Risk of vestibulocochlear disorders in patients with migraine or non-migraine headache

Lee, Sang Hwa; Kim, Jong-Ho; Kwon, Yong-Soo; Lee, Jae-June; Sohn, Jong-Hee

doi:10.21203/rs.3.rs-958934/v1

Cited by 3 publications

(1 citation statement)

References 46 publications

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“…As mentioned above, migraine and MD have various phenotypes, often diagnosed by clinical features, showing some overlapped clinical symptoms, involving multiple etiologies and part of them can be related to several genes. Thus, more and more studies are linking migraine to recurrent vestibular problems (8,9). A recent population-based study in Korea found a bidirectional relationship between MD and migraine, sufferers with MD were more likely to get migraine, and migraine sufferers were more likely to develop MD (10).…”

Section: Introductionmentioning

confidence: 99%

Mendelian randomization analysis does not reveal a causal association between migraine and Meniere’s disease

Zhang,

et al. 2024

Front. Neurol.

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BackgroundAccording to observational research, migraine may increase the risk of Meniere’s disease (MD). The two have not, however, been proven to be causally related.MethodsUsing Mendelian random (MR) analysis, we aimed to evaluate any potential causal relationship between migraine and MD. We extracted single-nucleotide polymorphisms (SNPs) from large-scale genome-wide association studies (GWAS) involving European individuals, focusing on migraine and MD. The main technique used to evaluate effect estimates was inverse-variance weighting (IVW). To assess heterogeneity and pleiotropy, sensitivity analyses were carried out using weighted median, MR-Egger, simple mode, weighted mode, and MR-PRESSO.ResultsThere was no discernible causative link between genetic vulnerability to MD and migraine. The migraine dose not increase the prevalence of MD in the random-effects IVW method (OR = 0.551, P = 0.825). The extra weighted median analysis (OR = 0.674, P = 0.909), MR-Egger (OR = 0.068, P = 0.806), Simple mode (OR = 0.170, P = 0.737), and Weighted mode (OR = 0.219, P= 0.760) all showed largely consistent results. The MD dose not increase the prevalence of migraine in the random-effects IVW method (OR = 0.999, P = 0.020). The extra weighted median analysis (OR = 0.999, P = 0.909), MR-Egger (OR = 0.999, P = 0.806), Simple mode (OR = 0.999, P = 0.737), and Weighted mode (OR = 1.000, P = 0.760).Conclusion and significanceThis Mendelian randomization study provides casual evidence that migraine is not a risk factor for MD and MD is also not a risk factor for migraine.

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Section: Introductionmentioning

confidence: 99%

Mendelian randomization analysis does not reveal a causal association between migraine and Meniere’s disease

Zhang,

et al. 2024

Front. Neurol.

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Management of Migraine-Associated Vestibulocochlear Disorders

et al. 2023

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Migraine is a chronic neurological disorder that frequently coexists with different vestibular and cochlear symptoms (sudden hearing loss, tinnitus, otalgia, aural fullness, hyperacusis, dizziness, imbalance, and vertigo) and disorders (recurrent benign positional vertigo, persistent postural perceptual dizziness, mal de debarquement, and Menière’s disease). Despite evidence of an epidemiological association and similar pathophysiology between migraine and these vestibulocochlear disorders, patients suffering from migraine-related symptoms are usually underdiagnosed and undertreated. Current migraine treatment options have shown success in treating vestibulocochlear symptoms. Lifestyle and dietary modifications (reducing stress, restful sleep, avoiding migraine dietary triggers, and avoiding starvation and dehydration) and supplements (vitamin B2 and magnesium) offer effective first-line treatments. Treatment with migraine prophylactic medications such as tricyclic antidepressants (e.g., nortriptyline), anticonvulsants (e.g., topiramate), and calcium channel blockers (e.g., verapamil) is implemented when lifestyle and dietary modifications are not sufficient in improving a patient’s symptoms. We have included an algorithm that outlines a suggested approach for addressing these symptoms, taking into account our clinical observations. Greater recognition and understanding of migraine and its related vestibular and cochlear symptoms are needed to ensure the appropriate diagnosis and treatment of affected patients.

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Benign Paroxysmal Positional Vertigo Is Associated with an Increased Risk for Migraine Diagnosis: A Nationwide Population-Based Cohort Study

Shih

Hsu

et al. 2023

IJERPH

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Previous studies reported an increased risk of benign paroxysmal positional vertigo (BPPV) in patients with migraine. Hence, we aimed to assess the risk of migraine in patients with BPPV. This cohort study was conducted using the Taiwan National Health Insurance Research Database. The BPPV cohort consisted of patients aged <45 years with a diagnosis of BPPV between 2000 and 2009. An age- and sex-matched comparison group free from a history of BPPV or migraine was selected. All cases were followed up from 1 January 2000 to 31 December 2010 or until death or a diagnosis of migraine. The baseline demographic characteristics in both groups were compared using Student’s t-test and the chi-square test. Cox proportional hazards regression analysis was used to estimate the hazard ratio for migraine in the BPPV cohort compared with the comparison group after adjustment for age, sex, and comorbidities. Notably, 117 of the 1386 participants with BPPV and 146 of the 5544 participants without BPPV developed migraine. After adjustment for age, sex, and comorbidities, BPPV showed an adjusted hazard ratio indicating a 2.96-fold increased risk of migraine (95% confidence interval: 2.30–3.80, p < 0.001). We found that BPPV is associated with an increased risk of a migraine diagnosis.

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Risk of vestibulocochlear disorders in patients with migraine or non-migraine headache

Cited by 3 publications

References 46 publications

Mendelian randomization analysis does not reveal a causal association between migraine and Meniere’s disease

Mendelian randomization analysis does not reveal a causal association between migraine and Meniere’s disease

Management of Migraine-Associated Vestibulocochlear Disorders

Benign Paroxysmal Positional Vertigo Is Associated with an Increased Risk for Migraine Diagnosis: A Nationwide Population-Based Cohort Study

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