites, either synchronously or metachronously.…”

“…The frequent association between colorectal cancer and gastric cancer, for example, suggests a need to pay attention to gastric cancer when treating colorectal cancer. 6 At CIH, all patients with colorectal cancer currently undergo screening upper gastrointestinal endoscopy before operation. In addition, we recommend repeated upper gastrointestinal endoscopy at 2-year intervals during the first 5 years after operation.…”

Effects of 1,4-phenylenebis(methylene)selenocyanate on mutagenesis and p53 protein expression in the tongue of lacI rats treated with 4-nitroquinoline-N-oxide

“…Oral cancer progresses from hyperplastic lesions, through dysplasia and carcinoma in situ to invasive carcinoma [9][10][11]. Patients with oral cancers have an increased incidence of second primary tumors of the oral cavity [12] [13]. Although patients with early lesions have a high cure rate of their primary tumors; continued exposure to carcinogenic insult (e.g.…”

STAT signaling in head and neck cancer

“…aerodigestive tumors) formation each year following initial treatment (Jovanovich et al, 1994). The probability of a second malignancy arising within 5 years after the initial tumor presentation can reach 22% (Dhooge et al, 1998).…”