Risk of Sepsis and Mortality Among Patients With Chronic Obstructive Pulmonary Disease Treated With Angiotensin-Converting Enzyme Inhibitors or Angiotensin Receptor Blockers

Lai, Chih‐Cheng; Wang, Yahui; Chen, Ming-Fong; Wang, Hao-Chien; Yu, Chong‐Jen; Chen, Likwang

doi:10.1097/ccm.0000000000003475

Cited by 13 publications

(9 citation statements)

References 30 publications

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“…The secondary outcome was all-cause mortality. Moreover, the source of infection, and organ dysfunction were recorded as previous reported, [23] Sepsis patients received sympathomimetic or vasopressin were defined as septic shock.…”

Section: Methodsmentioning

confidence: 99%

Risk of sepsis among patients with COPD treated with fixed combinations of inhaled corticosteroids and long-acting Beta2 agonists

Chen

Lin

Wang

et al. 2019

Aging

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This study aimed to compare the effect of budesonide/formoterol and fluticasone/salmeterol on the risk and outcomes of sepsis in COPD patients. We conducted this study using the Taiwan National Health Insurance Research Database. We included COPD patients prescribed with budesonide/formoterol or fluticasone/salmeterol between 2004 and 2011. Outcomes including sepsis and mortality were measured. 10,267 COPD patients who received fluticasone/salmeterol and 6,844 patients who received budesonide/formoterol were enrolled into this study and then subsequence were adjusted by propensity score weighting. The incidence of sepsis was 5.74 and 4.99 per 100 person-years for the patients receiving fluticasone/salmeterol and budesonide/formoterol, respectively. Fluticasone/salmeterol was associated with higher risk of sepsis (aHR, 1.15; 95%CI, 1.07-1.24) and septic shock (aHR, 1.14; 95%CI, 1.01-1.29) than budesonide/formoterol. Besides, fluticasone/salmeterol was associated with higher risk of death (aHR, 1.090; 95%CI, 1.01-1.18) than budesonide/formoterol. Patients receiving fluticasone/salmeterol had a significant higher risk of sepsis related respiratory organ dysfunction, lower respiratory tract infection, genitourinary tract infection, bacteremia and skin infection. In conclusion, long-term treatment with budesonide/formoterol was associated with lower rates of sepsis and deaths than fluticasone/salmeterol in patients with COPD.

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Section: Methodsmentioning

confidence: 99%

Risk of sepsis among patients with COPD treated with fixed combinations of inhaled corticosteroids and long-acting Beta2 agonists

Chen

Lin

Wang

et al. 2019

Aging

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“…1. A total of 118 potentially relevant records were reviewed, of which six articles, which included 49,799 cases that met the inclusion criteria were included in the meta-analysis [15][16][17][18][19][20] (Table 1). A total of 112 studies were subsequently excluded because they used a combined intervention, were duplicated reports, or were of relatively low quality.…”

Section: Resultsmentioning

confidence: 99%

The impact of angiotensin-converting enzyme inhibitors or angiotensin receptor blockers on the mortality in sepsis: A systematic review and meta-analysis

Yu¹,

Huang²,

Zhang³

et al. 2020

Preprint

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Background The effect of angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs) on the mortality of patients with sepsis is not well characterized. The aim of this study was to elucidate the association between prior ACEI or ARB exposure and mortality in sepsis. Methods The PubMed, Embase, Web of Science, and Cochrane Library databases were searched for all studies of premorbid ACEI or ARB use and sepsis mortality until November 30 2019. Two reviewers independently assessed, selected, and abstracted data from studies reporting ACEIs or ARBs, sepsis, and mortality. The primary extracted data consisted of premorbid ACEI or ARB exposure, mortality, and general patient data. Two reviewers independently assessed the risk of bias and quality of evidence. Results A total of six studies comprising 281,238 patients with sepsis, including 49,799 cases with premorbid ACEI or ARB exposure were eligible for analysis. Premorbid ACEIs or ARBs exposure decreased the 30-day mortality in patients with sepsis. Moreover, the use of ACEIs or ARBs was associated with approximately a 6% decreased risk of 30-day mortality. Conclusions The results of this systematic review suggest that ACEI or ARB exposure prior to sepsis may be associated with reduced mortality. Further high-quality cohort studies and molecular mechanism experiments are required to confirm our results.

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“…Asthma has high correlation with obesity [25] and smoke [26]. The risk of sepsis and death in patients having COPD is presented by literature [27,28].…”

Section: Discussionmentioning

confidence: 99%

Respiratory Disorders: Physiology and Patient Problems

Santos-Filho¹

2018

Anat Physiol

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Respiratory disorders are worldwide studied. The aim of this study was to verify in scientific publications founded in PubMed database the disorders more common that affected the respiratory system and to evaluate the problems concerning to the patients. The methodology was using the words "respiratory disorders", patient, problems, in the PubMed to find the publications that treat these words. We founded 3620 publications of "respiratory disorders", 1422 were associated with patient, 94 publications were associated with the last research with problems. It was founded that out of 38 publications in last ten years 28 were associated with humans. The prevalence of respiratory disorders, like breathing and asthma problems, due to the difficulties faced by patients, were co-related with obesity and smoke mainly.

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Risk of Sepsis and Mortality Among Patients With Chronic Obstructive Pulmonary Disease Treated With Angiotensin-Converting Enzyme Inhibitors or Angiotensin Receptor Blockers

Cited by 13 publications

References 30 publications

Risk of sepsis among patients with COPD treated with fixed combinations of inhaled corticosteroids and long-acting Beta2 agonists

Risk of sepsis among patients with COPD treated with fixed combinations of inhaled corticosteroids and long-acting Beta2 agonists

The impact of angiotensin-converting enzyme inhibitors or angiotensin receptor blockers on the mortality in sepsis: A systematic review and meta-analysis

Respiratory Disorders: Physiology and Patient Problems

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