Risk of Postoperative Performance Status Worsening after Resection of Lesions Involving the Motor Pathway: A Multinomial Logistic Regression Model

Raco, Antonino; Pesce, Alessandro; Fraschetti, Flavia; D’Andrea, Giancarlo; Polli, Filippo Maria; Acqui, Michele; Frati, Alessandro

doi:10.1055/s-0037-1617756

Cited by 13 publications

(3 citation statements)

References 45 publications

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“…42 In another cohort of 92 patients with gliomas and metastases involving the motor pathway, female sex, among other factors, was associated with a poorer functional prognosis and a poorer quality of life. 43 In a recent cohort of 112 low-grade diffuse glioma, a high fatigue according to the European Organisation for Research and Treatment of Cancer (EORTC) fatigue subscale was noted in 45% of the patients preoperatively and in 42% of the patients post-operatively. Female sex was associated with preoperative fatigue only, whereas male sex was not associated with fatigue.…”

Section: Are There Sex-specific Differences In Safety Tolerability Amentioning

confidence: 99%

Sex-specific aspects of epidemiology, molecular genetics and outcome: primary brain tumours

Rhun

Weller

2020

ESMO Open

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Recent years have seen a great interest in sex-specific aspects of many diseases, including cancer, in part because of the assumption that females have often not been adequately represented in early drug development and determination of safety, tolerability and efficacy in clinical trials. Brain tumours represent a highly heterogeneous group of neoplastic diseases with strong variation of incidence by age, but partly also by sex. Most gliomas are more common in men whereas meningiomas, the most common primary intracranial tumours, are more common in females. Potential sex-specific genetic risk factors and specific sex biology have been reported in a tumour-specific manner. Several small studies have indicated differences in tolerability and safety of, as well as benefit from, treatment by sex, but no conclusive data have been generated. Exploring sex-specific aspects of neuro-oncology should be studied more systematically and in more depth in order to uncover the biological reasons for known sex differences in this disease.

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Section: Are There Sex-specific Differences In Safety Tolerability Amentioning

confidence: 99%

Sex-specific aspects of epidemiology, molecular genetics and outcome: primary brain tumours

Rhun

Weller

2020

ESMO Open

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“…The extent of surgery, however, depends on the location of the tumor. For example, patients with gliomas that affect the motor pathway can be susceptible to postoperative paresis or plegia, which would worsen the quality of life ( 9 ). This potential for complications must be taken into account when evaluating the extent of resection.…”

Section: Discussionmentioning

confidence: 99%

“…Survival after glioma diagnosis is influenced by patient age, IDH mutation status, extent of surgery, location of the tumor, and perioperative Karnofsky performance score (8)(9)(10)(11)(12)(13)(14). Preoperative epileptic seizure is associated with better survival in patients with diffuse glioma (15)(16)(17), whereas cognitive disorder has been associated with worse survival, although not as an independent factor (18).…”

Section: Introductionmentioning

confidence: 99%

Motor dysfunction as a primary symptom predicts poor outcome: multicenter study of glioma symptoms

Kivioja,

Posti,

Sipilä

et al. 2024

Front. Oncol.

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Background and objectivesThe objectives of this study were to investigate the prognostic value of primary symptoms and leading symptoms in adult patients with diffuse infiltrating glioma and to provide a clinical perspective for evaluating survival.MethodsThis study included a retrospective cohort from two tertiary university hospitals (n = 604, 2006–2013, Tampere University Hospital and Turku University Hospital) and a prospective cohort (n = 156, 2014–2018, Tampere University Hospital). Preoperative symptoms were divided into primary and leading symptoms. Results were validated with the newer WHO 2021 classification criteria.ResultsThe most common primary symptoms were epileptic seizure (30.8% retrospective, 28.2% prospective), cognitive disorder (13.2% retrospective, 16.0% prospective), headache (8.6% retrospective, 12.8% prospective), and motor paresis (7.0% retrospective, 7.1% prospective). Symptoms that predicted better survival were epileptic seizure and visual or other sense-affecting symptom in the retrospective cohort and epileptic seizure and headache in the prospective cohort. Predictors of poor survival were cognitive disorder, motor dysfunction, sensory symptom, tumor hemorrhage, speech disorder and dizziness in the retrospective cohort and cognitive disorder, motor dysfunction, sensory symptom, and dizziness in the prospective cohort. Motor dysfunction served as an independent predictor of survival in a multivariate model (OR = 1.636).ConclusionPrimary and leading symptoms in diffuse gliomas are associated with prognoses in retrospective and prospective settings. Motor paresis was an independent prognostic factor for poor survival in multivariate analysis for grade 2-4 diffuse gliomas, especially in glioblastomas.

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Health-Related Quality of Life Related to Toxicity Treatments in Central Nervous System Metastases

Walbert

Horta

2019

Central Nervous System Metastases

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Risk of Postoperative Performance Status Worsening after Resection of Lesions Involving the Motor Pathway: A Multinomial Logistic Regression Model

Abstract: In our experience, factors associated with worse functional prognosis and quality of life were a poor preoperative performance status, female gender, operating on a recurrent lesion, involvement of the left corticospinal tract, and surgical or medical postoperative complications.

Cited by 13 publications

References 45 publications

Sex-specific aspects of epidemiology, molecular genetics and outcome: primary brain tumours

Sex-specific aspects of epidemiology, molecular genetics and outcome: primary brain tumours

Motor dysfunction as a primary symptom predicts poor outcome: multicenter study of glioma symptoms

Health-Related Quality of Life Related to Toxicity Treatments in Central Nervous System Metastases

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