Risk of psychosis in Yorkshire South Asians

Saleem, Majid M.; Brewin, Anita; Ding, Catherine; Nazar, Qadeer; Robinson, Julie; Hosalli, Prakash; Nazari, Jamshid; Garnham, Mark; Inglehearn, Chris F.; Cardno, Alastair G.; Mahmood, Tariq

doi:10.20299/jpi.2019.007

Cited by 6 publications

(9 citation statements)

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“…However, risks are not known for these groups in West Yorkshire in the north of England, which is home to a number of immigrant communities particularly in the Bradford, Leeds and Kirklees districts. This multi-ethnic population previously provided an opportunity to study the risk of psychosis among South Asian ethnic groups (Saleem et al 2019). In this paper we report our findings in African, African-Caribbean and Mixed Ethnic groups.…”

Section: Introductionmentioning

confidence: 67%

Risk of psychosis in Yorkshire African, Caribbean and Mixed Ethnic communities

Hosalli¹,

Cardno²,

Brewin³

et al. 2021

j psych intensive care

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Background: An elevated risk of psychosis in migrant and ethnic minority groups has been frequently reported. Previous UK studies have found an elevated risk in African-Caribbean, African and Mixed Ethnic groups, but risks for these groups in West Yorkshire are not known.Aim: To carry out a naturalistic study of the relative risk of psychosis in Yorkshire African, African-Caribbean and Mixed Ethnic groups as compared with the British White population.Method: We used data from Early Intervention for Psychosis services on 15–35 year-olds diagnosed with first episode psychosis (ICD-10, F20-29) in 2013–2015 and local census data to calculate risks.Results: Risk ratios (RR) are significantly increased in African (RR 3.23: 95% CI, 2.46, 4.25), African Caribbean (RR 3.15: 95% CI, 2.04, 4.85) and Mixed Ethnic group (RR 2.27: 95% CI, 1.77, 2.91).Conclusion: Risks are elevated but not as much as elsewhere in England. The reasons for this difference require further investigation.

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Section: Introductionmentioning

confidence: 67%

Risk of psychosis in Yorkshire African, Caribbean and Mixed Ethnic communities

Hosalli¹,

Cardno²,

Brewin³

et al. 2021

j psych intensive care

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“…Four of the articles explicitly state their epistemological and ontological positions (Ahmed, 2019;Islam et al, 2015;Vyas et al, 2021), however, eleven were deduced by the lead researcher based on the methodologies and methods of analysis within the respective reports (Agius et al, 2008;Agius et al, 2010;Bhikha et al, 2015;Casey et al, 2016;Das-Munshi et al, 2018;Ghali et al, 2013;McCabe & Priebe, 2004;Mirza et al, 2019;Penny et al, 2009;Saleem et al, 2019;Singh et al, 2015). To do this, the lead researcher examined the methods of each text to identify information regarding the ontologies and epistemologies that the studies adopted to execute their research.…”

Section: Resultsmentioning

confidence: 99%

“…Conversely past research suggests that supernatural beliefs hinder medical help-seeking (Zafar et al, 2008;Banerjee & Roy, 1998) however more recent research has determined that spiritual explanatory models to be of no significance to help-seeking behaviours, for example, DUP is not dependant on ethnicity (Singh et al, 2015), spiritual beliefs do not influence engagement (Casey et al, 2016), and risk of psychosis is not dependant on gender or ethnicity (Saleem et al, 2019).…”

Section: Facilitatorsmentioning

confidence: 95%

“…British South Asians were able to access faith healing alongside medical treatments successfully without compromising their level of care. Additionally, many studies found that the spiritual and medical models could work well together (Singh et al, 2015;Casey et al, 2016), and ethnicity caused no delay to help-seeking (Singh et al, 2015;Casey et al, 2016;Saleem et al, 2019).…”

Section: Facilitatorsmentioning

confidence: 99%

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Cultural inequalities in access to Early Intervention for Psychosis services in the United Kingdom

Friskney¹,

Branney²,

Iqbal³

et al. 2023

Preprint

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While reviews of evidence suggests that early intervention for psychosis can reduce risk of transition to psychosis, they also highlight that we need to understand early intervention cross culturally and for different health service models. Black and ethnic minority groups are disproportionately disadvantaged in mental healthcare settings in many Western countries and in the United Kingdom and are more likely to be treated in acute settings rather than early intervention. The primary aim of this systematic review was to explore the experiences of South Asian people accessing early intervention services. Five databases were searched, and data were analysed using narrative synthesis from 15 articles that met the inclusion criteria. Only three articles used complementary theories that examine, spirituality, and explanatory models of illness to inform their research. Looking at participants' experiences, six narratives were themed as barriers to access (“declined treatment”, “systemic barriers”, “lack of understanding”, “intersectional stigma and shame”, “hardships”, “interpreters”) and six were themed as facilitators (“support systems”, “factors that influence help-seeking”, “therapies offered”, “what is required”, “no significance”, “what works well”). A recurring finding is the lack of understanding between service users and providers. Therefore, signposting needs improvement, pathways need to become clearer and culturally appropriate treatments need development based on the needs of the end user.

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“… 21 There is an elevated prevalence of schizophrenia and other psychoses in the West Yorkshire Pakistani population. 22 Like other migrant groups, they are subject to environmental risk factors such as low birth weight 23 and risks associated with residence in deprived inner city areas. 24 However, we hypothesized that part of the increase in risk could be due to recessive alleles of major effect predisposing to psychosis.…”

Section: Introductionmentioning

confidence: 99%

A Recessively Inherited Risk Locus on Chromosome 13q22-31 Conferring Susceptibility to Schizophrenia

Mahmood

El‐Asrag

Poulter

et al. 2020

Schizophrenia Bulletin

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We report a consanguineous family in which schizophrenia segregates in a manner consistent with recessive inheritance of a rare, partial-penetrance susceptibility allele. From 4 marriages between 2 sets of siblings who are half first cousins, 6 offspring have diagnoses of psychotic disorder. Homozygosity mapping revealed a 6.1-Mb homozygous region on chromosome 13q22.2-31.1 shared by all affected individuals, containing 13 protein-coding genes. Microsatellite analysis confirmed homozygosity for the affected haplotype in 12 further apparently unaffected members of the family. Psychiatric reports suggested an endophenotype of milder psychiatric illness in 4 of these individuals. Exome and genome sequencing revealed no potentially pathogenic coding or structural variants within the risk haplotype. Filtering for noncoding variants with a minor allele frequency of <0.05 identified 17 variants predicted to have significant effects, the 2 most significant being within or adjacent to the SCEL gene. RNA sequencing of blood from an affected homozygote showed the upregulation of transcription from NDFIP2 and SCEL. NDFIP2 is highly expressed in brain, unlike SCEL, and is involved in determining T helper (Th) cell type 1 and Th2 phenotypes, which have previously been implicated with schizophrenia.

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Risk of psychosis in Yorkshire South Asians

Cited by 6 publications

References 0 publications

Risk of psychosis in Yorkshire African, Caribbean and Mixed Ethnic communities

Risk of psychosis in Yorkshire African, Caribbean and Mixed Ethnic communities

Cultural inequalities in access to Early Intervention for Psychosis services in the United Kingdom

A Recessively Inherited Risk Locus on Chromosome 13q22-31 Conferring Susceptibility to Schizophrenia

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