Risk of second primary cancer among patients with head and neck cancers: a pooled analysis of 13 cancer registries

Chuang, Shu-Chun; Scélo, Ghislaine; Tonita, Jon; Tamaro, Sharon; Jónasson, Jón Gunnlaugur; Kliewer, Erich V.; Hemminki, K.; Weiderpass, Elisabete; Pukkala, Eero; Tracey, Elizabeth; Friis, Søren; Pompe-Kirn, Vera; Brewster, David H.; Martos, Carmen; Chia, Kee‐Seng; Boffetta, Paolo; Brennan, Patrick McKinley; Hashibe, Mia

doi:10.1016/s1359-6349(08)71864-0

Cited by 97 publications

(172 citation statements)

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“…Second, the most frequent metachronous SPMs in Europe were lung cancers (Rennemo et al 2008;Chuang et al 2008), compared to upper GI tract cancers in Japan. Perhaps these results are due to the fact that less than onehalf of Japanese people have a mutant type of aldehyde dehydrogenase 2 (ALDH2) gene and are susceptible to upper GI tract cancers (Yokoyama et al 2005;Asakage et al 2007).…”

Section: Discussionmentioning

confidence: 99%

Distinct Features of Second Primary Malignancies in Head and Neck Cancer Patients in Japan

Shiga

Tateda

Katagiri

et al. 2011

Tohoku J. Exp. Med.

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Second primary malignancies (SPMs) are one of the most critical problems in treating head and neck cancer patients. Our hospital had 742 patients with a diagnosis of malignant head and neck tumors during the five-year period from 2002 to 2006. In this study, we analyzed 360 of those patients who were assumed to have risk factors such as alcohol and tobacco use: 106 oral, 120 laryngeal, 50 oropharyngeal and 84 hypopharyngeal cancer patients. Synchronous SPMs are defined as second cancers diagnosed at the same time or within 6 months of the diagnosis of the index head and neck cancers. There were 4 (3.8%) and 11 (10.4%) oral cancer patients, 11 (8.3%) and 8 (5.8%) laryngeal cancer patients, 7 (14.0%) and 4 (8.0%) oropharyngeal cancer patients, and 30 (28.6%) and 7 (8.3%) hypopharyngeal cancer patients with synchronous and metachronous SPMs, respectively. The number of metachronous patients with synchronous SPMs tended to increase during this time period. The frequencies of SPMs in oropharyngeal and hypopharyngeal cancer patients are similar to those in oral and laryngeal cancer patients. Notably, the most frequent SPMs are upper gastrointestinal tract cancers in Japan, compared to lung cancers in Europe. The five-year overall survival rate of patients with synchronous SPMs was significantly poorer than that of patients without any other tumor except for the index cancer, according to the Kaplan-Meier analysis. In conclusion, searching for SPMs in the upper gastrointestinal tract is a critical issue in head and neck cancer patients in Japan.Keywords: diagnosis; head and neck cancer; prognosis; second primary malignancy; synchronous and metachronous Tohoku J. Exp. Med., 2011, 225 (1), 5-12. © 2011 Tohoku University Medical Press Squamous cell carcinoma of the head and neck is the sixth most common cancer worldwide and approximately 600,000 patients develop this type of cancer each year around the world. Despite marked improvements in locoregional control of head and neck squamous cell carcinomas over the past several decades, the overall survival rate of the patients has not changed (Pisani et al. 1999;Parkin et al. 2005). One major reason for the lack of improved overall survival of patients with head and neck cancers is the increased risk of developing a second primary malignancy (SPM). Most SPMs originate independently from the index cancers because these tumors are not clonally related as proven by genetic examination (Califano et al. 1999;Shiga et al. 2003). It is thought that this different clonal origin of SPMs results in treatment difficulties. There are two types of SPMs, metachronous and synchronous, and some patients have both types of SPMs. SPMs are critical problems that must be considered to treat patients with head and neck carcinomas. Such treatment happens to be very difficult in some cases because of the advanced stage of the disease and/or difficulties in the management of treatment strategies and timing especially when they have synchronous SPMs. It is well known that smoking and alcohol use are ...

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Section: Discussionmentioning

confidence: 99%

Distinct Features of Second Primary Malignancies in Head and Neck Cancer Patients in Japan

Shiga

Tateda

Katagiri

et al. 2011

Tohoku J. Exp. Med.

