Risk of premature coronary atherosclerosis in patients with nonalcoholic fatty liver disease

Abstract

OBJECTIVE:In the current literature, there are few studies investigating the relationship between premature coronary atherosclerosis and nonalcoholic fatty liver disease. We aimed to evaluate the relationship between nonalcoholic fatty liver disease and premature coronary atherosclerosis. METHODS: In this cross-sectional study, female patients aged <55 years and male patients aged <50 years were enrolled. Both male and female patients underwent coronary angiography and abdomen ultrasonography between 2014 and 2019. A stepwise binary logistic regression analysis was carried out to evaluate the independent variables related to premature coronary atherosclerosis and nonalcoholic fatty liver disease. A p-value<0.05 was considered statistically significant. RESULTS: nonalcoholic fatty liver disease was present in 44% of patients (n=377). Notably, 62% of the patients were female and the mean age was 44.5 (39-49) years. In a multivariate analysis, nonalcoholic fatty liver disease was shown to be an independent risk factor of premature coronary atherosclerosis (OR 1.438; 95%CI, 1.050-1.969; p=0.024). CONCLUSIONS: The presence of nonalcoholic fatty liver disease is an important independent risk factor for the development of premature coronary atherosclerosis.

Non-Alcoholic Fatty Liver Disease, Atherosclerosis, and Cardiovascular Disease in Asia

“…[ 36 , 37 , 38 , 39 , 40 , 41 , 42 ]) [ 36 , 37 , 38 , 39 , 40 , 41 , 42 ]. These results were in accordance with a previous study that defined premature coronary atherosclerosis as an outcome [ 14 ]. The most notable difference between these studies was that the prevalence of NAFLD was 57.4% in the Malaysian study as diagnosed using the Fibroscan, which is higher than the others [ 37 ].…”

“…The non-invasive approaches as a definition for NAFLD allowed a wider range of investigations on the association of NAFLD with both intrahepatic and extrahepatic diseases [ 13 ]. Presently, NAFLD has been identified as an important and independent risk factor for the development of several extrahepatic diseases, including atherosclerosis, cardiovascular disease (CVD), diabetes, and dementia [ 14 , 15 , 16 , 17 ]. Herein, we reviewed up-to-date literature regarding the effects of NAFLD on the risk of atherosclerosis and CVD in Asia along with potential underlying biological mechanisms and therapeutic approaches to lower the NAFLD-related CVD risk.…”

Genetic and Lifestyle Risk Factors of Metabolic Dysfunction-Associated Fatty Liver Disease and Its Relationship with Premature Coronary Artery Disease: A Study on the Pars Cohort

“…Premature coronary artery disease (CAD), an atherosclerotic condition that affects individuals under the age of 45 (and up to 65), is an early manifestation of this condition. 16 Despite existing evidence that MAFLD is also associated with other chronic diseases, the negative effect of MAFLD on CVD risk is increasing due to the obesity/MetS epidemic in the general population. 17 Genetics plays a crucial role in the development of MAFLD.…”