Risk of spontaneous abortion in singleton and twin pregnancies after IVF/ICSI

Tummers, Philippe; Sutter, Petra De; Dhont, Marc

doi:10.1093/humrep/deg308

Cited by 150 publications

(94 citation statements)

References 23 publications

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“…Although our findings corroborate other observations in pregnancies following assisted reproduction (3,4), it is unknown whether they represent the situation in spontaneous conception. It is also unknown if the advantage of twins remains the same in various regimens of hormonal support used in IVF protocols, or when transfers are performed at the blastocyst stage or of frozen-thawed embryos.…”

Section: Discussionsupporting

confidence: 86%

“…This paper focused on potential explanations for the relatively recent observation in pregnancies following IVF/ICSI, that twins carry a lower risk of embryonic loss compared with singletons (3)(4)(5). In a typical IVF program, few embryos are selected for transfer, and the surplus embryos are frozen, donated, or discarded.…”

Section: Discussionmentioning

confidence: 99%

“…Our recent study (5) fully supports these observations, and, in addition, shows that this is also the case for triplet and quadruplet gestations. One may argue that the increased loss of singletons in the abovementioned studies (3)(4)(5) represents an excessive loss rate reported from these centers only. However, similar loss rates of singletons following IVF were reported in other series (6,7).…”

Section: Introductionmentioning

confidence: 97%

“…Most texts on multiple gestations would submit to an increased embryonic loss among twin gestations compared to singletons. However, an intriguing finding of a recent comparative study indicates that pregnancy loss occurred in 5.1% of the in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) twin pregnancies compared to 21.1% in singletons (3). The authors maintained that the embryological potential for successful development is not the same for twins and singletons and that twin pregnancies after IVF/ICSI have a better survival potential than singletons.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Lower embryonic loss rates among twin gestations following assisted reproduction

Sala¹,

Nucera²,

Gallinelli³

et al. 2005

J Assist Reprod Genet

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Purpose : To determine whether maternal age and number of transferred embryos influence early pregnancy losses in twin pregnancies compared to singletons following IVF/ICSI. Methods : We compared the pregnancy loss rates in singleton (n = 549) and twin (n = 252) gestations, stratified by maternal age (≤35 and >35 years) and the number of transferred embryos (1-3 and 4-9). Results : Loss rates of singleton pregnancies were significantly higher than that in twins (OR 3.0, 95% CI 1.9, 4.9), especially among singletons conceived after transfer of 4-9 embryos (OR 5.0, 95% CI 2.2, 11.9). Younger mothers of twins had lower loss rates (OR 0.3, 95% CI 0.1, 0.9). Conclusion : Twins have a significantly reduced spontaneous miscarriage rate compared with singletons following IVF/ICSI. Higher implantation rates per cycle (i.e., development of twins rather than one live embryo) may represent a better capacity of the uterus for early embryonic development.

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Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Lower embryonic loss rates among twin gestations following assisted reproduction

Sala¹,

Nucera²,

Gallinelli³

et al. 2005

J Assist Reprod Genet

View full text Add to dashboard Cite

show abstract

“…It is estimated that the incidence of spontaneous abortions is between 10 and 20 % among clinically recognized pregnancies [3]. Though there are numerous factors such as anatomical defects, endocrinological, immunological and genetic factors which can lead to iRPL but the exact cause is not known in majority of cases and such cases are classified as idiopathic recurrent pregnancy loss (iRPL) [2].…”

Section: Introductionmentioning

confidence: 99%

Analysis of telomere length in couples experiencing idiopathic recurrent pregnancy loss

Thilagavathi

Mishra

Kumar

et al. 2013

J Assist Reprod Genet

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Purpose Telomere length plays a significant role in various disorders; however, its role in idiopathic recurrent pregnancy loss (iRPL) is not known. The objective of this study was to assess telomere length in peripheral blood leukocytes in couples experiencing unexplained recurrent pregnancy loss (iRPL). Methods The study included 25 couples experiencing iRPL and 20 controls. The mean relative telomere length was measured by quantitative Real Time PCR (Q-PCR) based assay, which measures the average ratio of telomere repeat copy number to a single copy gene (36B4) copy number (T/S ratio) in each sample. Results The relative leukocyte mean telomere length (T/S) in both men and women from iRPL group was significantly lower (p<0.05) when compared to controls. A significant (P<0.05) negative correlation was found between age and leukocyte telomere length (T/S ratio). Among the sperm parameters seminal volume was found to be negatively (r = −0.4679) associated with the telomere T/S ratio. The DNA fragmentation index of sperm showed positive correlation (r=0.4744) with telomere length. In this preliminary study, we found that shorter telomere length in both men and women may be associated with early pregnancy loss. Conclusion In conclusion, shorter telomere length in both male and female partners appears to play a role in the idiopathic recurrent pregnancy loss. Loss of telomeric DNA due to oxidative stress needs further analysis. Analysis of telomere length in germ cells are needed to further substantiate the findings of this study.

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Familial twinning and fertility in Dutch mothers of twins

Hoekstra

Willemsen

Beijsterveldt

et al. 2008

American J of Med Genetics Pt A

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We studied twinning and fertility indices in mothers with spontaneous monozygotic (MZ) and dizygotic (DZ) twins and in mothers who conceived their twins after the use of assisted reproduction techniques (ART). Participants in this study consisted of 8,222 and 5,505 women with spontaneous DZ and MZ offspring and 4,164 and 250 women with ART DZ and MZ twin pairs, respectively. Women were compared with respect to the number of sibs and offspring, the presence of other relatives with twins and the time it took to conceive the twins. We also compared familial twinning between a younger and an older age group.Women with spontaneous DZ twins more often reported female relatives with twins than those with spontaneous MZ twins. The proportion of DZ versus MZ twin offspring in relatives was also larger in women with spontaneous DZ offspring than in women with MZ offspring. The first group of women reported a shorter time to conceive. Women with ART twins had fewer sibs and offspring and less often reported relatives with twins. We did not observe that DZ twinning was more familial in women who had their twins before age 36 years compared to older women.Familial DZ twinning is clearly present in mothers of spontaneous DZ twins. The mechanisms underlying spontaneous and non-spontaneous DZ twinning are different and fertility treatment should be taken into account in any study of twinning. Twinning is not more familial in women who have their twins at a younger age.

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Risk of spontaneous abortion in singleton and twin pregnancies after IVF/ICSI

Abstract: Our data give an estimate of the probability of miscarriage or fetal demise at any given period of the first trimester both for singleton and twin pregnancies. Twin pregnancies after IVF have a better potential for survival than singleton pregnancies.

Cited by 150 publications

References 23 publications

Lower embryonic loss rates among twin gestations following assisted reproduction

Lower embryonic loss rates among twin gestations following assisted reproduction

Analysis of telomere length in couples experiencing idiopathic recurrent pregnancy loss

Familial twinning and fertility in Dutch mothers of twins

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