Risk of Symptom Recurrence With Medication Discontinuation in First-Episode Psychosis: A Systematic Review

Effectiveness of Social Skills Training Program on Social Functioning and Severity of Symptoms Among Patients with Schizophrenia

“…It also noticed that, the current findings mentioned majority of the study subjects were not adhere to medication and didn't follow up psychiatrist this finding was similar to a study by [33], [35] who found that, non-adherence to medication can ranged from patients who refuse to take prescribed medications due to lack of acceptance of the need for medication, to patients who perceive the need for medications and are committed to treatment but are nonadherent to medication due to forgetfulness or financial constraints, also Lack of family support for adherence, or having no family, further contributes to non-adherence to medications Furthermore, a study done by [36], [37] emphasized that, non-adherence to medications during the first week after discharge from an inpatient hospitalization was associated with a high risk for re-hospitalization within one month of discharge. Length of hospital stay is also extended due to non-adherence.…”

Risk Factors Associated With Readmissions of Hospitalized Mentally Ill Patients

“…Length of hospital stay is also extended due to non-adherence. [28,29 ]found that, an average hospital costs in non-adherent inpatients were three times higher than costs for adherent inpatients, although pharmacy costs were higher among adherent compared to non-adherent inpatients. In that sense, some studies related to success of treatment adherence with different levels of commitment related to the patients' role, their relation with health services-professionals and with the quality of care the professional delivers.…”

Inefficient Neural Self-Stabilization: A theory of spontaneous resolutions and recurrent relapses in psychosis

“…Relapses can occur even in adequately medicated patients (primary relapse) 36,37 ; but the rates of relapse are distinctly higher in those who discontinue treatment in the early stages of illness (interventional relapse) 38,39 . When relapses occur during the course of illness, irrespective of the duration of intervening period of recovery, the same predictable set of symptoms tend to recur with each episode 40,41 .…”

“…Furthermore, unlike the first episode of psychosis which is preceded by a long duration of prodromal symptoms and gradual buildup of unusual experiences, relapses often occur without a similar insidious prodrome 36 . With each relapse, treatment resistance becomes more likely, especially when the relapse occurs after antipsychotic discontinuation 36,39 . Notwithstanding this phenomenon, a small proportion of patients achieve good function, despite a high number of early relapses [42][43][44] .…”