Risk of Parkinson’s disease in multiple sclerosis and neuromyelitis optica spectrum disorder: a nationwide cohort study in South Korea

Kwon, Soonwook; Jung, Sung Il; Han, Kyungdo; Jung, Jae-Hun; Yeo, Yohwan; Cho, Eun Bin; Ahn, Jong Hyeon; Shin, Dong Wook; Min, Ju Hong

doi:10.1136/jnnp-2022-329389

Cited by 11 publications

(5 citation statements)

References 43 publications

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“…The primary outcome of the study was newly diagnosed PD, which was identified by both ICD-19 code (G20) and registration code (V124) of the Rare Intractable Disease management program in Korea, as in prior studies [26][27][28]. Patients diagnosed with PD were identified with code V124, which is specified by criteria comparable to the UK Parkinson's Disease Society Brain Bank Diagnostic Criteria [29], and the diagnosis is confirmed by a neurologist or neurosurgeon.…”

Section: Study Outcome and Follow-upmentioning

confidence: 99%

Risk of Parkinson disease in stroke patients: A nationwide cohort study in South Korea

Choi,

Ahn,

Chang

et al. 2024

Euro J of Neurology

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Background and purposePrevious studies have examined the risk of stroke in patients with Parkinson disease (PD), but the incidence of PD onset among stroke patients and its risk according to severity of poststroke disabilities have scarcely been investigated. This study aims to determine whether the risk of PD is increased among stroke patients using a retrospective cohort with a large population‐based database.MethodsWe used data collected by the Korean National Health Insurance Service from 2010 to 2018 and examined 307,361 stroke patients and 380,917 sex‐ and age‐matched individuals without stroke to uncover the incidence of PD. Cox proportional hazards regression was used to calculate the hazard ratio (HR) and 95% confidence interval (CI), and the risk of PD was compared according to presence and severity of disability.ResultsDuring 4.31 years of follow‐up, stroke patients had a 1.67 times higher risk of PD compared to individuals without stroke (adjusted HR = 1.67, 95% CI = 1.57–1.78). The risk of PD was greater among stroke patients with disabilities than among those without disabilities, even after adjustment for multiple covariates (adjusted HR = 1.72, 95% CI = 1.55–1.91; and adjusted HR = 1.66, 95% CI = 1.56–1.77, respectively).ConclusionsOur study demonstrated an increased risk of PD among stroke patients. Health professionals need to pay careful attention to detecting movement disorders as clues for diagnosing PD.

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Section: Study Outcome and Follow-upmentioning

confidence: 99%

Risk of Parkinson disease in stroke patients: A nationwide cohort study in South Korea

Choi,

Ahn,

Chang

et al. 2024

Euro J of Neurology

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“…This study was conducted as a retrospective matched cohort study from March 2022 to April 2023. 15 MS and NMOSD were defined as in a previous study in Korea and used the same database: [16][17][18] both ICD-10 diagnosis codes and information from the Rare Intractable Disease (RID) management program in South Korea, which has been operated since 2009, were used. Patients registered in the RID pay 10% of their total medical expenses out-of-pocket instead of the usual 20%-60% of total medical expenses.…”

Section: Definitions Of Ms/nmosd and Matched Controlsmentioning

confidence: 99%

“…MS and NMOSD patients met the following criteria: (1) ⩾2 outpatient or hospitalization claims with the relevant ICD-10 code (G35.0 for MS and G36.0 for NMOSD) and ( 2) registration in the RID system with the code (V022 for MS and V276 for NMOSD). 17 The index year for MS and NMOSD patients was designated as the year of the first claim for each case.…”

Section: Definitions Of Ms/nmosd and Matched Controlsmentioning

confidence: 99%

Risk of depression and anxiety in multiple sclerosis and neuromyelitis optica spectrum disorder: A nationwide cohort study in South Korea

