Risk of transition to schizophrenia following first admission with substance-induced psychotic disorder: a population-based longitudinal cohort study

Abstract

Risk of transition to schizophrenia following first admission with substance-induced psychotic disorder: a population-based longitudinal cohort study.

A Comparison of Methamphetamine-Induced Psychosis and Schizophrenia: A Review of Positive, Negative, and Cognitive Symptomatology

“…Indeed, a Thai study of METH abusers, who were initially hospitalized for METH psychosis found that 38.8% had been diagnosed with schizophrenia due to persistent psychosis at 5 years follow up ( 91 ), and 5.0% of Chinese patients with METH-induced psychosis had their diagnosis changed to schizophrenia ( 49 ). Longitudinal analyses have also found that 19.1% ( 92 ) to 30% ( 93 ) of patients initially admitted for amphetamine-induced psychosis had transitioned to a schizophrenia diagnosis at follow-up. Furthermore, a large study conducted over a 10 year period in the USA determined that individuals who were hospitalized for METH-related causes had a higher risk of receiving a subsequent schizophrenia diagnosis ( 94 ).…”

Escalating patterns of emergency health care prior to first admission with amphetamine psychosis: A window of opportunity?

“…A brief amphetamine-related psychosis of sufficient severity to require hospital admission may be a first step towards developing a more enduring psychotic disorder. Estimates of the rate of progression from drug-induced psychosis to a later diagnosis of Schizophrenia range from 17% to 46% (Alderson et al, 2017;Niemi-Pynttari et al, 2013;Sara et al, 2014). Young adults admitted to hospital with any methamphetamine-related condition have a 10-fold increased risk of later development of Schizophrenia compared with matched controls admitted with appendicitis (Callaghan et al, 2012).…”

Increased risk of hospital admission for ICD‐9‐CM psychotic episodes following admission for epilepsy

“…6,7 In addition, several substances of abuse such as methamphetamine 8 and synthetic cannabinoids 9 can cause a wide variety of neurologic symptoms including seizures and acute psychosis, and are ultimately associated with an increased long-term risk of transition to schizophrenia. 10 Although strong associations between epilepsy and psychosis have been found in previous studies, the risk of severe psychosis (related to schizophrenia or otherwise) after hospitalization for epilepsy is unclear. A hospital admission is a particularly vulnerable time for epilepsy patients, and the intermediate-term risk of psychiatric readmission for psychosis after discharge from a hospitalization for epilepsy has not, to our knowledge, been studied directly.…”

“…Because there can be no qualitative difference between psychosis related to schizophrenia and interictal and postictal psychotic states, it has been suggested previously that the true coincidence of schizophrenia and epilepsy may be less frequent than is commonly thought . In addition, several substances of abuse such as methamphetamine and synthetic cannabinoids can cause a wide variety of neurologic symptoms including seizures and acute psychosis, and are ultimately associated with an increased long‐term risk of transition to schizophrenia …”