Risk of tuberculosis in low birth weight children from East Romania

Abstract

Introduction: In the context of the global tuberculosis (TB) burden, children represent 10% of all cases, with high incidence rates still reported by many regions worldwide. The study aim was to determine whether there is a correlation between TB clinical diagnosis and low birth weight in children at various ages. Material and methods: The study was conducted between 2010 and 2014, on a group of 1783 pediatric patients and a subgroup of 137 pediatric patients with low birth weight (LBW). Data were collected from patients' records and hospital statistical reports then processed using MS Excel 2010 and SPSS v.22. Results: The subgroup of LBW patients accounted for 7.68% of all recorded cases. Girls were predominant (total M: F = 0.95; LBW group M: F = 0.91, p < 0.05), most from an urban area (total U: R = 1.29; LBW subgroup U: R = 1.36, p < 0.05). 22.59% of LBW subgroup children were infants aged of 0-12 months. The youngest age at TB diagnosis was 1 month and the lowest weight was 700 g. ANOVA regression for LBW and age at TB diagnosis, showed a multiple R value of 0.0256, p = 0.7659 (F = 0.7659, 95% CI). Conclusions: The correlation between clinical diagnosis of tuberculosis in children at various ages and their low birth weight was positive but was not statistically significant. However, this research hypothesis should be tested in further studies on larger population groups, due to the current public health context of "End TB", promoted worldwide.

Chromosome 10 Q26.1 Deletion Syndrome in a Patient Diagnosed Postnatal and the Mother Support for the Prevention of Postnatal Depression

“…This is the reason why mother must be educated not to use self-medication in pregnancy [30]. Also, mother must be educated about the risks of the low weight born children to develop in time also tuberculous infection [31]. There are also situations when the mother can suffer from a cancer so she needs a psycho-oncologic support because anxiety and depression can vary in a very wide range for these patients and sometimes malignancies are discovered just in the pregnancy controls, so the mother has a double exposure to stress factors, the birth itself and a new diagnosis of a disease (cancer, diabetes, varicella, aso.)…”

Tuberculosis and bacterial co-infections in children

“…Although TB is a preventable disease requiring coordinated systematic efforts, the prevalence is in fact the iceberg of the epidemiological burden and a child with active TB represents a sentinel event in the community, reflecting the intensive transmission among all the individuals. (2) Clinical symptoms of TB in children are often nonspecific, leading to a delayed diagnosis and a long period when the child is contagious and without specific treatment to prevent secondary transmission (9), and during this time the child, often immuno-suppressed, is exposed to the pressure of the circulating community pathogenic flora, often aggressive and with a high level of antibiotic resistance (10).…”

Fetomaternal Outcome of Pregnant Women Infected with Tuberculosis: An Analytical Study

“…Women with TB increase the risk of neonatal death by six times and double the risk of theirs being born prematurely or with low birth weight. 8 Several studies show that TB in pregnancy has been related to poor obstetrical, fetal, and perinatal outcome. But the early diagnosis of TB still remains the biggest obstacle in the management of the disease.…”