Risk of pneumonia and pneumococcal disease in people with severe mental illness: English record linkage studies

Seminog, Olena; Goldacre, Michael J

doi:10.1136/thoraxjnl-2012-202480

Cited by 162 publications

(148 citation statements)

References 28 publications

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“…Further, we believe that this is also the first study to report age-specific RRs for different types of dementia in patients with different types of diabetes from the same population. The reference cohort has been used extensively in previous studies and has been shown to report plausible rates for a variety of conditions [15][16][17]. Furthermore, our obtained RR estimates for type 2 diabetes, although lower, are in agreement with the literature, thus lending credibility to our estimates for type 1 diabetes.…”

Section: Strengths and Limitationssupporting

confidence: 81%

“…The file includes deaths registered up to 31 December 2011. The methods used were similar to those described in previous studies [15,16], and were, briefly, as follows.…”

Section: Population and Datamentioning

confidence: 99%

“…This is based on a 'reference group' of conditions that has been used in other studies of disease associations [15,17]. The standard epidemiological practice was followed for hospital controls: selecting a diverse range of conditions rather than a narrow range (in case the latter are themselves atypical in the associated risk of dementia).…”

Section: Population and Datamentioning

confidence: 99%

See 2 more Smart Citations

Risk of dementia in patients hospitalised with type 1 and type 2 diabetes in England, 1998–2011: a retrospective national record linkage cohort study

2015

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Section: Strengths and Limitationssupporting

confidence: 81%

“…The file includes deaths registered up to 31 December 2011. The methods used were similar to those described in previous studies [15,16], and were, briefly, as follows.…”

Section: Population and Datamentioning

confidence: 99%

Section: Population and Datamentioning

confidence: 99%

See 1 more Smart Citation

Risk of dementia in patients hospitalised with type 1 and type 2 diabetes in England, 1998–2011: a retrospective national record linkage cohort study

2015

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“…13,14 From RESULTS Observed and expected numbers and rate ratios comparing ALS in each autoimmune group with the control cohort are shown in the table. The rate ratios were significantly high (p , 0.01) for ALS associated with a prior diagnosis-at least 1 year before ALS-of asthma, celiac disease, multiple sclerosis (MS), myasthenia gravis, myxoedema, polymyositis, Sjögren syndrome, and systemic lupus erythematosus.…”

mentioning

confidence: 99%

“…11 There are no clear human lymphocyte antigen associations. 12 METHODS An all-England national record-linkage dataset of Hospital Episode Statistics and mortality data (1999-2011) 13 was used to undertake studies of cohorts of people with each of a range of autoimmune disorders, compared with a control cohort without these diseases, to determine the risk of subsequent ALS in each cohort. A similar analysis was undertaken on a regional record-linkage dataset, the Oxford record-linkage study, using its data from an earlier period .…”

mentioning

confidence: 99%

Autoimmune disease preceding amyotrophic lateral sclerosis

et al. 2013

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Objective: To study whether the risk of amyotrophic lateral sclerosis (ALS) is increased in people with prior autoimmune disease.Methods: An all-England hospital record-linkage dataset spanning 1999-2011 was used.Cohorts were constructed of people with each of a range of autoimmune diseases; the incidence of ALS in each disease cohort was compared with the incidence of ALS in a cohort of individuals without prior admission for the autoimmune disease.Results: There were significantly more cases than expected of ALS associated with a prior diagnosis of asthma, celiac disease, younger-onset diabetes (younger than 30 years), multiple sclerosis, myasthenia gravis, myxedema, polymyositis, Sjögren syndrome, systemic lupus erythematosus, and ulcerative colitis. Conclusions:

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Preexisting Neuropsychiatric Conditions and Associated Risk of Severe COVID-19 Infection and Other Acute Respiratory Infections

et al. 2023

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ImportanceEvidence indicates that preexisting neuropsychiatric conditions confer increased risks of severe outcomes from COVID-19 infection. It is unclear how this increased risk compares with risks associated with other severe acute respiratory infections (SARIs).ObjectiveTo determine whether preexisting diagnosis of and/or treatment for a neuropsychiatric condition is associated with severe outcomes from COVID-19 infection and other SARIs and whether any observed association is similar between the 2 outcomes.Design, Setting, and ParticipantsPrepandemic (2015-2020) and contemporary (2020-2021) longitudinal cohorts were derived from the QResearch database of English primary care records. Adjusted hazard ratios (HRs) with 99% CIs were estimated in April 2022 using flexible parametric survival models clustered by primary care clinic. This study included a population-based sample, including all adults in the database who had been registered with a primary care clinic for at least 1 year. Analysis of routinely collected primary care electronic medical records was performed.ExposuresDiagnosis of and/or medication for anxiety, mood, or psychotic disorders and diagnosis of dementia, depression, schizophrenia, or bipolar disorder.Main Outcomes and MeasuresCOVID-19–related mortality, or hospital or intensive care unit admission; SARI-related mortality, or hospital or intensive care unit admission.ResultsThe prepandemic cohort comprised 11 134 789 adults (223 569 SARI cases [2.0%]) with a median (IQR) age of 42 (29-58) years, of which 5 644 525 (50.7%) were female. The contemporary cohort comprised 8 388 956 adults (58 203 severe COVID-19 cases [0.7%]) with a median (IQR) age of 48 (34-63) years, of which 4 207 192 were male (50.2%). Diagnosis and/or treatment for neuropsychiatric conditions other than dementia was associated with an increased likelihood of a severe outcome from SARI (anxiety diagnosis: HR, 1.16; 99% CI, 1.13-1.18; psychotic disorder diagnosis and treatment: HR, 2.56; 99% CI, 2.40-2.72) and COVID-19 (anxiety diagnosis: HR, 1.16; 99% CI, 1.12-1.20; psychotic disorder treatment: HR, 2.37; 99% CI, 2.20-2.55). The effect estimate for severe outcome with dementia was higher for those with COVID-19 than SARI (HR, 2.85; 99% CI, 2.71-3.00 vs HR, 2.13; 99% CI, 2.07-2.19).Conclusions and RelevanceIn this longitudinal cohort study, UK patients with preexisting neuropsychiatric conditions and treatments were associated with similarly increased risks of severe outcome from COVID-19 infection and SARIs, except for dementia.

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Risk of pneumonia and pneumococcal disease in people with severe mental illness: English record linkage studies

Cited by 162 publications

References 28 publications

Risk of dementia in patients hospitalised with type 1 and type 2 diabetes in England, 1998–2011: a retrospective national record linkage cohort study

Risk of dementia in patients hospitalised with type 1 and type 2 diabetes in England, 1998–2011: a retrospective national record linkage cohort study

Autoimmune disease preceding amyotrophic lateral sclerosis

Preexisting Neuropsychiatric Conditions and Associated Risk of Severe COVID-19 Infection and Other Acute Respiratory Infections

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