Risk of type 2 diabetes mellitus between adolescents with antidepressant-resistant and antidepressant-responsive depression: A cohort study of 15,651 adolescents

Hsu, Ju-Wei; Chen, Li-Chi; Huang, Kai‐Lin; Tsai, Shih‐Jen; Bai, Ya‐Mei; Su, Tung‐Ping; Chen, Tzeng Ji; Chen, Mu‐Hong

doi:10.1016/j.jad.2023.02.065

Cited by 2 publications

(1 citation statement)

References 24 publications

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“…The estimated prevalence of depression in T2DM patients is 25%, and it is associated with poorer blood glucose control in these patients ( 9 , 48 ). An analysis of data from the Taiwan National Health Insurance Research Database from 2001 to 2010 found that, compared to reactive depression patients responsive to antidepressants, patients with treatment-resistant depression were more likely to be diagnosed with T2DM in later life (HR 1.51) ( 49 ). Additionally, obesity, IR, and hypoglycemic abnormalities may result in relatively poor cognitive function in adolescents with both T2DM and obesity ( 50 ).…”

Section: Comprehensive and Accurate Understanding Of Yodm Is Key To D...mentioning

confidence: 99%

Reassessing type 2 diabetes in adolescents and its management strategies based on insulin resistance

Jia,

Zhang,

Zhang

et al. 2024

Front. Endocrinol.

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With changes in lifestyle behaviors, including dietary structure and habits, the prevalence of Youth-onset Type 2 Diabetes Mellitus (YODM) has increased 2 to 3 times compared to 30 years ago. YODM patients experience complications earlier, progress faster, and exhibit more severe symptoms. However, limited and inconclusive direct evidence, coupled with poor patient compliance, poses challenges in the clinical management of YODM. Apart from the continuous decline in pancreatic β-cell function and quantity, tissue-specific insulin resistance (IR) is also a typical characteristic of YODM. The main mechanisms of IR in YODM involve different aspects such as obesity, dietary imbalance, abnormal substance metabolism, chronic inflammation, oxidative stress, and hormonal fluctuations during adolescence. For the comprehensive management of YODM, besides achieving good control of blood glucose levels, it may be necessary to apply the most appropriate methods considering the uniqueness of the patient population and the specifics of the disease. Early identification and detection of the disease are crucial. Precise screening of patients with well-functioning pancreatic insulin β-cells, primarily characterized by IR and obesity, represents the population most likely to achieve diabetes remission or reversal through lifestyle modifications, medications, or even surgical interventions. Additionally, considering potential emotional disorders or the impact of adolescent hormones in these patients, health education for patients and caregivers is essential to make them aware of the long-term benefits of well-controlled blood glucose. In conclusion, adopting comprehensive management measures to achieve diabetes remission or reversal is the ideal goal. Controlling high blood glucose, obesity, and other risk factors related to diabetes complications is the next priority to delay the occurrence and progression of complications. A comprehensive perspective on IR provides insights and references for identifying YODM and its management strategies.

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Section: Comprehensive and Accurate Understanding Of Yodm Is Key To D...mentioning

confidence: 99%

Reassessing type 2 diabetes in adolescents and its management strategies based on insulin resistance

Jia,

Zhang,

Zhang

et al. 2024

Front. Endocrinol.

View full text Add to dashboard Cite

show abstract

Incident diabetes in adolescents using antidepressant: a systematic review and meta-analysis

Movahed,

Heidari,

Sadeghi

et al. 2024

Eur Child Adolesc Psychiatry

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Risk of type 2 diabetes mellitus between adolescents with antidepressant-resistant and antidepressant-responsive depression: A cohort study of 15,651 adolescents

Cited by 2 publications

References 24 publications

Reassessing type 2 diabetes in adolescents and its management strategies based on insulin resistance

Reassessing type 2 diabetes in adolescents and its management strategies based on insulin resistance

Incident diabetes in adolescents using antidepressant: a systematic review and meta-analysis

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