Objective
To estimate the seroprevalence of SARS-CoV-2 antibodies in healthcare personnel.
Methods
The Mayo Clinic Serology Screening Program was created to provide a voluntary, two-stage testing program for SARS-CoV-2 antibodies to healthcare personnel. The first stage utilized a dried blood spot screening test initiated on June 15, 2020. Those participants identified as reactive were advised to have confirmatory testing via a venipuncture. Venipuncture results through August 8, 2020 were considered. Consent and authorization for testing was required in order to participate in the screening program. This report, which was conducted under an institutional review board approved protocol, only includes employees who have further authorized their records for use in research.
Results
A total of 81,113 healthcare personnel were eligible for the program, and of these 29,606 participated in the screening program. A total of 4,284 (14.5%) of the dried blood spot test results were “reactive” and warranted confirmatory testing. Confirmatory testing was completed on 4,094 (96%) of the screen reactive with an overall seroprevalence rate of 0.60% (95% CI: 0.52% to 0.69%). Significant variation in seroprevalence was observed by region of the country and age group.
Conclusions
The seroprevalence for SARS-CoV-2 antibodies through August 8, 2020 was found to be lower than previously reported in other health care organizations. There was an observation that seroprevalence may be associated with community disease burden.