Risk of osteoporosis in patients with erectile dysfunction

Abstract

Background: Erectile dysfunction (ED) and osteoporosis are both common health problems and have similar risk factors. Recent studies have found that people with ED have a higher risk of osteoporosis. We aimed to systematically assess osteoporosis risk in patients with ED. Methods: A systematically research was carried out in Medline via PubMed, Cochrane Library, EMBASE, and Web of Science up to June 4, 2020, to identify articles related to ED and osteoporosis. The 2 researchers independently reviewed the literature, extracted the data, and evaluated the quality of the literature. All analyses were done using RevMan5.3 and Stata14. Results: A total of 4 studies involving 22,312 participants were included. The meta-analysis results showed that the risk of osteoporosis in the ED group was significantly higher than that in the non-ED group [odds ratio (OR) = 2.66, 95% confidence interval (95% CI) 1.42 to 4.98, P = .002, I 2 = 68%]. Interestingly, compared with older participants, the increased risk of osteoporosis in ED patients seemed to be more pronounced in younger participants. Despite the lack of data for meta-analysis, more than half of the literature mentioned this tendency. We found the source of heterogeneity through sensitivity analysis, and there was no significant effect on the results before and after the removal of this literature, indicating that our results were robust. No obvious publication bias was found through Egger method ( P = .672). Conclusion: People with ED have a higher risk of osteoporosis, especially among younger males. Because the assessment of osteoporosis is economical and noninvasive, ED patients should be evaluated by bone mineral density or men with osteoporosis should be further assessed for erectile function.

Downregulation of inflammatory erectile dysfunction by Mantisa religiosa egg-cake through NO-cGMP-PKG dependent NF-kB signaling cascade activated by mixture of salt intake

“…However, the protein-rich-cake (10%PMEC) by a factor of 4 (25%) pharmacologically inhibited the arginase activity to restore erectile function [39] . The decline in arginase activity in the present study may also be attributed to increased bio-availability of NO in the penile vascular cells [40] . It is very imperative to report here that protein-rich-cake (10%PMEC) that contain flavonoids, carotenoids and phenols may retard arginase activity.…”

Is erectile dysfunction associated with osteoarthritis and rheumatoid arthritis? Insights from a population-based study

“…According to Deniz et al, 19 patients with sarcopenia had an almost 30% higher chance of having moderate to severe ED compared to those without (70.8% vs 42.1%， P < .001). In a rigorous meta-analysis, Xu et al 20 meticulously dissected data from a substantial participant pool comprising 22 312 individuals, revealing that patients with ED had a higher risk of osteoporosis than patients without ED (odds ratio [OR], 2.66; 95% CI, 1.42-4.98; P = .002). In a separate investigation, Wilton et al 21 employed a comprehensive population-based cohort approach to delve into potential interplays between various health conditions.…”