Risk of second primary malignancies following cutaneous melanoma diagnosis: A population-based study

Spanogle, Joshua P.; Clarke, Christina A.; Aroner, Sarah A.; Swetter, Susan M.

doi:10.1016/j.jaad.2009.07.039

Cited by 69 publications

(89 citation statements)

References 46 publications

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“…A limitation of these studies is that the follow-up period may not have adequately captured the latency period associated with MM. 34,35 So as not to underestimate the prevalence of neoplasms in the general population when comparing with the study population, we elected to use recent prevalence data rather than averaging across the study period. We reasoned that contemporary imaging techniques and diagnostic modalities are likely to have afforded improved detection and appropriate classification of neoplasms, particularly of uncommon neoplasms such as ocular melanoma.…”

Section: Discussionmentioning

confidence: 99%

Malignant Mesothelioma in Individuals With Nonmesothelial Neoplasms

Butnor¹,

Pavlisko²,

Sporn³

et al. 2018

Archives of Pathology &Amp; Laboratory Medicine

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Context.-Malignant mesothelioma (MM) is a component of the BAP1 tumor predisposition syndrome. Other than in BAP1 familial studies, nonmesothelial neoplasms in individuals with MM has not been comprehensively assessed.Objective.-To assess the spectrum and prevalence of nonmesothelial neoplasms in individuals with MM.Design.-Individuals with MM and second neoplasms were identified from a database of 3900 MM cases. The expected prevalence of each type of neoplasm was calculated and compared with the actual prevalence in the study population using available Surveillance, Epidemiology, and End Results data and other published data.Results.-Two hundred seventy nonmesothelial neoplasms were identified in 241 individuals (6% of the study population) with MM. Prostate adenocarcinoma was most common. Non-Hodgkin lymphoma, Hodgkin lymphoma, lung carcinoma, urothelial carcinoma, breast carcinoma, chronic lymphocytic leukemia, clear cell renal cell carcinoma, head and neck squamous cell carcinoma, papillary renal cell carcinoma, multiple myeloma/plasmacytoma, meningioma, pleomorphic undifferentiated sarcoma, chronic myelogenous leukemia, ocular melanoma, hepatocellular carcinoma, liposarcoma, and Wilms tumor all were more prevalent than expected.Conclusions.-Nonmesothelial neoplasms are uncommon in individuals with MM, but certain tumor types are increased in prevalence. In an unselected study population with respect to BAP1 status, the prevalence of several tumor types described in BAP1 mutation carriers, including lung carcinoma, clear cell renal cell carcinoma, breast carcinoma, meningioma, pleomorphic undifferentiated sarcoma, and ocular melanoma, was increased.( Although the frequency of second neoplasms in individuals with MM has been examined in the context of familial studies of BAP1 mutation carriers, the prevalence and types of second neoplasms among individuals with MM unselected with regard to BAP1 status are unknown.1 The purpose of this study is to comprehensively assess the spectrum and prevalence of nonmesothelial neoplasms in individuals with MM. DESIGNThis study was approved by the institutional review board at Duke University Medical Center, Durham, North Carolina. A database of one of the authors consisting of 3900 MM cases received for professional and medicolegal consultation from 1982 through 2016 was searched retrospectively for individuals with MM who also had a history of one or more antecedent or synchronous (ie, diagnosed during same hospital admission) nonmesothelial neoplasms. The expected prevalence of each type of nonmesothelial neoplasm was calculated based on the overall estimated prevalence reported by the Surveillance, Epidemiology, and End Results (SEER) program for 2013 and US Census Bureau population data from the same year. 4 As SEER data do not separate renal cancers by histologic type, the expected prevalence for all renal cancers was calculated and we extrapolated the expected prevalence of clear cell renal cell carcinoma and papillary renal cell carcinoma to be less than that of a...

