Risk of Pregnancy Complications and Low Birth Weight Offsprings in Korean Women With Rheumatic Diseases: A Nationwide Population-Based Study

Abstract

Background To determine the risk of pregnancy complications and adverse offspring outcomes in Korean women with rheumatic diseases (RDs). Methods Women aged 20–44 years with pregnancies ending in delivery were identified from the National Health Insurance Service-National Health Information Database (2009–2016). Women with RD including systemic lupus erythematosus (SLE), seropositive rheumatoid arthritis (SPRA), and ankylosing spondylitis (AS) (n = 4,284) were age-matched with controls (n = 26,023). Outcome variables included threatened abortion (TA), preterm birth (PB), preeclampsia/eclampsia (PE/E), intrauterine growth retardation (IGR), urinary tract infection, low birth weight (LBW) offsprings, and offspring death within 1 year of birth. Results Women with RDs had increased risks for cesarean section delivery (odds ratio [OR], 1.5; 95% confidence interval [CI], 1.4–1.6), TA (OR, 1.4; 95% CI, 1.2–1.5), PB (OR, 2.4; 95% CI, 1.9–3.2), PE/E (OR, 4.4; 95% CI, 3.3–5.9), and IGR (OR, 2.4; 95% CI, 2.0–3.1) than the controls. The risk of pregnancy complications was increased in SLE and SPRA pregnancies but not in AS pregnancies. Offsprings of women with RDs had an increased risk of LBW (OR, 4.0; 95% CI, 3.2–4.9). The offspring mortality rate within 1 year of birth was higher in women with RDs (6.2/10,000 persons) than in the controls (4.9/10,000 persons). Conclusion Women with RDs are at a risk of developing pregnancy complications, and the risk of LBW offsprings and offspring death within 1 year of birth is increased in these women. Therefore, this population requires special attention during their childbearing years.

Global, regional and national temporal trends in prevalence for musculoskeletal disorders in women of childbearing age, 1990–2019: an age-period-cohort analysis based on the Global Burden of Disease Study 2019

“…In 2015, the United Nations established the Targets of Sustainable Development Goal 3 to reduce the global maternal mortality ratio to less than 70/100 000 live births by 2030 3. Women with MSK disorders are especially relevant as this group is at high risk of developing severe pregnancy complications, leading to striking maternal morbidity and mortality 4 5. Concerns have been prominent that a global overview and analysis of MSK disorders prevalence in WCBA is lacking, suggesting an insufficient attention to this special population, which may limit the realisation of related items in Targets of Sustainable Development Goal 3.…”

Espondilite anquilosante na gestação

“…Para Park et al, (2022), mulheres gestantes que possuem doenças reumáticas, são consideradas gestações de alto risco.…”

Causal association between rheumatoid arthritis and pregnancy loss and intrauterine growth retardation: A bidirectional two-sample Mendelian randomization study

“…[6] Miscarriage and IUGR may be the fate of gestational women with RA. [7] Many previous observational studies have suggested a close relationship between RA and pregnancy loss and IUGR, [8,9] which have a complex etiology that has not yet been fully elucidated, but the pathogenesis of them is related to genetics and environment. [10,11] RA, along with pregnancy loss and IUGR, may be influenced by genetic factors, and a number of specific genetic variants may lead to increased susceptibility of individuals to diseases.…”