Risk of Thyroid Disorders in Patients with Gout and Hyperuricemia

Xu, Jianhua; Wang, Bin; Li, Qian; Yao, Qiuming; Jia, Xi; Song, Ronghua; Zhang, Jinan

doi:10.1055/a-0923-9184

Cited by 9 publications

(7 citation statements)

References 48 publications

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“…In some studies, both hypothyroidism and hyperthyroidism seem to increase the risk for hyperuricemia, and significantly more so among males than among females [46,47]. In other studies, hypothyroidism and hyperthyroidism were strongly associated with gout but showed weak [48] or no [49] association with hyperuricemia. More studies are warranted to elucidate the influence of gout and hyperuricemia on TD.…”

Section: Hyperuricemia and Yroid Functionmentioning

confidence: 96%

Thyroid Dysfunction and Dysmetabolic Syndrome: The Need for Enhanced Thyrovigilance Strategies

Kalra

Aggarwal²,

Khandelwal

2021

International Journal of Endocrinology

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Thyroid dysfunction (TD) is common in metabolic disorders such as diabetes mellitus (DM), cardiovascular disease (CVD), obesity, dyslipidemia, hyperuricemia, kidney and liver dysfunctions, and polycystic ovary syndrome (PCOS). Subclinical hypothyroidism (SHypo) worsens glycemic control in patients with DM, and these patients, especially those with Type-1DM, have higher prevalence of TD. Both TD and DM increase CVD risk. Even minor alteration in thyroid hormone (TH) levels can alter cardiovascular function. While hyperthyroidism increases systolic blood pressure and leads to high-output heart failure, hypothyroidism increases diastolic blood pressure and leads to low-output heart failure. Chronic subclinical hyperthyroidism (SHyper) and SHypo both increase the risk of hypertension, coronary artery disease (CAD) events, CAD deaths, and total deaths. SHyper alters cardiac morphology and function. SHypo causes dyslipidemia and endothelial dysfunction and increases the risk for weight gain and obesity. Overweight and obese patients often have hyperleptinemia, which increases the secretion of thyroid stimulating hormone (TSH) and induces TD. Dyslipidemia associated with TD can increase serum uric acid levels. Hyperuricemia promotes inflammation and may increase the risk for dyslipidemia, atherosclerosis, and CVD. TD increases the risk for developing chronic kidney disease. In nephrotic syndrome, proteinuria is associated with urinary loss of TH leading to TD. Some correlation between TD and severity of liver disease is also seen. TD and PCOS have common risk factors and pathophysiological abnormalities. Hypothyroidism must be excluded before diagnosing PCOS. Current guidelines do not strongly recommend thyroid screening in the presence of all metabolic disorders. However, pragmatic thyrovigilance is required. Clinicians must stay alert to signs and symptoms of TD, maintain high clinical suspicion, and investigate thoroughly. Drug-induced TD should be considered when TH levels do not match clinical findings or when patients are on medications that can alter thyroid function.

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Section: Hyperuricemia and Yroid Functionmentioning

confidence: 96%

Thyroid Dysfunction and Dysmetabolic Syndrome: The Need for Enhanced Thyrovigilance Strategies

Kalra

Aggarwal²,

Khandelwal

2021

International Journal of Endocrinology

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“…The presence of gout history has been suggested to elevate the risk of thyroid diseases in prior studies. In a cross-sectional study, female patients with gout demonstrated higher odds of hypothyroidism (OR = 2.44, 95% CI = 1.15–5.17) and Hashimoto’s thyroiditis (OR = 3.15, 95% CI = 1.53–6.49) [ 10 ]. Hyperthyroidism was associated with increased odds for gout in both males (OR = 1.37, 95% CI = 1.10–1.69) and females (OR = 2.13, 95% CI = 1.58–2.87) [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

“…In addition to inflammatory conditions, gout is related to metabolic derangements such as metabolic syndrome [ 9 ]. Furthermore, a few prior studies have suggested a relationship between gout and thyroid abnormalities, with a few conflicting results [ 10 ]. Thyroid cancer is associated with benign thyroid diseases, including hyperthyroidism, thyroiditis, and autoimmune thyroid diseases [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Gout on Thyroid Cancer Incidence: A Nested Case-Control Study Using a National Health Screening Cohort

Kim

Yoo

Kwon

et al. 2022

JPM

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In this study, we investigated the risk of thyroid cancer in patients with gout. Participants ≥ 40 years old in the Korean National Health Insurance Service–Health Screening Cohort were investigated. A total of 5844 patients with thyroid cancer were paired with 23,376 comparison participants (no history of thyroid cancer) to build the nested case–control study. A previous history of gout was collected from both the thyroid cancer and comparison participants. The relationship of thyroid cancer with a prior history of gout was analyzed using a conditional logistic regression model. The rate of gout was higher in the patients with thyroid cancer than in the comparison group. In the total study population, the relationship of thyroid cancer with a prior history of gout was not statistically evident. A previous history of gout was related to an increased risk of gout in the < 60 years old, normal weight, abnormal blood pressure, and CCI score = 0 groups. The occurrence of thyroid cancer was not associated with a prior history of gout in the general adult population. However, a prior history of gout was related to an elevated risk of thyroid cancer in middle-aged and healthy populations without comorbidities.

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“…Hence, any disruption in renal function or metabolic processes may potentially influence alterations in uric acid levels. The available research on the relationship between hyperuricemia and hyperthyroidism is still limited despite the potential linkages that have been proposed (Xu et al, 2019). Researchers have investigated the probable association between these two phenomena in recent studies, which might be significant for comprehending metabolic deregulation and enhancing treatment strategies.…”

Section: Introductionmentioning

confidence: 99%

The Potential Correlation Between Hyperuricemia and Hyperthyroidism Is Being Examined

KHAN,

BASIT

et al. 2023

Biol Clin Sci Res J

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Hyperuricemia is characterized by high levels of uric acid in the bloodstream, while hyperthyroidism refers to excessive thyroid gland activity. Both conditions can significantly affect a patient's quality of life. This study aimed to comprehensively analyze a sample size of 100 patients at MTI LRH, Peshawar, to address the research gap in this area. The study employed a prospective design, which involved collecting patient data over time. The study was conducted at the Department of Medicine, Medical Teaching Institution Lady Reading Hospital (MTI LRH), Peshawar, from January to July 2021. One hundred patients were chosen randomly from those who presented at MTI LRH during the study period. The inclusion criteria were individuals 18 or older who had documented thyroid function test results and had blood uric acid levels on record. The study participants included 50 males and 50 females, with a median age of 41. Most participants (55%) were between the ages of 31 and 50, with 25% in the 31-40 age group and 30% in the 41-50 age group. The remaining 45% were younger than 30 or older than 50. The data showed a slight negative correlation (r = -0.15) between TSH and uric acid levels, indicating that as TSH levels decreased, uric acid levels increased. However, this correlation was not statistically significant (p=0.20). The study found no significant correlation between thyroid function and uric acid levels in the sample population. Although there have been inconsistencies in previous literature on this topic, our results were consistent with past investigations.

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Risk of Thyroid Disorders in Patients with Gout and Hyperuricemia

Cited by 9 publications

References 48 publications

Thyroid Dysfunction and Dysmetabolic Syndrome: The Need for Enhanced Thyrovigilance Strategies

Thyroid Dysfunction and Dysmetabolic Syndrome: The Need for Enhanced Thyrovigilance Strategies

The Effect of Gout on Thyroid Cancer Incidence: A Nested Case-Control Study Using a National Health Screening Cohort

The Potential Correlation Between Hyperuricemia and Hyperthyroidism Is Being Examined

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