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Section: Discussionmentioning

confidence: 99%

Malignant Mesothelioma in Individuals With Nonmesothelial Neoplasms

Butnor¹,

Pavlisko²,

Sporn³

et al. 2018

Archives of Pathology &Amp; Laboratory Medicine

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“…Among the ten studies, two reported RR, seven reported SIR, and one reported odds ratio (OR). A statistically significantly increased risk of TC after CM diagnosis with a risk ratio ranging from 1.75 to 3.6 was reported in all studies except for one in Denmark [5][6][7][8][10][11][12][13][14]. Four studies stratified risk by gender.…”

Section: Thyroid Cancer After Cutaneous Melanomamentioning

confidence: 94%

“…The majority were U.S. studies that utilized the cancer registry records from the Surveillance, Epidemiology, and End Results (SEER) database of the National Cancer Institute in North America, including a study that analyzed the Connecticut registry, which also contributes to the SEER database [5][6][7][8][9][10][11][12][13]. One population-based study was from Utah [14,15].…”

Section: Thyroid Cancer After Cutaneous Melanomamentioning

confidence: 99%

“…The non-U.S. studies included one from Denmark, one from Norway, and another that included thirteen population-based cancer registries from Europe, Canada, Australia, and Singapore [8,9,13]. Of the ten studies that analysed TC subsequent to CM diagnosis, six included subjects with primary invasive melanoma only, two included both invasive melanoma and melanoma in-situ (MIS), and the remainder did not specify CM type [5][6][7][8][9][10][11][12][13][14]. Most subjects were White, with a mean age at CM diagnosis ranging from 52 years to 54 years.…”

Section: Thyroid Cancer After Cutaneous Melanomamentioning

confidence: 99%

“…Similarly, in studies that stratified risk by age of CM diagnosis, no differences were found [6,7,9]. In studies that stratified risk of TC by time since primary CM diagnosis, mixed results were observed: three studies reported significantly increased risk of TC within five years following CM diagnosis, one study reported increased TC risk 5 to 9 years after CM diagnosis, and three studies reported an increased risk throughout [5][6][7][8][10][11][12]. One study stratified risk of TC by gender and CM invasiveness [12].…”

Section: Thyroid Cancer After Cutaneous Melanomamentioning

confidence: 99%

See 2 more Smart Citations

Meta-Analyses of Epidemiologic Associations between Cutaneous Melanoma and Thyroid Cancer

Tran¹,

Gotow²,

Galvin³

et al. 2016

J Clin Exp Dermatol Res

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Risk and Survival of Cutaneous Melanoma Diagnosed Subsequent to a Previous Cancer

et al. 2011

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To understand the risk of cutaneous melanoma (CM) following a previous cancer.Design: Using the Surveillance, Epidemiology, and End Results database (1988)(1989)(1990)(1991)(1992)(1993)(1994)(1995)(1996)(1997)(1998)(1999)(2000)(2001)(2002)(2003)(2004)(2005)(2006)(2007), we compared a cohort of patients diagnosed as having CM as a first cancer with a cohort of patients diagnosed as having CM following a previous cancer.Participants : We included 70 819 patients with CM as a first primary cancer and 6353 patients with CM following a previous cancer. Main Outcome Measures:We calculated the relative risk (RR) for development of primary CM following a previous cancer and used Cox modeling to examine survival characteristics of the 2 cohorts.Results: Patients younger than 45 years at first cancer diagnosis had significantly higher risk of CM following

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Risk of second primary malignancies following cutaneous melanoma diagnosis: A population-based study

Cited by 69 publications

References 46 publications

Malignant Mesothelioma in Individuals With Nonmesothelial Neoplasms

Malignant Mesothelioma in Individuals With Nonmesothelial Neoplasms

Meta-Analyses of Epidemiologic Associations between Cutaneous Melanoma and Thyroid Cancer

Risk and Survival of Cutaneous Melanoma Diagnosed Subsequent to a Previous Cancer

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