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“…Although the overall prevalence of colorectal neoplasm was not higher in the HNSCC group than the control group in this study, the same result as an earlier report, 6 this association between HNSCC and colorectal neoplasm can be explained by the shared carcinogens of cigarette smoking and alcohol drinking. 1,5 Advances in the prevention, treatment, and surveillance of HNSCC await a more complete understanding of the mechanism of the multifocality of this tumor. According to the field carcinogenesis concept, multiple cell groups independently undergo neoplastic transformation under the stress of regional carcinogenic activity.…”

Section: 허경미 등 두경부 암 환자에서 수술 전 위장내시경mentioning

confidence: 99%

“…Several studies provide evidence for this result. 1,3,[20][21][22][23] The previous prospective study reported that the rate of second esophageal primary tumors was 1.9% in the 268 HNSCC patients. 23 One recent study reported that esophageal surveillance was recommended because early detection of esophageal cancer in HNSCC patients led to a good prognosis.…”

Section: 허경미 등 두경부 암 환자에서 수술 전 위장내시경mentioning

confidence: 99%

“…1 Gastrointestinal malignancies in particular, such as gastric cancer and colorectal cancer, are often found. [1][2][3][4][5][6] SPT of the respiratory and upper digestive tract is the main cause of death after treatment in early-stage HNSCC patients. 7 In the first five years after treatment of the primary tumor, the rates for metachronous SPT reach approximately 15% to 25%.…”

Section: Introductionmentioning

confidence: 99%

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Is a Preoperative Gastrointestinal Endoscopy for Second Primary Cancer Detection in Head and Neck Cancer Necessary? Ten-year Registry Data

허경미

김미희

김진환

et al. 2016

Korean J Gastroenterol

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Background/Aims: In head and neck squamous cell carcinoma, second primary gastrointestinal tumors are not uncommon. However, it is unclear whether a screening endoscopy is needed for detecting gastrointestinal neoplasm in patients with head and neck cancer. Therefore, we analyzed the prevalence and independent risk factors for second primary gastrointestinal neoplasm in head and neck squamous cell carcinoma. Methods: A consecutive series of 328 patients with primary head and neck squamous cell carcinoma that underwent esophagogastroduodenoscopy or colonoscopy were included using our registry. An age-and sex-matched group of 328 control subjects was enrolled. We assessed risk factors of synchronous gastrointestinal cancer. Results: The prevalence of esophageal cancer with head and neck squamous cell carcinoma was significantly higher than that of the control group (1.5% vs. 0.0%, p=0.011). An age of 54 years or more (OR, 1.033; 95% CI, 1.008-1.059; p=0.009) and male gender (OR, 4.974; 95% CI, 1.648-15.013; p=0.004) were risk factors for concomitant colorectal cancer or adenomas in the head and neck squamous cell carcinoma patients. Conclusions: Preoperative colonoscopy can be recommended for detecting synchronous second primary colorectal lesions in head and neck squamous cell carcinoma patients with male sex regardless of age, and esophagogastroduodenoscopy is necessary in all head and neck squamous cell carcinoma patients for detecting esophageal cancer. (Korean J Gastroenterol 2016;68:23-28)

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“…2 In patients with head and neck squamous cell carcinoma (HNSCC), esophageal cancer is the most common synchronous cancer. [3][4][5][6] In Korea, esophageal cancer is detected in 5.0∼7.1% of patients with HNSCC 4,7 and occurs most frequently in HNSCC patients with tumors of the hypopharynx. 7,8 Related risk factors for esophageal cancer include a positive history of smoking.…”

Section: Introductionmentioning

confidence: 99%

Incidence of Gastric Cancer in Patients with Laryngeal Cancer

Seo

Kim

Park

et al. 2017

Korean J Helicobacter Up Gastrointest Res

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Background/Aims: Gastric cancer (GC) is the second most common cancer in Korea and the most common in men in the south of the country. We investigated the incidence of synchronous GC in patients with head and neck squamous cell carcinoma (HNSCC) in the southern part of Korea. Materials and Methods: We retrospectively reviewed the medical records of HNSCC patients treated between 2011 and 2014. In patients with synchronous GC, evaluation included a history of smoking and alcohol consumption, endoscopic findings, Campylobacter-like organism (CLO) test, and immunohistochemical analysis of preserved HNSCC tissues. Results: Analysis of the records of 153 HNSCC patients revealed tumors of the larynx in 56 patients (36.6%), of the pharynx in 74 patients (48.4%), and tumors at other locations in 23 patients (15.0%). The mean age of patients was 66.0 years, and the men:women ratio was 8:1. Synchronous cancers were detected in 12 patients. We observed esophageal squamous cell carcinoma (SCC) in five patients (3.3%), and gastric adenocarcinoma in seven patients (4.6%). Synchronous GC was detected in patients with laryngeal SCC. All cases of GC were classified as early GC. Conclusions: Synchronous GC was as frequent as esophageal SCC in patients with HNSCC, and all cases of GC were observed to be early stage cancers in this study. Thorough endoscopic examination should be performed in patients with laryngeal cancer to de-

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Risk of second primary cancer among patients with head and neck cancers: a pooled analysis of 13 cancer registries

Cited by 97 publications

References 0 publications

Distinct Features of Second Primary Malignancies in Head and Neck Cancer Patients in Japan

Distinct Features of Second Primary Malignancies in Head and Neck Cancer Patients in Japan

Is a Preoperative Gastrointestinal Endoscopy for Second Primary Cancer Detection in Head and Neck Cancer Necessary? Ten-year Registry Data

Incidence of Gastric Cancer in Patients with Laryngeal Cancer

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