Kwon,

Han,

Jung

et al. 2024

Mult Scler

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Background: We investigated the risks of depression/anxiety in patients with multiple sclerosis (pwMS) or patients with neuromyelitis optica spectrum disorder (pwNMOSD). Objectives: MS/NMOSD cohorts were collected from Korean National Health Insurance Service, using the International Classification of Diseases-10th and information on Rare Intractable Disease program. Patients who were younger than 20 years, had a previous depression/anxiety, or died in the index year were excluded. Methods: Hazard ratios (HRs) of depression/anxiety in pwMS and pwNMOSD from controls matched 1:5 for age, sex, hypertension, diabetes, and dyslipidemia were calculated using Cox regressions with a 1-year lag period and estimated over time. Results: During a mean follow-up of 4.1 years, adjusted hazard ratios (aHR) for depression were 3.25 (95% confidence interval (CI) = 2.59–4.07) in MS and 2.17 (1.70–2.76) in NMOSD, and aHRs for anxiety were 1.83 (1.49–2.23) in MS and 1.56 (1.26–1.91) in NMOSD. The risks of anxiety/depression did not differ between MS and NMOSD and were highest in the second year after diagnosis of MS/NMOSD. The relative risk of depression was higher in younger pwMS/pwNMOSD, and the relative risk of anxiety was higher in pwMS who was male, had low income, or lived in a non-urban area. Conclusion: The risk of depression and anxiety was increased in pwMS/pwNMOSD.

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“…The RID program provides a copayment reduction of up to 10% for various rare and intractable diseases including ALS. 10 To be registered in the RID program, a diagnosis certification submitted by a neurologist is required based on the Awaji criteria or revised El Escorial criteria. A total of 2,252 ALS patients were identified according to the following criteria (Figure 1): (i) ≥2 outpatient or hospitalization claims with the ICD-10 code G12.21 for ALS and (ii) registration in the RID with code V123 for ALS.…”

Section: Study Participantsmentioning

confidence: 99%

Increased Risk of Ischemic Stroke in Amyotrophic Lateral Sclerosis: A Nationwide Cohort Study in South Korea

Kwon

Kim

Han

et al. 2023

Preprint

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Background: We investigated the risk of ischemic stroke in ALS and analyzed the effect of ALS-related physical disability using the Korean National Health Insurance Service database. Methods: A total of 2,252 ALS patients diagnosed between January 1, 2012, and December 31, 2015, and 1:10 age- and sex-matched control populations were included. After selection of cases that participated in the national health check-up programs, 659 ALS patients and 10,927 non-ALS participants were remained. Newly developing ischemic stroke as primary outcome was also defined by the ICD code and the incidence probability was assessed using by the Kaplan–Meier method during the follow-up duration. A Cox hazard regression model was used to examine the hazard ratios (HRs) for ischemic stroke in ALS after adjusting for potential confounders. Results: ALS patients were younger than the control group (60.3 ± 10.2 years vs. 61.4 ± 10.5 years, p = 0.008), and the proportion of male patients was similar between the two groups (61.0% vs. 62.5%, p = 0.447). ALS patients were more likely to have a lower body mass index (23.1 ± 2.92 vs. 24.0 ± 3.00, p < 0.001) and be non-drinkers (64.2% vs. 57.4%, p = 0.002) than the controls. In ALS patients, the incidence of ischemic stroke was 7.8 per 1,000 person-years, and the adjusted HR of ischemic stroke was 3.67 (95% confidence interval 2.02–6.67) compared with the control group. The risk of ischemic stroke did not differ by the presence of disability in ALS patients. Conclusions: Our findings suggest that ALS patients face increased risk of ischemic stroke compared with controls, but the risk did not differ by the presence of disability in ALS.

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Risk of Parkinson’s disease in multiple sclerosis and neuromyelitis optica spectrum disorder: a nationwide cohort study in South Korea

Cited by 11 publications

References 43 publications

Risk of Parkinson disease in stroke patients: A nationwide cohort study in South Korea

Risk of Parkinson disease in stroke patients: A nationwide cohort study in South Korea

Risk of depression and anxiety in multiple sclerosis and neuromyelitis optica spectrum disorder: A nationwide cohort study in South Korea

Increased Risk of Ischemic Stroke in Amyotrophic Lateral Sclerosis: A Nationwide Cohort Study in South Korea

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