Risk of synchronous endometrial disorders in women with endometrioid borderline tumors of the ovary

Jia, Shuang-Zheng; Zhang, Junji; Yang, Junjun; Xiang, Yang; Liang, Zhiyong; Leng, Jinhua

doi:10.1186/s13048-018-0405-0

Cited by 12 publications

(32 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 29 Another paper by Jia et al reported on 29 patients with eBOTs, half of them undergoing conservative surgery, followed up for a median of 54 months, experiencing a recurrence rate of 10.3% (3 patients). 27 Of these 3 patients with recurrences, all 3 were initially treated conservatively. 27 Finally, Yüksel et al described no recurrences in their study comprising 9 eBOTs in which 2 had undergone conservative surgery, over a follow-up period of 80–120 months.…”

Section: Discussion and Review Of Literaturementioning

confidence: 99%

<p>Ultraconservative, Fertility Sparing Treatment of Bilateral Borderline Ovarian Tumors: A Case Report of a 26-Year-Old, 0-Gravida with an Endometrioid Borderline Ovarian Tumor of the Right Ovary and a Sero-Mucinous Borderline Ovarian Tumor of the Left Ovary and a Review of the Literature</p>

Verta

Kipp

2020

IJWH

View full text Add to dashboard Cite

Endometrioid borderline ovarian tumors are rare, entailing a lack of data on their natural history as well as the safety of conservative and ultraconservative surgical management, especially in cases with bilateral borderline ovarian tumors including one of endometrioid differentiation. Therefore, we present such a case and provide a review of the literature on endometrioid borderline ovarian tumors. We report the case of a 26-year-old, 0-gravida with an endometrioid borderline ovarian tumor of the right and a sero-mucinous borderline ovarian tumor of the left ovary treated by fertility sparing, ultraconservative surgery with bilateral cystectomy, completed by staging procedures including omentectomy and peritoneal sampling, as well as endometrial sampling by means of curettage. Reviewing the literature and taking into account the course of our case, we propose the feasibility of an ultraconservative management, including endometrial sampling, in young patients with bilateral borderline ovarian tumors including one of endometrioid differentiation who desire to preserve fertility, followed by a closely monitored follow-up.

show abstract

Section: Discussion and Review Of Literaturementioning

confidence: 99%

<p>Ultraconservative, Fertility Sparing Treatment of Bilateral Borderline Ovarian Tumors: A Case Report of a 26-Year-Old, 0-Gravida with an Endometrioid Borderline Ovarian Tumor of the Right Ovary and a Sero-Mucinous Borderline Ovarian Tumor of the Left Ovary and a Review of the Literature</p>

Verta

Kipp

2020

IJWH

View full text Add to dashboard Cite

show abstract

“…2 ), resulting in their need to compromise the uterus and their fertility potential. Previous studies have demonstrated that 20–50% of EBOT patients have synchronous endometrial disorders, and a literature review has shown that among 111 EBOT patients with endometrial evaluations, 41.4% developed synchronous endometrial disorders [ 14 ]. Additionally, coexisting endometriosis was found in 40% ( n = 8/20) of the study patients and would also sacrifice their fecundity.…”

Section: Discussionmentioning

confidence: 99%

“…However, data on the safety of fertility preservation in endometrioid BOTs (EBOTs) are lacking, given its low incidence [ 12 – 14 ]. Previous studies on EBOTs have focused mainly on their pathological descriptions [ 13 , 15 – 17 ] and included only brief descriptions of the clinical features, management and follow-up of these patients [ 12 , 13 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

“…Previous studies on EBOTs have focused mainly on their pathological descriptions [ 13 , 15 – 17 ] and included only brief descriptions of the clinical features, management and follow-up of these patients [ 12 , 13 , 15 ]. About one-third of patients with EBOT have synchronous endometrial disorders [ 13 , 15 , 17 ] and concomitant endometriosis [ 12 , 13 , 16 – 18 ], and half of the patients with EBOTs are nulliparous [ 14 ]. However, the fertility outcomes after conservative surgery in these EBOTs patients are not known.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Safety and fertility outcomes after the conservative treatment of endometrioid borderline ovarian tumours

