Risk of psychological sequelae among coronavirus disease‐2019 survivors: A nationwide cohort study in South Korea

Oh, Tak Kyu; Park, Hye Youn; Song, In Ae

doi:10.1002/da.23124

Cited by 23 publications

(27 citation statements)

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“…Using the same database (NHIS COVID-19), we recently reported that COVID-19 survivors were at higher risk of psychological sequalae. 8 However, the results of the previous study differ from those of the current study in several ways. First, the previous study was based on the database from 1 January to 4 June 2020, whereas the current study used the updated data from 1 January to 1 December 2020.…”

Section: Discussioncontrasting

confidence: 94%

“… 10 In South Korea, a high association of psychological sequelae in COVID-19 survivors has been reported in previous studies. 8 , 9 However, to date, studies have only evaluated the total prevalence of mental illness during a short-term follow-up period of 1 month. 9 , 11 Thus, there is an urgent need to evaluate the overall mental illness levels with a longer follow-up period.…”

Section: Introductionmentioning

confidence: 99%

“… 8 , 9 However, to date, studies have only evaluated the total prevalence of mental illness during a short-term follow-up period of 1 month. 9 , 11 Thus, there is an urgent need to evaluate the overall mental illness levels with a longer follow-up period.…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of mental illness among COVID-19 survivors in South Korea: nationwide cohort

et al. 2021

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Background Mental illness among survivors of coronavirus disease 2019 (COVID-2019) during the post-illness period is an emerging and important health issue. Aims We aimed to investigate the prevalence of mental illness and the associated factors for its development among COVID-2019 survivors. Method From 1 January to 4 June 2020, data were extracted from the National Health Insurance Service COVID-19 database in South Korea. Patients with COVID-19 were defined as those whose test results indicated that they had contracted the infection, regardless of disease severity. COVID-19 survivors were defined as those who recovered from the infection. The primary end-point was the development of mental illness, which was evaluated between 1 January and 1 December 2020. Results A total 260 883 individuals were included in this study, and 2.36% (6148) were COVID-19 survivors. The COVID-19 survivors showed higher prevalence of mental illness than the control group (12.0% in the COVID-19 survivors v. 7.7% in the control group; odds ratio (OR) = 2.40, 95% CI 2.21–2.61, P < 0.001). Additionally, compared with the control group, the no specific treatment for COVID-19 group (OR = 2.23, 95% CI 2.03–2.45, P < 0.001) and specific treatment for COVID-19 group (OR = 3.27, 95% CI 2.77–3.87, P < 0.001) showed higher prevalence of mental illness among survivors. Conclusions In South Korea, COVID-19 survivors had a higher risk of developing mental illness compared with the rest of the populations. Moreover, this trend was more evident in COVID-19 survivors who experienced specific treatment in the hospital.

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Section: Discussioncontrasting

confidence: 94%

Section: Introductionmentioning

confidence: 99%

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Prevalence of mental illness among COVID-19 survivors in South Korea: nationwide cohort

et al. 2021

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“…Only two studies reported symptoms in control groups, both drawn from healthy populations and neither formally matched to the respective COVID-19 groups. (36,51) Each reported higher frequencies of sleep disorder, fatigue, dizziness, depression, anxiety, and/or psychosis in COVID-19 survivors compared to controls (Table S8).…”

Section: Figure 3 and Table 2 About Herementioning

confidence: 99%

Persistent neuropsychiatric symptoms after COVID-19: a systematic review and meta-analysis

