Risk of oral cancer associated with gutka and other tobacco products: A hospital-based case-control study

Mahapatra, Sandeep; Kamath, Ramachandra; Shetty, Bharatesh K.; Binu, V S

doi:10.4103/0973-1482.143332

Cited by 36 publications

(23 citation statements)

References 11 publications

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“…Additionally, smokeless tobacco is established as an independent risk factor for oral cancer; an increased risk of oral cancer has been identified with use of numerous tobacco products, including gutka, supari (areca nut) and betel quid (Piper betle), with an odds ratio between 5.1 and 11.4 (44).…”

Section: Oscc and Opscc Carcinogenesismentioning

confidence: 99%

Epigenetics of oral and oropharyngeal cancers (Review)

et al. 2018

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Oral and oropharyngeal cancers represent the two most common malignancies of the head and neck region. The major risk factors for these cancers include alcohol consumption, tobacco use (via smoking or chewing) and high-risk human papillomavirus infection. The transition from normal epithelium to premalignant tissue and finally carcinoma is in part caused by a summation of genetic and epigenetic modifications. Epigenetic refers to modifications in the way the genome is expressed in cells. The most common examples of epigenetic control of gene expression are DNA methylation, histone modification and regulation by small non-coding RNAs. The aim of the current paper was to review the recent studies on the main epigenetic changes that have been suggested to serve a role in the carcinogenesis process and progression of oral and oropharyngeal cancers. Furthermore, it is discussed how the epigenetic changes may be used as potential predictive biomarkers and how recent findings in the field may impact the personalized cancer therapy approach for these tumors.

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Section: Oscc and Opscc Carcinogenesismentioning

confidence: 99%

Epigenetics of oral and oropharyngeal cancers (Review)

et al. 2018

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“…Dietary factors may play a role, together with genetic predisposition, because not all smokers or alcoholics get cancer, and not all patients with cancer have such habits [32,33]. Other factors are associated with the ability to metabolize carcinogens or repair DNA.…”

Section: Discussionmentioning

confidence: 99%

TC2 C776G polymorphism studies in patients with oral cancer in the Polish population

Malinowska

Morawiec-Sztandera

Majsterek

et al. 2016

pjp

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The first signs of oral cancer may resemble developing infections in the mucous membranes, with throat cancer symptoms being similar to those of upper respiratory tract infections. This greatly hinders rapid diagnosis and treatment. Better knowledge of the changes occurring in the metabolism of folic acid can help in understanding the carcinogenesis affecting DNA methylation and genome stability. Polymorphisms in genes encoding enzymes involved in this pathway may influence enzyme activity and thereby interfere with the concentrations of homocysteine and S-adenosylmethionine, which are important for DNA synthesis and cellular methylation reactions. The aim of the study was to determine the risk of oral cancer associated with the TC2 C776G polymorphism, as determined in 119 patients. Genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The test genotype was found to correspond to the Hardy-Weinberg (HW) equilibrium (p > 0.05). In our population G/G homozygosity of C776G TC2 gene polymorphism increases the risk of oral cancer; OR (odds ratio): 4.3875; 95% CI (confidence interval): 2.0518-9.319; p = 0.001. Regarding C/G genotype of the C776G TC2 gene, polymorphism also increases the risk of developing this cancer; OR 2.4146 95% CI: 1.2803-4.5541; p = 0.01.

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“…Additional tobacco products that are used primarily in Eastern LMICs include bidis, supari, betel quid, gutka, and pan masala (Mahapatra et al, 2015). These products present unique challenges for tobacco control.…”

Section: Recent and Ongoing Challenges And Opportunities In Globalmentioning

confidence: 99%

“…Use of any of these alternative tobacco products conveys increased risk for NCDs, including CVD (Mahapatra et al, 2015; Maziak, 2012; Rahman and Fukui, 2000; Rastogi et al, 2005). Despite known health consequences, these products are not yet consistently regulated.…”

Section: Recent and Ongoing Challenges And Opportunities In Globalmentioning

confidence: 99%

Global tobacco prevention and control in relation to a cardiovascular health promotion and disease prevention framework: A narrative review

Carroll

Huffman

Hitsman

2016

Preventive Medicine

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The purpose of this review is to emphasize the role of tobacco prevention and control in cardiovascular health (CVH) promotion and cardiovascular disease (CVD) prevention, including the importance of these endpoints for measuring the full impact of tobacco-related policies, programs, and practices. In this review, we describe an overview of tobacco control interventions that have led to substantial declines in tobacco use and the relationship between these declines with CVH and CVD. We review interventions that have had success in high-income countries (HICs) as well as those that are gaining traction in low- and middle-income countries (LMICs). We emphasize the challenges to comprehensive tobacco prevention and control strategies faced by LMICs, and highlight the special role of cardiovascular health professionals in achieving CVH promotion and CVD prevention endpoints through tobacco control. Tobacco prevention and control strategies have a strong scientific basis, yet a distinct gap remains between this evidence and implementation of tobacco control policies, particularly in LMICs. Health professionals can contribute to tobacco control efforts, especially through patient-level clinical interventions, when supported by a health care system and government that recognize and support tobacco control as a critical strategy for CVH promotion and CVD prevention. Understanding, supporting, and applying current and evolving policies, programs, and practices in tobacco prevention and control is the province of all health professionals, especially those concerned with CVH promotion and CVD prevention. A new tobacco control roadmap from the World Heart Federation provides a strong impetus to the needed interdisciplinary collaboration.

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Risk of oral cancer associated with gutka and other tobacco products: A hospital-based case-control study

Abstract: The study provided strong evidence that gutka, supari, chewing tobacco, betel quid, bidi and alcohol are independent risk factors for oral cancer.

Cited by 36 publications

References 11 publications

Epigenetics of oral and oropharyngeal cancers (Review)

Epigenetics of oral and oropharyngeal cancers (Review)

TC2 C776G polymorphism studies in patients with oral cancer in the Polish population

Global tobacco prevention and control in relation to a cardiovascular health promotion and disease prevention framework: A narrative review

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