Risk of obstructive sleep apnoea in patients with rheumatoid arthritis: a nationwide population-based retrospective cohort study

Abstract

ObjectiveSleep disorders are prevalent medical disorders in patients with rheumatoid arthritis (RA). However, whether patients with RA are at an increased risk of developing obstructive sleep apnoea (OSA) is unclear.DesignUsing population-based retrospective cohort study to examine the risk of OSA in patients with RA.SettingWe used claims data of the National Health Insurance Research Database (NHIRD) of Taiwan.ParticipantsWe identified a RA cohort with 33 418 patients newly diagnosed in 2000–2010 and a randomly selected non-RA comparison cohort with 33 418 individuals frequency matched by sex, age and diagnosis year.Primary and secondary outcome measuresIncident OSA was estimated by the end of 2011. The HRs of OSA were calculated using the Cox proportional hazards regression analysis.ResultsThe overall incidence rate of OSA was 75% greater in the RA cohort than in the non-RA cohort (3.04 vs 1.73/10 000 person-years, p<0.001), with an adjusted HR (aHR) of 1.75 (95% CI 1.18 to 2.60). Stratified analyses by sex, age group and comorbidity revealed that the incidence rates of OSA associated with RA were higher in all subgroups.ConclusionsThis population-based retrospective cohort study suggested that patients with RA should be monitored for the risk of developing OSA.

Chronic rhinosinusitis and premorbid autoimmune diseases: a population-based case–control study

“…The primary interests of the study were the presence of autoimmune diseases, including ankylosing spondylitis (ICD-9-CM 720.0), Behçet’s disease (ICD-9-CM 136.1), dermatomyositis (ICD-9-CM 710.3), multiple sclerosis (ICD-9-CM 340), polymyositis (ICD-9-CM 710.4), psoriasis (ICD-9-CM 696.0, 696.1), rheumatoid arthritis (ICD-9-CM 714.0), sicca syndrome (ICD-9-CM 710.2), systemic lupus erythematosus (ICD-9-CM 710.0), and systemic sclerosis (ICD-9-CM 710.1) 16 , 17 . In addition, we evaluated the presence of several comorbidities to investigate their relation to CRS.…”

Fatigue, Sleep, and Autoimmune and Related Disorders

“…The comorbidity of autoimmune disease and sleep disorders is documented for a small number of autoimmune diseases, although this area of research is widely under investigated. Rheumatoid arthritis, ankylosing spondylitis, systemic lupus erythematosus, Sjörgen's syndrome, pemphigus, and systemic sclerosis are associated with increased occurrence of sleep apnea (174, 187, 188). Multiple sclerosis is associated with an increased risk of rapid-eye movement (REM) sleep behavior disorder (189).…”

Rheumatologische Erkrankungen und Schlaf – Schlafmedizinische Aspekte der Diagnostik und Therapie – Eine literaturbasierte Übersicht

“…In den vergleichbaren Kohorten (77,6 % Frauen) zeigte sich, dass bei OSAS-Patienten mit RA die Diagnose Schlafapnoe zu einem früheren Zeitpunkt der Erkrankung gestellt wird. Nach Adjustierung für Alter, Geschlecht und Komorbiditäten berechnet sich ein 1,7-mal höheres Risiko für RA-Patienten, an OSAS zu erkranken [72]. Daher sollte die rheumatologische Diagnostik durch validierte Fragebögen zur Selbstbeurteilung des Patienten ergänzt werden, die eine hohe Prätestwahrscheinlichkeit für ein positives apparatives Untersuchungsergebnis ergeben.…”