Badenoch

Rengasamy

Jansen

et al. 2021

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SUMMARYBackgroundThe nature and extent of persistent neuropsychiatric symptoms after COVID-19 are not established. To help inform mental health service planning in the pandemic recovery phase, we systematically determined the prevalence of neuropsychiatric symptoms in survivors of COVID-19.MethodsFor this pre-registered systematic review and meta-analysis (PROSPERO ID CRD42021239750) we searched PubMed, EMBASE, CINAHL and PsycINFO to 20th February 2021, plus our own curated database. We included peer-reviewed studies reporting neuropsychiatric symptoms at post-acute or later time-points after COVID-19 infection, and in control groups where available. For each study a minimum of two authors extracted summary data. For each symptom we calculated a primary pooled prevalence using generalised linear mixed models. Heterogeneity was measured with I2. Subgroup analyses were conducted for COVID-19 hospitalisation, severity, and duration of follow-up.FindingsFrom 2,844 unique titles we included 51 studies (n=18,917 patients). The mean duration of follow-up after COVID-19 was 77 days (range 14-182 days). Study quality was generally moderate. The most frequent neuropsychiatric symptom was sleep disturbance (pooled prevalence=27·4% [95%CI 21·4- 34·4%]), followed by fatigue (24·4% [17·5-32·9%]), objective cognitive impairment (20·2% [10·3-35·7%]), anxiety (19·1%[13·3-26·8%]), and post-traumatic stress (15·7% [9·9-24·1%]). Only two studies reported symptoms in control groups, both reporting higher frequencies in Covid-19 survivors versus controls. Between-study heterogeneity was high (I2=79·6%-98·6%). There was little or no evidence of differential symptom prevalence based on hospitalisation status, severity, or follow-up duration.InterpretationNeuropsychiatric symptoms are common and persistent after recovery from COVID-19. The literature on longer-term consequences is still maturing, but indicates a particularly high frequency of insomnia, fatigue, cognitive impairment, and anxiety disorders in the first six months after infection.FundingJPR is supported by the Wellcome Trust (102186/B/13/Z).IK is funded through the NIHR (Oxford Health Biomedical Research Facility, Development and Skills Enhancement Award) and the Medical Research Council (Dementias Platform UK and Deep and Frequent Phenotyping study project grants).HH is funded by the German Research Foundation (DFG, Grant: HO 1286/16-1). The funders played no role in the design, analysis or decision to publish.RESEARCH IN CONTEXTEvidence before this studyNeuropsychiatric symptoms like cognitive impairment, fatigue, insomnia, depression and anxiety can be highly disabling. Recently there has been increasing awareness of persistent neuropsychiatric symptoms after COVID-19 infection, but a systematic synthesis of these symptoms is not available. In this review we searched five databases up to 20th February 2021, to establish the pooled prevalence of individual neuropsychiatric symptoms up to six months after COVID-19.Added value of this studyThis study establishes which of a range of neuropsychiatric symptoms are the most common after COVID-19. We found high rates in general, with little convincing evidence that these symptoms lessen in frequency during the follow-up periods studied.ImplicationsPersistent neuropsychiatric symptoms are common and appear to be limited neither to the post-acute phase, nor to recovery only from severe COVID-19. Our results imply that health services should plan for high rates of requirement for multidisciplinary services (including neurological, neuropsychiatric and psychological management) as populations recover from the COVID-19 pandemic.

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“…Rozpowszechnienie objawów PTSD u ocalonych zawierało się w zakresie od 10% [12] do 46,9% [13]. Rozpowszechnienie zaburzeń depresyjnych od 4,9% [14] do 38,1% [15]. Ryzyko śmieci samobójczej średniego stopnia rozpoznano u 22,2% ocalonych [12].…”

Section: Wstępunclassified

Czy ozdrowieńcy COVID-19 to przyszli pacjenci psychiatrów i psychologów? Szybki przegląd literatury naukowej

2021

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Risk of psychological sequelae among coronavirus disease‐2019 survivors: A nationwide cohort study in South Korea

Cited by 23 publications

References 35 publications

Prevalence of mental illness among COVID-19 survivors in South Korea: nationwide cohort

Prevalence of mental illness among COVID-19 survivors in South Korea: nationwide cohort

Persistent neuropsychiatric symptoms after COVID-19: a systematic review and meta-analysis

Czy ozdrowieńcy COVID-19 to przyszli pacjenci psychiatrów i psychologów? Szybki przegląd literatury naukowej

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