Risk of osteoarthritis in patients with hidradenitis suppurativa: a global federated health network analysis

Abstract

BackgroundOsteoarthritis and hidradenitis suppurativa (HS) share a common inflammatory pathway. However, whether patients with HS have higher risk developing osteoarthritis remained unclear.MethodsA retrospective cohort design was adopted in this study. Electronic medical records had been retrieved from the US collaborative network in the TriNetX research network. A propensity score matching of 1:1 was performed to match for covariates. In total, 50,931 patients with HS and the same amount of non-HS controls were identified for analyses. Hazard ratio (HR) of osteoarthritis in patient with HS was calculated.ResultsRisk of patients with HS developing osteoarthritis was 1.37-fold higher than that of non-HS controls [95% confidence interval (CI), 1.21–1.55] when followed up for 1 year. The significance remained when the follow-up periods were extended to 3 years and 5 years. When osteoarthritis was stratified on occurring sites, the HR of knee osteoarthritis was 1.19 (95% CI, 1.09–1.29) and the HR of hip osteoarthritis was 1.17 (95% CI, 1.01–1.35) in the 5-year follow-up. The 5-year risk of osteoarthritis remained significant in sensitivity models.ConclusionPatients with HS were of high risk of developing osteoarthritis compared with people without HS. The clinical association was recommended to be considered while approaching patients with HS.

Increased Risk of New-Onset Rheumatoid Arthritis Among Osteoarthritis Patients Received Total Knee Arthroplasty: a global federated health network analysis

“…This subset retrieved the health data from 60 HCOs in the United States, and contained greater than 80 million patients' data. This subset of TriNetX was widely applied in epidemiological studies in various fields of clinical investigation [33][34][35] .…”

Risk of Keratitis and Keratopathy in Hidradenitis Suppurativa Patients: A Global Federated Health Network Analysis

“…We utilized data from the TriNetX research network, a global federated health network that aggregates electronic health records from over 100 collaborative healthcare organizations (HCOs) worldwide. TriNetX is a widely utilized platform in epidemiological and clinical dermatology research (24,25). The records within the TriNetX database undergo a comprehensive de-identification process, negating the requirement for informed consent in studies utilizing this database.…”

New-Onset Hidradenitis Suppurativa in Psoriasis Patients: A Multi-Center, Retrospective Cohort Study

“…While its prevalence estimates range from 0.7% to 1.2%, with a higher predisposition among females [ 8 ], HS persists as a significant medical concern due to its substantial impact on patients’ quality of life and the considerable healthcare costs associated with its management [ 9 ]. HS comorbidities have been documented to affect multiple organ systems [ 10 , 11 , 12 , 13 ]. Although the precise pathogenesis of HS remains unknown, there is a consensus that it is a multifactorial disease involving immunological factors and the recruitment of self-perpetuating inflammatory mediators [ 14 ].…”