Risk of Peripheral Arterial Occlusive Disease in Patients With Systemic Lupus Erythematosus

Chuang, Ya‐Wen; Yu, Mei‐Ching; Lin, Cheng‐Li; Yu, Tung‐Min; Shu, Kuo‐Hsiung; Kao, Chia‐Hung

doi:10.1097/md.0000000000002121

Cited by 29 publications

(28 citation statements)

References 35 publications

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“…5 Indeed, in a previous study in our SLE cohort, age was the only independent predictor of PAD 6. In a nationwide population-based cohort study in Taiwan, younger (≤34 years) patients with SLE were at a higher risk of symptomatic PAD 7. In a Swedish population-based study, an increased risk of myocardial infarction and stroke was demonstrated among female patients with SLE compared with the general population.…”

Section: Introductionmentioning

confidence: 65%

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Predictors of peripheral arterial disease in SLE change with patient’s age

et al. 2017

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ObjectiveTo analyse the differential influence of risk factors of peripheral artery disease (PAD) according to age in patients with SLE.Methods216 patients from the Lupus-Cruces cohort were divided in three age groups: ≤34 years, 35–49 years and ≥50 years. A low ankle–brachial index defined PAD. Significant variables were identified by univariant and multivariant analysis in each age group.ResultsDifferent factors were identified in different age groups: antiphospholipid antibodies/antiphospholipid syndrome and glucocorticoids in patients ≤34 years; in patients 35–49 years old, hypertension was the only statistically significant predictor, although a trend was observed for fibrinogen levels; a trend was observed for hypercholesterolaemia in those ≥50 years.ConclusionsAge may modulate the influence of risk factors for PAD in patients with SLE.

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Section: Introductionmentioning

confidence: 65%

“…Patients were divided in three groups according to age at the time of the ABI, as proposed by Chuang et al :7 ≤34 years (group 1), 35–49 years (group 2) and ≥50 years (group 3).…”

Section: Methodsmentioning

confidence: 99%

Predictors of peripheral arterial disease in SLE change with patient’s age

et al. 2017

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“…The risk of peripheral artery occlusive disease (PAOD) is also high and has been reported to be ninefold higher than the general population, and higher in the first year after diagnosis; afterward it tends to decline ( 20 ). As in myocardial infarction and ischemic stroke, the relative risk was particularly higher in younger women, principally those less than 34 years (HR = 47.6, 95% CI = 26.8–84.4, p < 0.001) ( 20 ). In a Spanish study, age was found to be the only independent variable of increased PAOD risk among the traditional risk factors ( 21 ).…”

Section: Resultsmentioning

confidence: 99%

Novel Insights in Systemic Lupus Erythematosus and Atherosclerosis

2018

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IntroductionThe systemic inflammatory nature of systemic lupus erythematosus (SLE) is well patent not only in the diverse clinical manifestations of the disease but also in the increased risk of premature atherosclerosis and cardiovascular events (CVE), making SLE one of the most complex diseases to study and manage in clinical practice.AimTo travel from old aspects to modern insights on the physiopathology, new molecular biomarkers, imaging methods of atherosclerosis assessment, and the potential treatments of atherosclerosis in SLE.MethodsWe conducted a literature search using PubMed database and performed a critical review.Conclusion/discussionSeveral developments have taken place in the understanding of the relationship between SLE and premature atherosclerosis. Nevertheless, cardiovascular diseases are still the major cause of reduced life expectancy in SLE and the main cause of death. The lack of standardization methods for the imaging assessment of atherosclerosis in SLE and the multifactorial nature of the disease are well patriated in the difficulty of achieving consistent and reproducible results among studies that focus in cardiovascular risk assessment and prediction. A raising number of molecular biomarkers of atherosclerosis have been proposed, but the combination of several biomarkers and risk factors may better estimate cardiovascular disease risk. Moreover, the development of effective therapies to prevent progression of atherosclerosis and CVE shall address systemic inflammation.

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“…Any other clinical data in the time of the diagnostic and inclusion, or cardiovascular risk factors, lupus specific related factors and corticosteroid therapy were correlated with ABI abnormalities (Tables 3-6). Whether atherosclerosis in coronary artery, has been widely studied in the literature, peripheral arterial disease has been infrequently described [8] [17]. We reported, in our best knowledge, we reported the first study in sub-Saharan Africa, who compared ABI in patients with SLE between controls.…”

Section: Resultsmentioning

confidence: 92%

“…ABI has facilitated the detection of subclinical PAD [14]. However, there are very limited data about abnormal ABI in patients with SLE [8] [17]. The aim of the present study was to compare ABI between SLE patients and controls.…”

Section: Introductionmentioning

confidence: 95%

Ankle-Brachial Index in Systemic Lupus Erythematosus: A Senegalese Case-Control Study

Kane¹,

Sow²,

Aw³

et al. 2019

WJCD

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Systemic lupus erythematosus (SLE) is associated with accelerated atherosclerosis and increasing cardiovascular risk which is recognized as a major cause of morbidity and death. Whether subclinical atherosclerosis has been evaluated by several methods, there are very limited data about Ankle-Brachial Index (ABI) in patients with systemic lupus erythematosus. The aim of the present study was to compare this index, between SLE patients and controls. We conducted a case-control study in the Department of Internal Medicine of our institution during the period from August 1, 2017 to December 31, 2018. We included 100 subjects, including 50 SLE patients and 50 control cases. This included 44 women and 6 men in patients with an identical distribution in controls. The mean age was 33.5 ± 11.3 years for cases and 33.3 ± 11.3 years (p-value: 0.93) for controls subjects. There was higher frequency of cardiovascular risk factors such as dyslipidemia (p-value at 0.009), low level of serum HDL-cholesterol (p-value < 0.001), hypertriglyceridemia (p-value at 0.000) and hyperuricemia (p-value at 0.000) in patients with SLE. Overweight/obesity was higher in controls subjects (p-value at 0.028). There was no statistically significant difference in the frequency of diabetes-mellitus, smoking and high blood pressure. The abnormally ABI was recorded in 19 patients with SLE (38%) and 8 controls (16%) with a p-value: 0.01 and odds ratio: 3.22. Eight patients (16%) and four controls (8%) had low ABI without significant difference (p-value: 0.11 but odds-ratio at 2.98). Eleven patients with SLE (22%) and five controls (10%) had high ABI (p-value: 0.05 and odds-ratio: 3.24). In patients with SLE only disease activity (cSLEDAI) at the inclusion of the study was correlated to abnormal ABI. Conclusion: This

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Risk of Peripheral Arterial Occlusive Disease in Patients With Systemic Lupus Erythematosus

Cited by 29 publications

References 35 publications

Predictors of peripheral arterial disease in SLE change with patient’s age

Predictors of peripheral arterial disease in SLE change with patient’s age

Novel Insights in Systemic Lupus Erythematosus and Atherosclerosis

Ankle-Brachial Index in Systemic Lupus Erythematosus: A Senegalese Case-Control Study

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