Risk of Radiation Retinopathy in Patients With Orbital and Ocular Lymphoma

Kaushik, Megha; Pulido, José S.; Schild, Steven E.; Stafford, Scott L.

doi:10.1016/j.ijrobp.2011.12.097

Cited by 54 publications

(37 citation statements)

References 21 publications

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“…Our patient, who was diabetic, lost vison (final acuity of counting fingers) due to cystoid macular edema, cotton-wool spots, retinal hemorrhages, and neovascularization of the iris requiring full panretinal photocoagulation treatment and despite multiple anti-VEGF intravitreal injections. Diabetes has been reported to increases the risk of radiation retinopathy [38]. In our patient, development of unilateral radiation retinopathy may have been exacerbated by diabetic status.…”

Section: Discussionmentioning

confidence: 53%

“…Only 4 patients lost 2 lines or more of vision after radiation. Few studies have reported severe radiation retinopathy with a total radiation dose of <40 Gy as observed in 1 of our patients (34 Gy in 20 fractions) [6,38]. Radiation-induced toxicity to the retina has been documented in 5 and 50% of patients at 5 years with fractionated doses of 45-50 and 55 Gy, respectively [39].…”

Section: Discussionmentioning

confidence: 87%

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Extranodal Marginal Zone Lymphoma of Ocular Adnexa: Outcomes following Radiation Therapy

Platt¹,

Zahrani²,

Singh

et al. 2017

Ocul Oncol Pathol

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Aim: The aim of this study was to report outcomes following radiation therapy in patients with biopsy-proven extranodal marginal zone lymphoma of the ocular adnexa and uvea. Methods: Records from a single institution were retrospectively reviewed from January 1997 to December 2015. The mean follow-up duration was 38 months (range 0-194). Radiation therapy was administered to 77 eyes (60 patients); 57 of the 77 eyes (74%) were treated with radiation only (range 20-36 Gy, median 15 fractions). Radiation cataract, radiation retinopathy, and optic neuropathy assessments were performed on all eyes treated with radiation. Results: 100% of the 47 patients treated with radiation therapy only had local control with an average dose of 26.5 Gy (median 25.2 [range 20-36] Gy; 150-200 cGy per fraction). Four patients lost 2 lines or more of vision after radiation. The most common complication of radiation therapy was cataract formation/progression in 19 eyes (25%). Radiation retinopathy was observed only in 1 patient (1%). Conclusion: Our results confirm that radiation therapy (median 25 Gy) for extranodal marginal zone lymphoma of the ocular adnexa is associated with high local control and low risk of visually significant complications.

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Section: Discussionmentioning

confidence: 53%

Section: Discussionmentioning

confidence: 87%

Extranodal Marginal Zone Lymphoma of Ocular Adnexa: Outcomes following Radiation Therapy

Platt¹,

Zahrani²,

Singh

et al. 2017

Ocul Oncol Pathol

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“…25 Severe radiation retinopathy is rarely seen in patients receiving <40 Gy of radiation, 29 but as the radiation dose approaches or exceeds 40 Gy, so too do the cases of radiation retinopathy. 16,30 Various treatment techniques can be used for the management of radiation retinopathy, including laser therapy, hyperbaric oxygen therapy, administration of pentoxifylline, photodynamic therapy, anti-VEGF therapy, and steroid therapy. 31 Although we were successful in controlling disease locally, 29% of our patients experienced relapse either in regional or distant sites.…”

Section: Discussionmentioning

confidence: 99%

Radiotherapy in the Management of Orbital Lymphoma

Kharod

Herman

Morris

et al. 2018

American Journal of Clinical Oncology

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“…A dose >50 Gy is associated with RR development. However, there are RR cases reported with doses of <35 Gy [30–32]. Moreover, it has been reported that CT accompanying the radiation treatment can accelerate RR due to retinal vascular damage as happens in diabetic and hypertensive patients [31–33].…”

Section: Cases At Mayo Clinicmentioning

confidence: 99%

Macular edema is a rare finding in untreated vitreoretinal lymphoma: small case series and review of the literature

et al. 2017

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Background To determine the occurrence of macular edema (ME) in vitreoretinal lymphoma (VRL).MethodsRetrospective analysis of 17 patients (31 eyes) with VRL. A review of the literature was done as well.Results Nine patients (15 eyes) had fluorescein angiography and/or optical coherence tomography at presentation. In the ME group (six eyes of four patients), three patients (five eyes) had prior chemotherapy and radiation. Excluding eyes with radiation retinopathy (three eyes), rate of ME was 25% (3/12). When two unirradiated fellow eyes of eyes with radiation retinopathy were also excluded, ME rate was 10% (1/10). Excluding the eyes with intraocular surgery, the rate of ME was 0%. In the group without ME (nine eyes of six patients), one patient (one eye) was treated with chemotherapy and radiation and three patients (five eyes) with chemotherapy. Review of the literature showed that the ME was found between 2 and 60% of cases, but most of the cases with ME had prior interventions.ConclusionsMacular edema in VRL is not uncommon but usually related to prior interventions. Macular edema as an initial presentation of VRL is rare.

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Risk of Radiation Retinopathy in Patients With Orbital and Ocular Lymphoma

Cited by 54 publications

References 21 publications

Extranodal Marginal Zone Lymphoma of Ocular Adnexa: Outcomes following Radiation Therapy

Extranodal Marginal Zone Lymphoma of Ocular Adnexa: Outcomes following Radiation Therapy

Radiotherapy in the Management of Orbital Lymphoma

Macular edema is a rare finding in untreated vitreoretinal lymphoma: small case series and review of the literature

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