et al. 2018

Self Cite

View full text Add to dashboard Cite

BackgroundBecause of the rarity of endometrioid borderline ovarian tumours (EBOTs), there is a paucity of data concerning the natural history and prognosis of this condition. Thus, the objective of our study was to establish the feasibility of fertility preservation in young women with EBOTs, as well as their oncological and reproductive outcomes.MethodsConsecutive patients with EBOTs, treated at a tertiary referral centre during a span of 22 years, were retrospectively analysed. Recurrence-free interval, as well as its association with the type of surgery and with other clinical and pathological features, was assessed using the Kaplan-Meier and Cox proportional hazards methods.ResultsOf the 59 patients studied, the median follow-up time was 30 months (range, 6–177 months). Nine (15.3%) patients developed 13 recurrences 6–137 months after the initial surgeries, including three patients (5.1%; n = 3/59) who developed six invasive recurrences 8, 18 and 68 months after their initial surgeries. Conservative surgery showed a tendency towards a high recurrence rate (17.2% versus 13.3%); however, this difference was not significant (p = 0.45). The 5-year recurrence-free survival rate was significantly higher in the oophorectomy group than in the cystectomy group (p = 0.001). Cox regression analysis showed that none of the variables assessed were associated with an increased hazard ratio for recurrence, except for a younger age at diagnosis (p = 0.021). Of 20 patients who attempted to conceive, three pregnancies among two patients (10.0%) resulted in two live births.ConclusionsConservative surgery with unilateral adnexectomy can be proposed for young women with EBOTs with fertility desire; however, the reproductive result is not satisfactory. In addition, careful evaluations of the endometria should be offered during the initial surgery and follow-up period.Trial registrationRetrospectively registered.

show abstract

“…In fact presence of abnormal vascular bleeding in setting of endometrioid ovarian cancer suggests coexistent endometrial pathology as was the case in our patient. In one study [7], 10/11 (90.9%) of women with abnormal vaginal bleeding in setting of endometrioid ovarian tumor had coexistent pathology which is much higher than that of general population (1.3% of premenopausal [8] and 17.1% of menopausal women [9] with abnormal vaginal bleeding harbor endometrial cancer or atypical hyperplasia). In fact women with abnormal vaginal bleeding may be detected and treated as they seek medical help earlier.…”

Section: Discussionmentioning

confidence: 99%

Fertility Preserving Surgery in A Woman with Synchronous Endometrial and Ovarian Cancer Followed by Successful Pregnancy Outcome: Case Report and Review of Literature

Suri

Bansal

Aggarwal

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Successful pregnancy outcome in women with synchronous ovarian and endometrial cancers is very rare. We report successful pregnancy outcome in a young woman managed conservatively for synchronous endometrial and ovarian cancer. Case presentation: 30 years old nulliparous lady presented following exploratory laparotomy, left salpingo-oophorectomy and hysteroscopic polypectomy for left adnexal mass. Histology revealed endometrioid carcinoma of left ovary and moderately differentiated adenocarcinoma in the resected polyp. She underwent staging laparotomy along with hysteroscopy which confirmed above findings without any evidence of further tumor spread. She was treated conservatively with high dose oral progestin (megestrol acetate, 160mg) and leuprolide acetate 3.75mg monthly injections for three months along with four cycles of carboplatin and paclitaxel based chemotherapy followed by monthly injection of leuprolide for further three months. After failure of spontaneous conception, she underwent ovulation induction for six cycles along with intrauterine insemination which failed. She underwent in vitro fertilization with donor egg followed by elective cesarean section at 37weeks of gestation. She delivered a healthy baby of weight 2.7 Kg. Intraoperatively 5×6cm right ovarian cyst was found which drained chocolate coloured fluid on puncture and cystectomy was carried out. Histological examination revealed endometrioid cyst of right ovary. Uterus was spared as she wanted to preserve her fertility. She is being followed periodically and is normal nine months following delivery. She is on injection Depot medroxy progesterone acetate once every three months.

show abstract

Risk of synchronous endometrial disorders in women with endometrioid borderline tumors of the ovary

Cited by 12 publications

References 27 publications

<p>Ultraconservative, Fertility Sparing Treatment of Bilateral Borderline Ovarian Tumors: A Case Report of a 26-Year-Old, 0-Gravida with an Endometrioid Borderline Ovarian Tumor of the Right Ovary and a Sero-Mucinous Borderline Ovarian Tumor of the Left Ovary and a Review of the Literature</p>

<p>Ultraconservative, Fertility Sparing Treatment of Bilateral Borderline Ovarian Tumors: A Case Report of a 26-Year-Old, 0-Gravida with an Endometrioid Borderline Ovarian Tumor of the Right Ovary and a Sero-Mucinous Borderline Ovarian Tumor of the Left Ovary and a Review of the Literature</p>

Safety and fertility outcomes after the conservative treatment of endometrioid borderline ovarian tumours

Fertility Preserving Surgery in A Woman with Synchronous Endometrial and Ovarian Cancer Followed by Successful Pregnancy Outcome: Case Report and Review of Literature

Contact Info

Product

Resources

About