Risk of Subsequent Dementia Among Patients With Bipolar Disorder or Major Depression: A Nationwide Longitudinal Study in Taiwan

Chen, Mu Hong; Li, Cheng Ta; Tsai, Chia Fen; Lin, Wei Chen; Chang, Wen Han; Chen, Tzeng Ji; Pan, Tai‐Long; Su, Tung Ping; Bai, Ya Mei

doi:10.1016/j.jamda.2015.01.084

Cited by 54 publications

(28 citation statements)

References 46 publications

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“…For the SCIP, it may be advisable to use a somewhat more conservative cut‐off (ie, lower SCIP total score) for cognitive impairment in older patients than the published norm material given the age‐related cognitive decline, which is potentially accelerated in mood disorders . Further, BD in older age is associated with a greater prevalence of dementia compared with the general population . An international expert group within the ISBD therefore recently recommended that clinicians screen cognition in older patients using dementia‐sensitive instruments, such as the Mini Mental State Examination (MMSE) or Montreal Cognitive Assessment (MoCA) .…”

Section: Results: Task Force Recommendationsmentioning

confidence: 99%

Assessing and addressing cognitive impairment in bipolar disorder: the International Society for Bipolar Disorders Targeting Cognition Task Force recommendations for clinicians

et al. 2018

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Section: Results: Task Force Recommendationsmentioning

confidence: 99%

Assessing and addressing cognitive impairment in bipolar disorder: the International Society for Bipolar Disorders Targeting Cognition Task Force recommendations for clinicians

et al. 2018

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“…Relevantly, there are case reports suggesting that early stage neurodegenerative disease can mimic psychosis and BD, such that a late manifestation of BD and associated cognitive impairment may represent a putative prodrome marker from which dementia or Alzheimer's Disease may emerge . Nonetheless, BD patients appear to be at an increased risk of developing pre‐senile and senile dementia compared to those with other psychiatric or medical conditions as well as the general population, irrespective of onset age . A register‐based study of >4200 patients with BD revealed that the long‐term risk of dementia increases with the number of manic and depressive mood episodes, with a 6% increased risk for every new episode .…”

Section: Trajectory Of Cognitive Functioning In Bdmentioning

confidence: 99%

“…[52][53][54] Nonetheless, BD patients appear to be at an increased risk of developing pre-senile and senile dementia compared to those with other psychiatric or medical conditions as well as the general population, irrespective of onset age. [55][56][57][58][59] A register-based study of >4200 patients with BD revealed that the long-term risk of dementia increases with the number of manic and depressive mood episodes, with a 6% increased risk for every new episode. 60 Thus, it remains unclear whether those that go on to develop dementia are showing progressive impairment as a result of mood episodes or are simply manifesting a more severe BD phenotype associated with a higher risk for dementia.…”

Section: Nonetheless It Should Be Noted That Relatively Limited Follmentioning

confidence: 99%

Current understandings of the trajectory and emerging correlates of cognitive impairment in bipolar disorder: An overview of evidence

et al. 2019

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Objectives Cognitive dysfunction affects a significant proportion of people with bipolar disorder (BD), but the cause, trajectory and correlates of such dysfunction remains unclear. Increased understanding of these factors is required to progress treatment development for this symptom dimension. Methods This paper provides a critical overview of the literature concerning the trajectories and emerging correlates of cognitive functioning in BD. It is a narrative review in which we provide a qualitative synthesis of current evidence concerning clinical, molecular, neural and lifestyle correlates of cognitive impairment in BD across the lifespan (in premorbid, prodromal, early onset, post‐onset, elderly cohorts). Results There is emerging evidence of empirical links between cognitive impairment and an increased inflammatory state, brain structural abnormalities and reduced neuroprotection in BD. However, evidence regarding the progressive nature of cognitive impairment is mixed, since consensus between different cross‐sectional data is lacking and does not align to the outcomes of the limited longitudinal studies available. Increased recognition of cognitive heterogeneity in BD may help to explain some inconsistencies in the extant literature. Conclusions Large, longitudinally focussed studies of cognition and its covariation alongside biological and lifestyle factors are required to better define cognitive trajectories in BD, and eventually pave the way for the application of a precision medicine approach for individual patients in clinical practice.

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“…Between 2011 and 2012, 130,000 people or 4.97% of those aged 65 years and over in Taiwan had dementia [2]. Diseases including diabetes mellitus [3,4,5], hypertension [6,7], hyperlipidemia [8], obesity [9,10], depression [11,12], traumatic brain injury [13,14], stroke [15,16], and chronic kidney disease [17,18] have been associated with an increased risk of dementia in previous studies.…”

Section: Introductionmentioning

confidence: 99%

Are Chronic Periodontitis and Gingivitis Associated with Dementia? A Nationwide, Retrospective, Matched-Cohort Study in Taiwan

et al. 2016

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Background: Chronic periodontitis and gingivitis are associated with various diseases; however, their impact on dementia is yet to be elucidated. This study is aimed at investigating the association between chronic periodontitis and gingivitis, and the risk of developing dementia. Methods: A total of 2,207 patients, with newly diagnosed chronic periodontitis and gingivitis between January 1, 2000 and December 31, 2000, were selected from the National Health Insurance Research Database of Taiwan, along with 6,621 controls matched for sex and age. After adjusting for confounding factors, Cox proportional hazards analysis was used to compare the risk of developing dementia during the 10-year follow-up period. Results: Of the study subjects, 25 (1.13%) developed dementia compared to 61 (0.92%) in the control group. Cox proportional hazards regression analysis revealed that the study subjects were more likely to develop dementia (hazard ratio (HR) 2.085, 95% CI 1.552-4.156, p < 0.001). After adjusting for sex, age, monthly income, urbanization level, geographic region, and comorbidities, the HR for dementia was 2.54 (95% CI 1.297-3.352, p = 0.002). Conclusions: Patients with chronic periodontitis and gingivitis have a higher risk of developing dementia. However, further studies on other large or national data sets are required to support the current findings.

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Risk of Subsequent Dementia Among Patients With Bipolar Disorder or Major Depression: A Nationwide Longitudinal Study in Taiwan

Cited by 54 publications

References 46 publications

Assessing and addressing cognitive impairment in bipolar disorder: the International Society for Bipolar Disorders Targeting Cognition Task Force recommendations for clinicians

Assessing and addressing cognitive impairment in bipolar disorder: the International Society for Bipolar Disorders Targeting Cognition Task Force recommendations for clinicians

Current understandings of the trajectory and emerging correlates of cognitive impairment in bipolar disorder: An overview of evidence

Are Chronic Periodontitis and Gingivitis Associated with Dementia? A Nationwide, Retrospective, Matched-Cohort Study in Taiwan

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